Assessing the Predictive Value of Uterine Artery Flow Parameters in Patients with Recurrent Spontaneous Abortion
DOI:
https://doi.org/10.51985/Keywords:
Abortion, Miscarriages, Pregnancy Loss, Pulsatility Index, Resistive Index, Uterine artery flow parameters.Abstract
Objective: To compare uterine artery flow parameters in women with Recurrent Spontaneous Abortion (RSA) and a control group among females presenting at a tertiary care hospital.
Study Design and Settings: The study was conducted at the Department of Obstetrics and Gynecology for uterine artery flow parameters in women with Recurrent Spontaneous Abortion (RSA) and a control group.
Methodology: 100 participants were included, with 50 in each group. The case group comprised women with RSA, defined as three or more consecutive pregnancy losses before the 20th week of gestation, while the control group consisted of women with uncomplicated pregnancies and at least one child born at term. Data were collected on demographic and clinical variables, including age, parity, and BMI. Uterine artery flow parameters, including Pulsatility Index (PI) and Resistive Index (RI), were assessed via Doppler ultrasound, and the results were subjected to statistical analysis using SPSS.
Results: The study revealed that mean age, BMI, and median parity were similar in both groups. However, the PI and RI were significantly higher in the RSA group. The receiver operating characteristic (ROC) curve analysis demonstrated high diagnostic accuracy, with an area under the curve (AUC) of 88.6% for PI and 79.4% for RI, further emphasizing their potential as predictors of RSA.
Conclusion: Uterine artery blood parameters may serve as potential predictors for identifying women at risk of RSA.
References
1. El Hachem H, Crepaux V, May-Panloup P, Descamps P,
Legendre G, Bouet PE. Recurrent pregnancy loss: current
perspectives. Int J Womens Health 2017;9:331-45. DOI:
10.2147/ijwh.S100817.
2. Zhang X, Wang H, Feng T, Yang J, Huang Q, Lu C, et al. The
relationship between semen factors and unexplained recurrent
spontaneous abortion. Clin Chim Acta 2020;510:605-12. DOI:
10.1016/j.cca.2020.08.022.
3. Yasmeen R, Hussain R. Recurrent miscarriage and associated
factors. Pakistan Journal of Medicine and Dentistry
2016;5(1):47-50.4. Cao C, Bai S, Zhang J, Sun X, Meng A, Chen H. Understanding
recurrent pregnancy loss: recent advances on its etiology,
clinical diagnosis, and management. Med Rev (Berl)
2022;2(6):570-89. DOI: 10.1515/mr-2022-0030.
5. Lian X, Pan Z, Xia F, Mao C, Zhou W, Zhong Y, et al. Analysis
of the guidance and predictive value of uterine artery flow
parameters in patients with recurrent spontaneous abortion.
Journal of Obstetrics and Gynaecology Research
2023;49(3):803-11. DOI: https://doi.org/10.1111/jog.15523.
6. Frates MC, Doubilet PM, Brown DL, Benson CB, DiSalvo
DN, Laing FC, et al. Role of Doppler ultrasonography in the
prediction of pregnancy outcome in women with recurrent
spontaneous abortion. Journal of ultrasound in medicine
1996;15(8):557-62.
7. Wei LU, Honghong LIU, Weihao YANG. Predictive Value of
Uterine Artery Blood Flow Parameters in Early Pregnancy
on Adverse Pregnancy Outcomes in Patients with Recurrent
Spontaneous Abortion[J]. HeBei Med, 2021, 27(4): 579-583.
8. Sussman D, Saini BS, Schneiderman JE, Spitzer R, Seed M,
Lye SJ, Wells GD. Uterine artery and umbilical vein blood
flow are unaffected by moderate habitual physical activity
during pregnancy. Prenatal Diagnosis. 2019 Oct;39(11):976-
85.
9. Obeagu EI, Obeagu GU. Maternal Hypoxia: Impact on
Cardiovascular Health and Placental Function. Elite Journal
of Nursing and Health Science. 2024;2(8):50-65.
10. Voss P, Schick M, Langer L, Ainsworth A, Ditzen B, Strowitzki
T, Wischmann T, Kuon RJ. Recurrent pregnancy loss: a shared
stressor---couple-orientated psychological research findings.
Fertility and Sterility. 2020 Dec 1;114(6):1288-96.
11. Zhang K, Wang E, Li Y, Xu H, Zhang J, Wang X, et al. Role
of low-molecular-weight heparin in altering uterine artery
blood flow in recurrent spontaneous abortion: a prospective
study. J Int Med Res 2020;48(8):300060520945558. DOI:
10.1177/0300060520945558.
12. Lian X, Zhong Y, Lv X, Lu S, Lu Y, Zhou Y, et al. Doppler
evaluation of uterine blood flow and pregnancy outcome in
patients with URSA•FA retrospective cohort study. Research
Square; 2023.
13. Felisbino-Mendes MS, Matozinhos FP, Miranda JJ, Villamor
E, Velasquez-Melendez G. Maternal obesity and fetal deaths:
results from the Brazilian cross-sectional Demographic Health
Survey, 2006. BMC Pregnancy Childbirth 2014;14:5. DOI:
10.1186/1471-2393-14-5.
14. Eapen A, Hayes ET, McQueen DB, Beestrum M, Eyck PT,
Boots C. Mean differences in maternal body mass index and
recurrent pregnancy loss: a systematic review and metaanalysis of observational studies. Fertil Steril
2021;116(5):1341-8. DOI: 10.1016/j.fertnstert.2021.06.019.
15. Ghimire PR, Akombi-Inyang BJ, Tannous C, Agho KE.
Association between obesity and miscarriage among women
of reproductive age in Nepal. PLoS One 2020;15(8):e0236435.
DOI: 10.1371/journal.pone.0236435.
16. Cohain JS, Buxbaum RE, Mankuta D. Spontaneous first
trimester miscarriage rates per woman among parous women
with 1 or more pregnancies of 24 weeks or more. BMC
Pregnancy Childbirth 2017;17(1):437. DOI: 10.1186/s12884-
017-1620-1.
17. Yildiz G, Yavuzcan A, Yildiz P, Göynümer G, Yücel N. Effect
of uterine artery blood flow on recurrent pregnancy loss. Clin
Exp Obstet Gynecol 2012;39(3):326-9.
18. Taylor TJ, Quinton AE, de Vries BS, Hyett JA. First-trimester
ultrasound features associated with subsequent miscarriage:
A prospective study. Aust N Z J Obstet Gynaecol
2019;59(5):641-8. DOI: 10.1111/ajo.12944.
19. Elewa A, Mansour A, Gehad MA, Afify H. Ovarian reserve
testing and uterine blood flow assessment using twodimensional and three-dimensional Doppler in patients with
unexplained recurrent miscarriage. Benha Medical Journal
2017;34:81 - 7.
20. Wahab HA, El-Din DS, Zain E, Abdelgany M, Youssef
MAFM. Uterine artery Doppler and subendometrial blood
flow in patients with unexplained recurrent miscarriage.
Middle East Fertility Society Journal 2011;16(3):209-14.
DOI: https://doi.org/10.1016/j.mefs.2011.04.001.
21. Adekanmi AJ, Roberts A, Morhason-Bello IO, Adeyinka AO.
Utilization of Uterine and Umbilical Artery Doppler in the
Second and Third Trimesters to Predict Adverse Pregnancy
Outcomes: A Nigerian Experience. Womens Health Rep (New
Rochelle) 2022;3(1):256-66. DOI: 10.1089/whr.2021.0058.
22. Barati M, Shahbazian N, Ahmadi L, Masihi S. Diagnostic
evaluation of uterine artery Doppler sonography for the
prediction of adverse pregnancy outcomes. J Res Med Sci
2014;19(6):515-9.
23. Geerts L, Van der Merwe E, Theron A, Rademan K. Placental
insufficiency among high-risk pregnancies with a normal
umbilical artery resistance index after 32weeks. International
Journal of Gynecology & Obstetrics 2016;135(1):38-42. DOI:
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