Mean Healing Time of Autologous PRP on Wounds in Terms of Split-Thickness Skin Graft Adhesion and Complications as Compared to Conventional Fixation Technique
DOI:
https://doi.org/10.51985/JBUMDC2025764Keywords:
Autologous PRP, Conventional Fixation, Haematoma, Seroma, Split Thickness Skin GraftAbstract
Objective: To compare mean healing time and complication rates in patients undergoing Split thickness skin grafting with
autologous PRP versus conventional fixation methods.
Study design and Setting: Two groups comprising of 50 patients (Total 100) in each undergoing split thickness skin
grafting were formed, Group A (PRP infiltration prior to STSG) and Group B (STSG with conventional fixation). Mean
healing time and graft take were the primary outcomes; infection, seroma, hemorrhage, and graft loss were the secondary
events.
Methodology: Non-probability consecutive sampling was used in a quasi-experimental study at PNS Shifa Hospital's
Plastic Surgery Department. One hundred patients with open wounds aged 18 and 60 years were randomly divided into
two groups by lottery method: Group B had STSG with conventional fixation, while Group A received autologous PRP
infiltration prior to STSG. Mean healing time and graft take were the primary outcomes; infection, seroma, hemorrhage,
and graft loss were secondary events.
Results: Mean healing time for Group A was 9.88 ± 1.56 days, substantially faster than that of Group B (mean 11.92 ±
2.68 days, p < 0.001). The PRP group's graft success rate was higher (85.17±9.83) than the control group (72.63±14.57).
Group A experienced significant decrease in complications such infection, seroma, and haematoma.
Conclusion: In patients undergoing STSG, autologous PRP significantly reduced the healing period and increased graft
success while lowering postoperative complications. It provides a biologically active substitute for traditional fixation
techniques.
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