Estimation of the Aortic Valve Annular Size Measured by Pre-Operative Echocardiogram Validated Against Intra Operative Measurement by Standard Valve Sizers in Patient Undergoing Aortic Valve Replacement Open Heart Surgery

Authors

  • Muhammad Aftab Alam Khan Author
  • Muhammad Aasim Author
  • Ata Ul Mohsin Author
  • Sajid Khan Author
  • Muhammad Sadeeq Author
  • Abdul Aziz Ahmad Author

DOI:

https://doi.org/10.51985/

Keywords:

Aortic Valve, Aortic Valve Stenosis, Diagnostic Accuracy, Echocardiography, Heart Valve Prosthesis Implantation, Intraoperative Care

Abstract

 Objective: This study was carried out to determine the diagnostic accuracy of transthoracic echocardiography (TTE) for preoperative sizing of the aortic annulus. It was done by comparing its measurements against the reference standard of direct intraoperative valve sizer measurement in patients who were undergoing surgical aortic valve replacement (SAVR).

 

Methodology: This cross-sectional was conducted at the Department of Cardiac Surgery, Hayatabad Medical Complex, Peshawar. from January 2023 to June 2023. Total 194 consecutive patients who were scheduled for SAVR were enrolled. Preoperative TTE measurements of the aortic annulus were performed in the parasternal long-axis view. The primary outcome was the agreement between TTE and sizer measurements. For this the concordance was defined as a difference of ±1 mm. After data collection the statistical analysis was performed using SPSS version 20.

 

Results: The mean age of our study population was found to be 66.8 ± 10.5 years, with 63.4% males. The TTE and sizer measurement showed a very strong positive correlation (r = 0.978, p<0.001). However, TTE systematically underestimated the annular diameter with a mean bias of -1.41 mm. The range of Bland-Altman limits of agreement was from -2.31 mm to -0.50 mm. The clinical concordance rate within ±1 mm was 81.4%. while analyzing the subgroups based on gender or valve morphology, they showed no significant differences in measurement discrepancy (p>0.05).

 

Conclusion: The TTE establishes a very strong correlation with direct intraoperative sizing, but it also exhibits a consistent underestimation bias 

References

1. Santangelo G, Bursi F, Faggiano A, Moscardelli S, Simeoli

PS, Guazzi M, Lorusso R, Carugo S, Faggiano P. The global

burden of valvular heart disease: from clinical epidemiology

to management. Journal of clinical medicine. 2023 Mar

10;12(6):2178. https://doi.org/10.3390/jcm12062178

2. Scully PR, Patel KP, Treibel TA, Thornton GD, Hughes RK,

Chadalavada S, Katsoulis M, Hartman N, Fontana M, Pugliese

F, Sabharwal N. Prevalence and outcome of dual aortic

stenosis and cardiac amyloid pathology in patients referred

for transcatheter aortic valve implantation. European heart

journal. 2020 Aug 1;41(29):2759-67. https://doi.org/10.1093/

eurheartj/ehaa170

3. Bhatti S, Rehman S, Usman M, Iqbal Z, Atif U, Gurmani S,

Hussain W, Memon R, Awan AB, Mangi AJ, Karim M.

Valvular heart disease care in Pakistan: impact of the

multidisciplinary valve heart team. JACC: Advances. 2024

Dec 1;3(12_Part_2):1013784. Piazza N. Anatomy and Imaging of the Aortic Valvar Complex

for Transcatheter Aortic Valve Implantation. InTranscatheter

Aortic Valve Implantation 2024 Sep 10 (pp. 11-27). CRC

Press.

5. Giuliani C, Zanuttini A, Hecht S, Ternacle J, Pibarot P.

Prosthesis-Patient Mismatch: Current State of Evidence.

Current Cardiology Reports. 2025 Dec;27(1):49. https://doi.org/

10.1007/s11886-025-02212-z

6. Rana M. Aortic valve stenosis: diagnostic approaches and

recommendations of the 2021 ESC/EACTS guidelines for

the management of valvular heart disease–a review of the

literature. Cardiology and cardiovascular medicine. 2022 Jun

27;6(3):315. doi:10.26502/fccm.92920267

7. Frazao C, Tavoosi A, Wintersperger BJ, Nguyen ET, Wald

RM, Ouzounian M, Hanneman K. Multimodality assessment

of thoracic aortic dimensions: comparison of computed

tomography angiography, magnetic resonance imaging, and

echocardiography measurements. Journal of Thoracic Imaging.

2020 Nov 1;35(6):399-406. DOI: 10.1097/RTI. 000000000

0000514

8. Fortuni F, Delgado V. Assessment of aortic valve stenosis

severity: multimodality imaging may be the key. European

Heart Journal-Cardiovascular Imaging. 2020 Oct;21(10):1103-

4. https://doi.org/10.1093/ehjci/jeaa129

9. Choe J, Koo HJ, Kang JW, Kim JB, Kang HJ, Yang DH.

Aortic annulus sizing in bicuspid and tricuspid aortic valves

using CT in patients with surgical aortic valve replacement.

Scientific Reports. 2021 Oct 25;11(1):21005. https://doi.org/

10.1038/s41598-021-00406-3

10. Huckaby LV, Fortunato RN, Emerel LV, Phillippi JA, Billaud

M, Vorp DA, Maiti S, Gleason TG. Wall Tensile Stress Maps

of Human Aneurysmal Aorta Demonstrate a High Biaxiality

Ratio Corresponds with Wall Tissue Microstructure and Local

Oxidative Stress Response Distinctly for Bicuspid and

Tricuspid Aortic Valve Patients: LV Huckaby et al. Annals of

Biomedical Engineering. 2025 Jun 17:1-6. https://doi10.1007/

s10439-025-03771

11. Vaidya YP, Cavanaugh SM, Sandhu AA. Surgical aortic valve

replacement in small aortic annulus. Journal of Cardiac

Surgery. 2021 Jul;36(7):2502-9. https://doi10.1111/jocs.15555.

12. Navarro SM, Shaikh H, Abdi H, Keil EJ, Odusanya S, Stewart

KA, Tuyishime E, Mazingi D, Tuttle TM. Surgical applications

of ultrasound use in low-and middle-income countries: a

systematic review. Australasian Journal of Ultrasound in

Medicine. 2022 May;25(2):80-97. https://doi10.1002/ajum.

12302.

13. Akhtar H, Tareen I, Hussain SM, Zia K, Sohail OB, Khan

MI. Accuracy of TTE in Aortic Annulus Sizing: Comparison

with Intraoperative Measurements. Pakistan Heart Journal.

2025 Jun 30;58(2):225-9. https://doi.org/10.47144/

phj.v58i2.2738

14. Björn R, Nissinen M, Lehto J, Malmberg M, Yannopoulos F,

Airaksinen KJ, Hartikainen JE, Nieminen T, Biancari F, Gunn

J, Kiviniemi TO. Late incidence and recurrence of new-onset

atrial fibrillation after isolated surgical aortic valve replacement.

The Journal of Thoracic and Cardiovascular Surgery. 2022

Dec 1;164(6):1833-43. https://doi.org/10.1016/j.

jtcvs.2021.03.101

15. Buderer NM. Statistical methodology: I. Incorporating the

prevalence of disease into the sample size calculation for

sensitivity and specificity. Academic Emergency Medicine.

1996 Sep;3(9):895-900.

16. Wang H, Hanna JM, Ganapathi A, Keenan JE, Hurwitz LM,

Vavalle JP, Kiefer TL, Wang A, Harrison JK, Hughes GC.

Comparison of aortic annulus size by transesophageal

echocardiography and computed tomography angiography

with direct surgical measurement. The American journal of

cardiology. 2015 Jun 1;115(11):1568-73.

17. Altman DG, Bland JM. Diagnostic tests. 1: Sensitivity and

specificity. BMJ: British Medical Journal. 1994 Jun

11;308(6943):1552. doi: 10.1136/bmj.308.6943.1552

18. Bland JM, Altman D. Statistical methods for assessing

agreement between two methods of clinical measurement.

The lancet. 1986 Feb 8;327(8476):307-10. https://doi.org

/10.1016/ S0140-6736(86)90837-8

19. Kasel AM, Cassese S, Bleiziffer S, Amaki M, Hahn RT,

Kastrati A, Sengupta PP. Standardized imaging for aortic

annular sizing: implications for transcatheter valve selection.

JACC: Cardiovascular Imaging. 2013 Feb;6(2):249-62.

https://doi.org/10.1016/j.jcmg.2012.12.005

20. Piazza N, de Jaegere P, Schultz C, Becker AE, Serruys PW,

Anderson RH. Anatomy of the aortic valvar complex and its

implications for transcatheter implantation of the aortic valve.

Circulation: Cardiovascular Interventions. 2008 Aug;1(1):74-

81. https://doi.org/10.1161/CIRCINTERVENTIONS.

108.780858

21. Altiok E, Koos R, Schröder J, Brehmer K, Hamada S, Becker

M, Mahnken AH, Almalla M, Dohmen G, Autschbach R,

Marx N. Comparison of two-dimensional and threedimensional imaging techniques for measurement of aortic

annulus diameters before transcatheter aortic valve

implantation. Heart. 2011 Oct 1;97(19):1578-84. https://doi.

org/10.1136/hrt.2011.223974

22. George I, Guglielmetti LC, Bettinger N, Moss A, Wang C,

Kheysin N, Hahn R, Kodali S, Leon M, Bapat V, Borger MA.

Aortic valve annular sizing: intraoperative assessment versus

preoperative multidetector computed tomography. Circulation:

Cardiovascular Imaging. 2017 May;10(5):e005968.

https://doi.org/10.1161/CIRCIMAGING.116.005968

23. Faletti R, Gatti M, Cosentino A, Bergamasco L, Stura EC,

Garabello D, Pennisi G, Salizzoni S, Veglia S, Ottavio D,

Rinaldi M. 3D printing of the aortic annulus based on

cardiovascular computed tomography: preliminary experience

in pre-procedural planning for aortic valve sizing. Journal of

cardiovascular computed tomography. 2018 Sep 1;12(5):391-

7. https://doi.org/10.1016/j.jcct.2018.05.016

24. Jilaihawi H, Kashif M, Fontana G, Furugen A, Shiota T, Friede

G, Makhija R, Doctor N, Leon MB, Makkar RR. Crosssectional computed tomographic assessment improves accuracy

of aortic annular sizing for transcatheter aortic valve

replacement and reduces the incidence of paravalvular aortic

regurgitation. Journal of the American College of Cardiology.

2012 Apr 3;59(14):1275-86. https://doi.org/10.1016/j.

jacc.2011.11.045

25. Subramaniam K, Boisen ML, Yehushua L, Esper SA, Philips

DP, Howard-Quijano K. Perioperative transthoracic

echocardiography practice by cardiac anesthesiologists—

report of a “start-up” experience. Journal of Cardiothoracic

and Vascular Anesthesia. 2021 Jan 1;35(1):222-32.

https://doi.org/10.1053/j.jvca.2020.06.046

26. Venkatram P. Parasternal Short Axis (PSAX) View.(Left

Parasternal Window). InHeart diseases and echocardiogram:

Principles in practice 2024 Aug 10 (pp. 549-568). Cham:

Springer Nature Switzerland. https://doi.org/10.1007/978-3-

031-59246-1_40

27. Çekmecelioðlu D, Kibler K, Orozco-Sevilla V, Coselli JS.

Cardiopulmonary bypass in thoracic aortic surgery.

InCardiopulmonary Bypass 2023 Jan 1 (pp. 395-419).

Academic Press. https://DOI.10.1016/B978-0-443-18918-

0.00024-3

Downloads

Published

2026-04-21

Issue

Section

Original Articles

How to Cite

Estimation of the Aortic Valve Annular Size Measured by Pre-Operative Echocardiogram Validated Against Intra Operative Measurement by Standard Valve Sizers in Patient Undergoing Aortic Valve Replacement Open Heart Surgery. (2026). Journal of Bahria University Medical and Dental College, 16(02), 627-633. https://doi.org/10.51985/

Similar Articles

21-30 of 58

You may also start an advanced similarity search for this article.