Clinical Implication of Intraoperative Gallbladder Scoring Predicting the Need for Conversion from Laparoscopic Cholecystectomy to Open Cholecystectomy
DOI:
https://doi.org/10.51985/Keywords:
Laparoscopic cholecystectomy, open cholecystectomy, Nassar score, conversion, gallbladder scoringAbstract
Objective: To determine the association between intraoperative Nassar Difficulty Grade and conversion from laparoscopic to open cholecystectomy in adults undergoing laparoscopic cholecystectomy for benign gallbladder disease. Study Design & Setting: Prospective observational cohort study conducted in the Department of General Surgery, Pakistan Railways Hospital, Rawalpindi, from 9 February 2026 to 8 May 2026.
Methodology: Ninety-eight consecutive adults undergoing laparoscopic cholecystectomy for benign gallbladder disease were enrolled. Demographic, clinical, ultrasonographic, intraoperative and conversion data were recorded prospectively. Intraoperative difficulty was graded using the Nassar Difficulty Grading Scale. Grades I-II were categorized as low difficulty and Grades III-IV as high difficulty. Conversion proportions were compared using two-sided Fisher exact testing because of sparse cells, and a crude odds ratio (OR) with 95% confidence interval (CI) was calculated for high versus low Nassar grade. A p-value <0.05 was considered statistically significant.
Results: The mean age was 43.8 ± 13.2 years; 67/98 (68.4%) participants were female. Overall, 10/98 (10.2%) procedures were converted to open cholecystectomy. Conversion occurred in Grade I 1/34 (2.9%), Grade II 1/29 (3.4%), Grade III 3/21 (14.3%), and Grade IV 5/14 (35.7%). High difficulty (Grades III-IV) was associated with greater crude odds of conversion than low difficulty (Grades I-II): 8/35 (22.9%) versus 2/63 (3.2%); crude OR 9.04 (95% CI 1.80-45.41), Fisher exact p=0.004.
Conclusion: Higher intraoperative Nassar Difficulty Grade was associated with conversion to open cholecystectomy in this single-center observational cohort. The scale may support structured intraoperative assessment and communication, but the findings are unadjusted and should not be interpreted as evidence that Nassar grade independently predicts conversion
Downloads
References
1. Nassar AHM, Zanati HE, Ng HJ, Khan KS, Wood C. Open
conversion in laparoscopic cholecystectomy and bile duct
exploration: subspecialisation safely reduces the conversion
rates. Surg Endosc. 2022;36(1):550-558. doi: 10.1007/s00464-
021-08316-1
2. Morales-Maza J, Rodríguez-Quintero JH, Santes O, Aguilar
Frasco JL, Romero-Vélez G, García-Ramos ES, et al.
Conversion from laparoscopic to open cholecystectomy: risk
factor analysis based on clinical, laboratory, and ultrasound
parameters. Rev Gastroenterol Mex (Engl Ed). 2021;86(4):363-
369. doi: 10.1016/j.rgmxen.2021.08.001
3. Chin X, Mallika-Arachchige S, Orbell-Smith J, Wysocki AP.
Preoperative and intraoperative risk factors for conversion of
laparoscopic cholecystectomy to open cholecystectomy: a
systematic review of 30 studies. Cureus. 2023;15(10):e47774.
4. Wibowo AA, Putra OTJ, Helmi ZN, Poerwosusanta H, Utomo
TK, Sikumbang KM. A scoring system to predict difficult
laparoscopic cholecystectomy: a five-year cross-sectional
study. Minim Invasive Surg. 2022;2022:3530568.
5. Tongyoo A, Liwattanakun A, Sriussadaporn E,
Limpavitayaporn P, Mingmalairak C. The modification of a
preoperative scoring system to predict difficult elective
laparoscopic cholecystectomy. J Laparoendosc Adv Surg Tech
A. 2023;33(3):269-275. doi: 10.1089/lap.2022.0407
6. Paul S, Khataniar H, Ck A, Rao HK. Preoperative scoring
system validation and analysis of associated risk factors in
predicting difficult laparoscopic cholecystectomy in patients
with acute calculous cholecystitis: a prospective observational
study. Turk J Surg. 2022;38(4):375-381.
7. Ahmed N, ul Hassan M, Tahira M, Samad A, Rana HN. Intraoperative predictors of difficult cholecystectomy and
conversion to open cholecystectomy: a new scoring system.
Pak J Med Sci. 2018;34(1):62-66. doi: 10.12669/pjms.
341.13302.
8. Malik AM. Difficult laparoscopic cholecystectomies. Is
conversion a sensible option? J Pak Med Assoc. 2015;65(7):
698-700.
9. Ochoa-Ortiz LI, Cervantes-Pérez E, Ramírez-Ochoa S,
Gonzalez-Ojeda A, Fuentes-Orozco C, Aguirre-Olmedo I, et
al. Risk factors and prevalence associated with conversion of
laparoscopic cholecystectomy to open cholecystectomy: a
tertiary care hospital experience in Western Mexico. Cureus.
2023;15(9):e45720. doi: 10.7759/cureus.45720
10. Coaston TN, Vadlakonda A, Curry J, Mallick S, Le NK,
Branche C, et al. Association of severe obesity with risk of
conversion to open in laparoscopic cholecystectomy for acute
cholecystitis. Surg Open Sci. 2024;20:1-6. doi: 10.1016/j.sopen.
2024.05.005
11. Warcha³owski £, £uszczki E, Bartosiewicz A, Dereñ K,
Warcha³owska M, Oleksy £, et al. The analysis of risk factors
in the conversion from laparoscopic to open cholecystectomy.
Int J Environ Res Public Health. 2020;17(20):7571. doi:
10.3390/ijerph17207571
12. Sapmaz A, Karaca AS. Risk factors for conversion to open
surgery in laparoscopic cholecystectomy: a single center
experience. Turk J Surg. 2021;37(1):28-32. doi: 10.47717/
turkjsurg.2020.4734
13. Di Buono G, Romano G, Galia M, Amato G, Maienza E,
Vernuccio F, et al. Difficult laparoscopic cholecystectomy
and preoperative predictive factors. Sci Rep. 2021;11(1):2559.
doi: 10.1038/s41598-021-81938-6
14. Jang YR, Ahn SJ, Choi SJ, Lee KH, Park YH, Kim KK, et
al. Acute cholecystitis: predictive clinico-radiological
assessment for conversion of laparoscopic cholecystectomy.
Acta Radiol. 2020;61(11):1452-1462. doi: 10.1177/
0284185120906658
15. Rangel-Olvera G, Alanis-Rivera B, Trejo-Suarez J, GarciaMartin del Campo JN, Beristain-Hernandez JL. Intraoperative
complexity and risk factors associated with conversion to
open surgery during laparoscopic cholecystectomy in eight
hospitals in Mexico City. Surg Endosc. 2022;36(12):9321-
9328. doi: 10.1007/s00464-022-09206-w
16. Baral S, Chhetri RK, Thapa N. Utilization of an intraoperative
grading scale in laparoscopic cholecystectomy: a Nepalese
perspective. Gastroenterol Res Pract. 2020;2020:8954572.
doi: 10.1155/2020/8954572
17. Shrestha A, Bhattarai A, Tamrakar KK. Utility of the Parkland
Grading Scale to determine intraoperative challenges during
laparoscopic cholecystectomy: a validation study on 206
patients at an academic medical center in Nepal. Patient Saf
Surg. 2023;17(1):12. doi: 10.1186/s13037-023-00364-x
18. Kruthika S, Asuri K, Singh D, Prakash O, Rai S, Ramachandran
R, et al. Surgical Cholecystectomy Score (SCS) for grading
the difficulty of laparoscopic cholecystectomy. Langenbecks
Arch Surg. 2024;409(1):203. doi: 10.1007/s00423-024-03397-
7
19. Toro A, Teodoro M, Khan M, Schembari E, Di Saverio S,
Catena F, et al. Subtotal cholecystectomy for difficult acute
cholecystitis: how to finalize safely by laparoscopy-a systematic
review. World J Emerg Surg. 2021;16(1):45. doi: 10.1186/
s13017-021-00392-x
20. Chávez-Villa M, Dominguez-Rosado I, Figueroa-Méndez R,
De los Santos-Pérez A, Mercado MA. Subtotal
cholecystectomy after failed critical view of safety is an
effective and safe bail out strategy. J Gastrointest Surg.
2021;25(10):2553-2561. doi: 10.1007/s11605-021-04934-1
21. LeCompte MT, Robbins KJ, Williams GA, Sanford DE,
Hammill CW, Fields RC, et al. Less is more in the difficult
gallbladder: recent evolution of subtotal cholecystectomy in
a single HPB unit. Surg Endosc. 2021;35(7):3249-3257. doi:
10.1007/s00464-020-07759-2
22. Deng SX, Sharma BT, Ebeye T, Samman A, Zulfiqar A,
Greene B, et al. Laparoscopic subtotal cholecystectomy for
the difficult gallbladder: evolution of technique at a single
teaching hospital. Surgery. 2024;175(4):955-962. doi: 10.1016/
j.surg.2023.12.026
23. Haldeniya K, Krishna SR, Raghavendra A, Singh PK.
Laparoscopic subtotal cholecystectomy in difficult gallbladder:
our experience in a tertiary care center. Ann Hepatobiliary
Pancreat Surg. 2024;28(2):214-219. doi: 10.14701/ahbps.23-
168
24. Ie M, Katsura M, Kanda Y, Kato T, Sunagawa K, Mototake
H. Laparoscopic subtotal cholecystectomy after percutaneous
transhepatic gallbladder drainage for grade II or III acute
cholecystitis. BMC Surg. 2021;21(1):386. doi: 10.1186/s12893-
021-01387-w
25. Di Martino M, Mora-Guzmán I, Vaello Jodra V, Sanjuanbenito
Dehesa A, García Septiem J, Montalvá Orón E, et al.
Laparoscopic cholecystectomy for acute cholecystitis: is the
surgery still safe beyond the 7-day barrier? A multicentric
observational study. Updates Surg. 2021;73(1):261-272. doi:
10.1007/s13304-020-00924-1.
Downloads
Published
Issue
Section
License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Journal of Bahria University Medical & Dental College is an open access journal and is licensed under CC BY-NC 4.0. which permits unrestricted non commercial use, distribution and reproduction in any medium, provided the original work is properly cited. To view a copy of this license, visit https://creativecommons.org/licenses/by-nc/4.0