Effect of Maternal Anemia on Birth Weight among Newborns
DOI:
https://doi.org/10.51985/Keywords:
Anemia, low birth weight, pregnancyAbstract
Objectives: To evaluate the association between maternal anemia and low birth weight in newborn at SITH, Lodhran. Study design & settings: Prospective cohort study at Department of Pediatrics nursery and gynae and obs department at Shahida Islam Teaching Hospital, Lodhran.
Materials & Methods: Pregnant women of child bearing age between 18 and 40 years with singleton pregnancies confirmed via ultrasound were included. Those who were pregnant with hemoglobinopathies, multiple pregnancies (twins, triplets, etc.), preterm pregnancy, pregnant and had such conditions as GDM, PIH, preeclampsia were excluded. Two groups of women will be divided as having been exposed and not being so. Exposed group (Anemic mothers): Hemoglobin level of less than 11 g/dL in pregnant women, as tested during their third trimester. Unexposed group (non-anemic mothers): Hemoglobin level of =11 g/dL in pregnant women, as assessed during their third trimester. The weight of babies at the time of birth was determined within 30 minutes of birth using a standard calibrated digital weighing scale, and noted in grams.
Results: Low weight of babies at birth was observed in 24(48.0%) women and was anaemic as compared to 08 (16.0%) women who were non-anaemic thus the p-value of 0.002 and relative risk of 3.00 which is noticeable and represents positive relationship of maternal anemia and low weight of babies in our study.
Conclusion: Following findings carried in the study, the likelihood of anemic women bearing low birth weight babies is greater than non-anemic women.
References
1. Kabir MA, Rahman MM, Khan MN. Maternal anemia and
risk of adverse maternal health and birth outcomes in
Bangladesh: A nationwide population-based survey. PLoS
One. 2022 Dec 16;17(12):e0277654. doi: 10.1371/journal.pone.
0277654. PMID: 36525409; PMCID: PMC9757595.
2. Singh S, Rathoria E, Srivastava M, Rathoria R, Bansal U,
Sharma K. Impact of maternal anemia on neonatal outcomes.
Int J Contemp Pediatr 2024;11:1781-7.
3. Shi H, Chen L, Wang Y, Sun M, Guo Y, Ma S, et al. Severity
of anemia during pregnancy and adverse maternal and fetal
outcomes. JAMA Netw Open. 2022 Feb 1;5(2):e2147046.
doi: 10.1001/jamanetworkopen.2021.47046. PMID: 35113162;
PMCID: PMC8814908.
4. Figueiredo A, Gomes-Filho I, Batista J, Orrico G, Porto E,
Pimenta R, et al. Maternal anemia and birth weight: A
prospective cohort study. PLoS ONE 2019;14. https://doi.org
/10.1371/journal.pone.0212817.
5. Sun CF, Liu H, Hao YH. Association between gestational
anemia in different trimesters and neonatal outcomes: a
retrospective longitudinal cohort study. World J Pediatr
2021;17:197–204. https://doi.org/10.1007/s12519-021-00411-
6
6. Shah T, Warsi J, Laghari Z. Effect of Maternal Anemia on
the Anthropometric Indices of Newborn. J Liaquat Uni Med
Health Sci. 2020;19:191-4.
7. Verma J, Jain S, Anand S. Maternal anemia – an important
determinant of low birth weight babies – An observational
study from central India. IP Int J Med Paediatr Oncol. 2018;4(2)
:67-70. https://doi.org/10.18231/2581-4702.2018.0014.
8. Rauf S, Mandokhel S, Pirzada H, Sher R, Shakeel M. Factors
associated with maternal anemia and its relationship with a
low birth weight of newborn. Pak J Med Health Sci.
2022;16(11):304-6. https://doi. org/10.53350/ pjmhs20221
6113049. Engidaw MT, Eyayu T, Tiruneh T. The effect of maternal
anaemia on low birth weight among newborns in Northwest
Ethiopia. Sci Rep. 2022 Sep 10;12(1):15280. doi: 10.1038/
s41598-022-19726-z. PMID: 36088384; PMCID: PMC9
464186.
10. Singh R, Chauhan R, Nandan D, Singh H. A study on anemia
among pregnant women in rural area of India. Indian J Public
Health. 2014;58(1):51–6.
11. Kumar KJ, Asha N, Murthy DS. Prevalence of anemia and
its association with birth outcomes among pregnant women
in a rural community of Karnataka. Int J Community Med
Public Health. 2018;5(4):1410–13.
12. Kassa GM, Muche AA, Berhe AK, Fekadu GA. Prevalence
and determinants of anemia among pregnant women in
Ethiopia: a systematic review and meta-analysis. BMC
Hematol. 2017;17:17.
13. Figueiredo ACMG, Gomes-Filho IS, Silva RB, et al. Maternal
anemia and low birth weight: a systematic review and meta
analysis. Nutrients. 2018;10(5):601.
14. Rahmati S, Delpisheh A, Azami M, Hafezi Ahmadi MR,
Sayehmiri K. Maternal anemia and pregnancy outcomes: a
systematic review and meta-analysis. BMC Pregnancy
Childbirth. 2022;22:13.
15. Kemppinen L. Gestational iron deficiency anemia is associated
with preterm birth, fetal growth restriction, and postpartum
infections. J Perinat Med. 2021;49(4):431–8.
16. Khezri R, Salarilak S, Jahanian S. The association between
maternal anemia during pregnancy and preterm birth. Clin
Nutr Espen. 2023;56:13–7.
17. Biswas P, Samsuzzaman M, Chakraborty A, Das DK. Maternal
anemia and low birth weight in a community development
block of purba Bardhaman, West Bengal: a retrospective
cohort analysis. J. Maternal and Child Health. 2019.
18. Wahyuni S, Putri ARA, Imbir S. The Relationship of anemia
in pregnancy with the event of lbw babies (low birth weight)
at Supiori Hospital. J Kebidanan Kestra (Jkk). 2022;4(2):108
–12.
19. Tessema ZT, Tamirat KS, Teshale AB, Tesema GA. Prevalence
of low birth weight and its associated factor at birth in SubSaharan Africa: A generalized linear mixed model. PloS one.
2021 Mar;16(3): e0248417.
20. Puerto A, Trojan A, Alvis-Zakzuk NR, López-Saleme R,
Edna-Estrada F, Alvarez A et al. Iron status in late pregnancy
is inversely associated with birth weight in Colombia. Public
Health Nutrition. 2021Oct;24(15): 5090-100.
21. Seid S, Wondafrash B, Gali N, Ali A, Mohammed B, Kedir
S. Determinants of low Birth Weight among newborns
delivered in Silte Zone Public Health Facilities, Southern
Ethiopia: a case-control study. Res Reports Neonatol. 2022:19-
29.doi: 10.2147/RRN.S368436.
22. Iltaf G, Shahid B, Khan MI. Incidence and associated risk
factors of low birth weight babies born in Shaikh Khalifa Bin
Zayad Al-Nayan Hospital Muzaffarabad, Azad Jammu and
Kashmir.Pakistan J Med Sci. 2017;33(3): 626.doi:10.
12669/pjms.333 .12413.23. Chiai M, Kurata H, Inoue H, Tanaka K, Matsushita Y, Fujiyoshi
J et al. An elevation of serum ferritin level might increase
clinical risk for the persistence of patent ductus arteriosus,sepsis
and bronchopulmonary dysplasia in erythropoietin treated
very-Low Birth Weight infants. Neonatol. 2016;111(1):68-
75. doi: 10.1159/000447991.
24. Devaguru A, Gada S, Potpalle D, Eshwar MD, Purwar D.
The prevalence of low birth weight among newborn babies
and its associated maternal risk factors: a hospital-based crosssectional study. Cureus. 2023;15(5). doi: 10.7759/cureus.38587.
25. Arsyi M, Besral B, Herdayati M, Phalkey R. Antenatal care
services and incidence of low birth weight: a comparison of
demographic and health surveys in 4 ASEAN countries. J
Preventive Med Public Health. 2022;55(6):559.doi: 10.3961
/jpmph .22.316.
26. Ataide R, Fielding K, Pasricha SR, Bennett C. Iron de ciency,
pregnancy, and neonatal development. International Journal
of Gynecology & Obstetrics. 2023;162:14-22. doi: 10.1002/
go.14944.
27. Fite MB, Tura AK, Yadeta TA, Oljira L, Roba KT. Prevalence,
predictors of low birth weight and its association with maternal
iron status using serum ferritin concentration in rural Eastern
Ethiopia: a prospective cohort study. BioMed Central Nutrition.
2022 Jul; 8(1): 70. doi: 10.1186/s40795-022-00561-4.
28. Asinobi IN. Serum Ferritin - The Role of Birthweight: A
Comparative Study. Asian Journal of Pediatric Research. 2023
May [cited: 12th Mar 2025]. Available at:https://journalajpr.
com/index.php/AJPR/article/vi ew/249. doi: 10.9734/
ajpr/2023/v13i1249.
29. Liu D, Li S, Zhang B, Kang Y, Cheng Y, Zeng L et al. Maternal
hemoglobin concentrations and birth weight, low birth weight
(LBW), and small for gestational age (SGA): ndings from a
prospective study in Northwest China. Nutrients. 2022;14(4):
858. doi: 10.3390/nu1404085.
30. Kishwar N, Bakhtiar U, Ali S, Karim R, Tabassum S, Mudassir
S. Frequency of low birth weight in babies born to anemic
pregnant women at term gestation; a cross-sectional study. J
Gandhara Med Dental Sci. 2024;11(3):21-4. doi: 10.37 762/
jgmds.11-3.587.
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