Role of Tranexamic Acid in Prevention of Seroma Formation after Ventral Herioplasty
DOI:
https://doi.org/10.51985/JBUMDC2025820Keywords:
ventral hernia repair, seromas, tranexamic acidAbstract
Objective: The aim of this study was to explore the role of tranexamic acid in prevention of seroma formation after ventral
herioplasty.
Study design and setting: The present cross-sectional study was carried out at the department of general surgery Bacha
Khan Medical Complex / Gajju Khan Medical College – SWABI from January 2025 to June 2025 after taking permission
from the research team of the hospital.
Method: In our study, Non-probability consecutive sampling approach was used for sample collection. A total of 100
individuals diagnosed with ventral hernia repair were included. All individuals were treated with the standard-only mesh.
A vacuum drain was used to measure the seroma's volume. One gram of intravenous tranexamic acid was administered
following skin closure, and 500 mg of oral tranexamic acid was administered for 12 hours on the 5th post-operative day.
On daily basis the drain output was recorded. When the output was less than 30 milliliters per day, the drain was removed.
SPSS version 24 was used for analysis of data.
Results: A total of 100 individuals participated in this study out of which 70(70%) were females and 30 (30%) were males.
The mean age of the study participants was 81.05±41.75 years. In 84 individuals (84%) the seroma resolved within five
days after surgery, but in 16 individuals (16%) it took longer than five day.
Conclusion: The current study concluded that Tranexamic acid significantly lowers the development of for seromas
following surgery ventral hernia repair.
References
1. Nixon SJ. Abdominal wall ernia and umbilicus. In:Williams
NS, Bulstrode CJK, O’Connell PR, editors, Bailey & Love’s
Short practice of Surgery.26th ed.CRC Press:Taylor & Francis
Group, LLC. 2020:pp948-69.
2. Primatesta P, Goldacre MJ. Inguinal hernia repair: incidence
of elective and emergency surgery, readmission and mortality.
Int J Epidemiol. 2017; 25:835-9. https://doi.org/10.1093/
ije/25.4.835
3. Schools IG, Van Dijkman B, Butzelaar RM, Van Geldere D,
Simons MP. Inguinal hernia repair in Amsterdam region.
Hernia. 2001;5:37-40. DOI: 10.1007/BF01576163
4. Tammam TF, Salama AF. Laparoscopic guided psoas blockade
as a novel analgesic method during inguinal herniorrhaphy:
a clinical trial. Acta Anaesthesiol Scand. 2017; 61:232-40.
doi: 10.1111/aas.12842
5. Gulzar MR, Iqbal J, Haq MI, Afzal M. Darning Vs Bassini
repair for inguinal hernia. Professional Med J. 2017; 14:128-
33.
6. Cho JE, Helm MC, Helm JH, Mier N, Kastenmeier AS, Gould
JC, et al. Retrorectus placement of bio-absorbable mesh
improves patient outcomes. Surg Endosc. 2019; 33:2629-34.
doi: 10.1007/s00464-018-6560-y.
7. Purushotham G, Revanth K, Aishwarya M.Surgical
management of umbilical and paraumbilical hernias. Int Surg
J.2019;4:2507-11. DOI:10.18203/2349-2902.isj20173384
8. Dayton MT, Beauchamp RD, Evers BM, Mattox KL, editors.
Sabistontext book of surgery, 17th edn. Elsevier: Saunders.
2014:pp-297-332.
9. Young DV. Comparison of local, spinal, and general anesthesia
for inguinal herniorrhaphy. Am J Surg. 2019;153:560-3. doi:
10.1016/0002-9610(87)90154-1.
10. Hübner M, Schäfer M, Raiss H, Demartines N, Vuilleumier
H. A tailored approach for the treatment of indirect inguinal
hernia in adults - an old problem revisited. Langenbeck's Arch
Surg. 2017;396:187-92.
11. Othman IH, Metwally YH. Comparative study between
laparoscopic and open repair ofparaumbilical hernia. J Egyptian
Soc Parasitol. 2019;42:175-82. doi: 10.12816/0006305.
12. Schlosser KA, Arnold MR, Otero J, PrasadT, Lincourt A,
Colavita PD, et al. Deciding on optimal approach for ventral
hernia repair: Laparoscopic or open. J Am Coll Surg.
2019;228:54-65. doi: 10.1016/j.jamcollsurg.2018.09.004
13. Ker K, Edwards P, Perel P, Shakur H,Roberts I. Effect of
tranexamic acid on surgical bleeding: systematic review and
cumulative meta-analysis. BMJ.2017;344:e3054. doi:
10.1136/bmj.e3054.
14. Ponten JEH, Somers KYA, Nienhuijs SW.Pathogenesis of
the epigastric hernia.Hernia. 2022;16:627-33. doi:
10.1007/s10029-012-0964-8.
15. Lashari, A., Mirani, S. H., Bozdar, A. G.,Shar, Z. A., And
Malik, A. (2020). Effectiveness of Tranexamic Acid for
Prevention of Post-operative Seroma Formation in Patients
Undergoing Ventral Hernioplasty. PAKISTAN JOURNAL
OF MEDICAL AND HEALTH SCIENCES 14, 1143-1145.
16. Cho, J. E., Helm, M. C., Helm, J. H., Mier, N.,
Kastenmeier, A. S., Gould, J. C., and Goldblatt, M. I.
(2019). Retro-rectus placement of bio-absorbable mesh
improves patient outcomes. Surgical Endoscopy 33, 2629-
2634 doi: 10.1007/s00464-018-6560-y
17. Othman, I., Metwally, Y., Bakr, I., Amer, Y., Gaber, M., and
Elgohary, S. (2012). Comparative study between laparoscopic
and open repair of paraumbilical hernia. J Egypt Soc
Parasitol 42, 175-182 doi: 10.12816/0006305.
18. Purushotham, G., Revanth, K., and Aishwarya, M. (2017).
Surgical management of umbilical and paraumbilical hernias.
International Surgery Journal 4, 2507-2511. DOI:10.18203/
2349-2902.isj20173384
19. Winkelmann, M., Friedrich, L., Schröter, C., Flemming,
A., Eismann, H., Sieg, L., Mommsen, P., Krettek, C., and
Zeckey, C. (2016). Simulator-based air medical training
program Christoph life: from concept to course. Air Medical
Journal 35, 242-246
20. Zubair, R., Mirza, M. R., Habib, L., & Zehra, B. (2020). Role
of tranexamic acid in prevention of seroma formation after
ventral hernioplasty. Pakistan Journal of Surgery, 36(2).
21. Tarar, J. M., Nadeem, K., Rashid, I., Naeem, M., & Ahmed,
R. (2023). Role of tranexamic acid in preventing.
DOI:10.54112/bcsrj.v2023i1.21121.
22. Slattery, C., Kark, J., Wagner, T., and Verma, K. (2019).
The use of tranexamic acid to reduce surgical blood loss.
Clinical Spine Surgery 32, 46-50
23. Seretis, K., Goulis, D., Demiri, E. C., and Lykoudis, E. G.
(2017). Prevention of seroma doi: 10.1093/asj/sjw192.
24. Bittner, R., Bain, K., Bansal, V., Berrevoet, F., BingenerCasey, J., Chen, D., Chen, J., Chowbey, P., Dietz, U., and
De Beaux, A. (2019). Update of Guidelines for laparoscopic
treatment of ventral and incisional abdominal wall hernias
(International Endohernia Society (IEHS))—Part A. Surgical
endoscopy 33, 3069-3139 doi: 10.1007/s00464-019-06907-
7.
25. Khan, R., Aalam, M., Ahmed, N., Pervaiz, M., and Saeed, Z.
Role of Tranexamic Acid for Seroma Prevention in Obese
Patients Undergoing Laparoscopic Ventral Hernia Repair
Under Spinal Anesthesia.
26. Poeran J, Rasul R, Suzuki S, Danninger T, Mazumdar M,
Opperer M, Boett ner F, Memtsoudis SG. Tranexamic acid
use and postoperative outcomes in patients undergoing total
hip or knee arthroplasty in the United States: retrospective
analysis of eff ectiveness and safet
Downloads
Published
Issue
Section
License
Copyright (c) 2026 Faiz ur Rahman, Aamir Ali Khan, Muhammad Kashif, Zia Ullah, Muhammad Ali, Muhammad Ibrahim Shuja (Author)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Journal of Bahria University Medical & Dental College is an open access journal and is licensed under CC BY-NC 4.0. which permits unrestricted non commercial use, distribution and reproduction in any medium, provided the original work is properly cited. To view a copy of this license, visit https://creativecommons.org/licenses/by-nc/4.0
