Association of Hypocalcemia and Elevated Parathyroid Hormone with Delayed Tooth Eruption in Children. A Cross-Sectional Study from a Pediatric and Dental Cohort
DOI:
https://doi.org/10.51985/JBUMDC2025663Keywords:
Dentine Score, Hypocalcemia, Parathyroid Hormone, Tooth EruptionAbstract
Objectives: This study aimed to evaluate the association between biochemical parameters and stunted odontogenesis in
children attending dental and pediatric clinics.
Study design and setting: This cross-sectional study was conducted at the dental OPD of LUMHS, Jamshoro, Sindh.
Methodology: After approval from the research ethics committee (DREC/113, dated 17/06/24), this study was conducted
among 250 children aged 2–16 years, from 1st July 2024 to 31 December 2024. Clinical assessment included dentine
scoring and evaluation of delayed tooth eruption. Biochemical analysis measured serum calcium, PTH, vitamin D, magnesium,
sodium, potassium, iron, folic acid, calcitonin, urea, and creatinine. Comparative analysis, ANOVA, and regression were
performed using SPSS, with significance set at p < 0.05.
Results: Delayed tooth eruption was observed in 88.4% of participants. Mean serum calcium was below normal (7.98 ±
1.10 mg/dL), with elevated mean PTH (18.90 ± 22.78 pg/mL). Children with delayed eruption had lower calcium levels
(p = 0.001) and higher PTH levels (p = 0.021) than those without delay. Regression analysis revealed a positive linear
relationship between PTH and serum calcium (y = 7.38 + 0.03x, R² = 0.429).
Conclusion: This study highlighted that disturbances in mineral metabolism, particularly hypocalcemia and compensatory
PTH elevation, are associated with delayed tooth eruption and dentine defects
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Copyright (c) 2026 Shakil Ahmed Shaikh , Sidra Jabeen, Aqeela Memon, Kalsoom Jawed, Muhammad Hanif, Hira Saeed Khan (Author)
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