Clinical Outcomes of Magnesium Sulphate Nebulization in Acute Bronchiolitis Patients Admitted in a Tertiary Care Hospital
DOI:
https://doi.org/10.51985/Keywords:
Bronchiolitis, Children, Magnesium Sulphate, Nebulization.Abstract
Objective: The objective of this research is to analyze the treatment results of nebulized magnesium sulphate for acute bronchiolitis patients requiring hospital admission at a tertiary care medical facility.
Study design and Setting: After the ethical approval from the institutional review board of PNS Shifa, this prospective observational study was conducted at PNS Shifa hospital, Karachi, from December 2024 to May 2025.
Methodology: This prospective observational study was conducted at PNS Shifa Hospital, Karachi (Dec 2024–May 2025; ERC/2023/Paeds/25-A). One hundred children (1–24 months) with acute bronchiolitis were enrolled; exclusions were congenital heart or lung disease, immunodeficiency, bacterial pneumonia, or prior intubation. Patients received either standard supportive care or standard care plus nebulized magnesium sulphate (150 mg in 2 mL NS every 6 hours for 24–48 h). Respiratory parameters, ICU admission, ventilator need, and hospital stay were assessed. Data were analyzed in SPSS v25 using paired t-test/chi-square with significance at p<0.05.
Results: A total of 100 children were enrolled (33 standard nebulization, 67 magnesium sulphate). Baseline demographics, weight, respiratory rate, and oxygen saturation were comparable between groups (p>0.05). Post-treatment oxygen saturation improved significantly with magnesium sulphate (97.2% vs. 95.8%, p=0.003), while respiratory rate reduction was similar (p=0.666). ICU admissions were lower with magnesium sulphate (15% vs. 30%, p=0.017). Length of stay, number of nebulization, need for ventilation, and mortality showed no significant differences.
Conclusions: Nebulized magnesium sulphate in addition to standard care significantly improved oxygen saturation and reduced ICU admissions in children with acute bronchiolitis.
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