Estimation of the Aortic Valve Annular Size Measured by Pre-Operative Echocardiogram Validated Against Intra Operative Measurement by Standard Valve Sizers in Patient Undergoing Aortic Valve Replacement Open Heart Surgery
DOI:
https://doi.org/10.51985/Keywords:
Aortic Valve, Aortic Valve Stenosis, Diagnostic Accuracy, Echocardiography, Heart Valve Prosthesis Implantation, Intraoperative CareAbstract
Objective: This study was carried out to determine the diagnostic accuracy of transthoracic echocardiography (TTE) for preoperative sizing of the aortic annulus. It was done by comparing its measurements against the reference standard of direct intraoperative valve sizer measurement in patients who were undergoing surgical aortic valve replacement (SAVR).
Methodology: This cross-sectional was conducted at the Department of Cardiac Surgery, Hayatabad Medical Complex, Peshawar. from January 2023 to June 2023. Total 194 consecutive patients who were scheduled for SAVR were enrolled. Preoperative TTE measurements of the aortic annulus were performed in the parasternal long-axis view. The primary outcome was the agreement between TTE and sizer measurements. For this the concordance was defined as a difference of ±1 mm. After data collection the statistical analysis was performed using SPSS version 20.
Results: The mean age of our study population was found to be 66.8 ± 10.5 years, with 63.4% males. The TTE and sizer measurement showed a very strong positive correlation (r = 0.978, p<0.001). However, TTE systematically underestimated the annular diameter with a mean bias of -1.41 mm. The range of Bland-Altman limits of agreement was from -2.31 mm to -0.50 mm. The clinical concordance rate within ±1 mm was 81.4%. while analyzing the subgroups based on gender or valve morphology, they showed no significant differences in measurement discrepancy (p>0.05).
Conclusion: The TTE establishes a very strong correlation with direct intraoperative sizing, but it also exhibits a consistent underestimation bias
References
1. Santangelo G, Bursi F, Faggiano A, Moscardelli S, Simeoli
PS, Guazzi M, Lorusso R, Carugo S, Faggiano P. The global
burden of valvular heart disease: from clinical epidemiology
to management. Journal of clinical medicine. 2023 Mar
10;12(6):2178. https://doi.org/10.3390/jcm12062178
2. Scully PR, Patel KP, Treibel TA, Thornton GD, Hughes RK,
Chadalavada S, Katsoulis M, Hartman N, Fontana M, Pugliese
F, Sabharwal N. Prevalence and outcome of dual aortic
stenosis and cardiac amyloid pathology in patients referred
for transcatheter aortic valve implantation. European heart
journal. 2020 Aug 1;41(29):2759-67. https://doi.org/10.1093/
eurheartj/ehaa170
3. Bhatti S, Rehman S, Usman M, Iqbal Z, Atif U, Gurmani S,
Hussain W, Memon R, Awan AB, Mangi AJ, Karim M.
Valvular heart disease care in Pakistan: impact of the
multidisciplinary valve heart team. JACC: Advances. 2024
Dec 1;3(12_Part_2):1013784. Piazza N. Anatomy and Imaging of the Aortic Valvar Complex
for Transcatheter Aortic Valve Implantation. InTranscatheter
Aortic Valve Implantation 2024 Sep 10 (pp. 11-27). CRC
Press.
5. Giuliani C, Zanuttini A, Hecht S, Ternacle J, Pibarot P.
Prosthesis-Patient Mismatch: Current State of Evidence.
Current Cardiology Reports. 2025 Dec;27(1):49. https://doi.org/
10.1007/s11886-025-02212-z
6. Rana M. Aortic valve stenosis: diagnostic approaches and
recommendations of the 2021 ESC/EACTS guidelines for
the management of valvular heart disease–a review of the
literature. Cardiology and cardiovascular medicine. 2022 Jun
27;6(3):315. doi:10.26502/fccm.92920267
7. Frazao C, Tavoosi A, Wintersperger BJ, Nguyen ET, Wald
RM, Ouzounian M, Hanneman K. Multimodality assessment
of thoracic aortic dimensions: comparison of computed
tomography angiography, magnetic resonance imaging, and
echocardiography measurements. Journal of Thoracic Imaging.
2020 Nov 1;35(6):399-406. DOI: 10.1097/RTI. 000000000
0000514
8. Fortuni F, Delgado V. Assessment of aortic valve stenosis
severity: multimodality imaging may be the key. European
Heart Journal-Cardiovascular Imaging. 2020 Oct;21(10):1103-
4. https://doi.org/10.1093/ehjci/jeaa129
9. Choe J, Koo HJ, Kang JW, Kim JB, Kang HJ, Yang DH.
Aortic annulus sizing in bicuspid and tricuspid aortic valves
using CT in patients with surgical aortic valve replacement.
Scientific Reports. 2021 Oct 25;11(1):21005. https://doi.org/
10.1038/s41598-021-00406-3
10. Huckaby LV, Fortunato RN, Emerel LV, Phillippi JA, Billaud
M, Vorp DA, Maiti S, Gleason TG. Wall Tensile Stress Maps
of Human Aneurysmal Aorta Demonstrate a High Biaxiality
Ratio Corresponds with Wall Tissue Microstructure and Local
Oxidative Stress Response Distinctly for Bicuspid and
Tricuspid Aortic Valve Patients: LV Huckaby et al. Annals of
Biomedical Engineering. 2025 Jun 17:1-6. https://doi10.1007/
s10439-025-03771
11. Vaidya YP, Cavanaugh SM, Sandhu AA. Surgical aortic valve
replacement in small aortic annulus. Journal of Cardiac
Surgery. 2021 Jul;36(7):2502-9. https://doi10.1111/jocs.15555.
12. Navarro SM, Shaikh H, Abdi H, Keil EJ, Odusanya S, Stewart
KA, Tuyishime E, Mazingi D, Tuttle TM. Surgical applications
of ultrasound use in low-and middle-income countries: a
systematic review. Australasian Journal of Ultrasound in
Medicine. 2022 May;25(2):80-97. https://doi10.1002/ajum.
12302.
13. Akhtar H, Tareen I, Hussain SM, Zia K, Sohail OB, Khan
MI. Accuracy of TTE in Aortic Annulus Sizing: Comparison
with Intraoperative Measurements. Pakistan Heart Journal.
2025 Jun 30;58(2):225-9. https://doi.org/10.47144/
phj.v58i2.2738
14. Björn R, Nissinen M, Lehto J, Malmberg M, Yannopoulos F,
Airaksinen KJ, Hartikainen JE, Nieminen T, Biancari F, Gunn
J, Kiviniemi TO. Late incidence and recurrence of new-onset
atrial fibrillation after isolated surgical aortic valve replacement.
The Journal of Thoracic and Cardiovascular Surgery. 2022
Dec 1;164(6):1833-43. https://doi.org/10.1016/j.
jtcvs.2021.03.101
15. Buderer NM. Statistical methodology: I. Incorporating the
prevalence of disease into the sample size calculation for
sensitivity and specificity. Academic Emergency Medicine.
1996 Sep;3(9):895-900.
16. Wang H, Hanna JM, Ganapathi A, Keenan JE, Hurwitz LM,
Vavalle JP, Kiefer TL, Wang A, Harrison JK, Hughes GC.
Comparison of aortic annulus size by transesophageal
echocardiography and computed tomography angiography
with direct surgical measurement. The American journal of
cardiology. 2015 Jun 1;115(11):1568-73.
17. Altman DG, Bland JM. Diagnostic tests. 1: Sensitivity and
specificity. BMJ: British Medical Journal. 1994 Jun
11;308(6943):1552. doi: 10.1136/bmj.308.6943.1552
18. Bland JM, Altman D. Statistical methods for assessing
agreement between two methods of clinical measurement.
The lancet. 1986 Feb 8;327(8476):307-10. https://doi.org
/10.1016/ S0140-6736(86)90837-8
19. Kasel AM, Cassese S, Bleiziffer S, Amaki M, Hahn RT,
Kastrati A, Sengupta PP. Standardized imaging for aortic
annular sizing: implications for transcatheter valve selection.
JACC: Cardiovascular Imaging. 2013 Feb;6(2):249-62.
https://doi.org/10.1016/j.jcmg.2012.12.005
20. Piazza N, de Jaegere P, Schultz C, Becker AE, Serruys PW,
Anderson RH. Anatomy of the aortic valvar complex and its
implications for transcatheter implantation of the aortic valve.
Circulation: Cardiovascular Interventions. 2008 Aug;1(1):74-
81. https://doi.org/10.1161/CIRCINTERVENTIONS.
108.780858
21. Altiok E, Koos R, Schröder J, Brehmer K, Hamada S, Becker
M, Mahnken AH, Almalla M, Dohmen G, Autschbach R,
Marx N. Comparison of two-dimensional and threedimensional imaging techniques for measurement of aortic
annulus diameters before transcatheter aortic valve
implantation. Heart. 2011 Oct 1;97(19):1578-84. https://doi.
org/10.1136/hrt.2011.223974
22. George I, Guglielmetti LC, Bettinger N, Moss A, Wang C,
Kheysin N, Hahn R, Kodali S, Leon M, Bapat V, Borger MA.
Aortic valve annular sizing: intraoperative assessment versus
preoperative multidetector computed tomography. Circulation:
Cardiovascular Imaging. 2017 May;10(5):e005968.
https://doi.org/10.1161/CIRCIMAGING.116.005968
23. Faletti R, Gatti M, Cosentino A, Bergamasco L, Stura EC,
Garabello D, Pennisi G, Salizzoni S, Veglia S, Ottavio D,
Rinaldi M. 3D printing of the aortic annulus based on
cardiovascular computed tomography: preliminary experience
in pre-procedural planning for aortic valve sizing. Journal of
cardiovascular computed tomography. 2018 Sep 1;12(5):391-
7. https://doi.org/10.1016/j.jcct.2018.05.016
24. Jilaihawi H, Kashif M, Fontana G, Furugen A, Shiota T, Friede
G, Makhija R, Doctor N, Leon MB, Makkar RR. Crosssectional computed tomographic assessment improves accuracy
of aortic annular sizing for transcatheter aortic valve
replacement and reduces the incidence of paravalvular aortic
regurgitation. Journal of the American College of Cardiology.
2012 Apr 3;59(14):1275-86. https://doi.org/10.1016/j.
jacc.2011.11.045
25. Subramaniam K, Boisen ML, Yehushua L, Esper SA, Philips
DP, Howard-Quijano K. Perioperative transthoracic
echocardiography practice by cardiac anesthesiologists—
report of a “start-up” experience. Journal of Cardiothoracic
and Vascular Anesthesia. 2021 Jan 1;35(1):222-32.
https://doi.org/10.1053/j.jvca.2020.06.046
26. Venkatram P. Parasternal Short Axis (PSAX) View.(Left
Parasternal Window). InHeart diseases and echocardiogram:
Principles in practice 2024 Aug 10 (pp. 549-568). Cham:
Springer Nature Switzerland. https://doi.org/10.1007/978-3-
031-59246-1_40
27. Çekmecelioðlu D, Kibler K, Orozco-Sevilla V, Coselli JS.
Cardiopulmonary bypass in thoracic aortic surgery.
InCardiopulmonary Bypass 2023 Jan 1 (pp. 395-419).
Academic Press. https://DOI.10.1016/B978-0-443-18918-
0.00024-3
Downloads
Published
Issue
Section
License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Journal of Bahria University Medical & Dental College is an open access journal and is licensed under CC BY-NC 4.0. which permits unrestricted non commercial use, distribution and reproduction in any medium, provided the original work is properly cited. To view a copy of this license, visit https://creativecommons.org/licenses/by-nc/4.0