Successful outcome of Treatment with Oxybutynin versus Imipramine in Children Presenting with Nocturnal Enuresis at Tertiary Care Hospital, Islamabad
DOI:
https://doi.org/10.51985/Keywords:
Enuresis; Imipramine; Nocturnal Enuresis; Oxybutynin; Treatment OutcomeAbstract
Objective: To compare the efficacy of oxybutynin and imipramine in children presenting with nocturnal enuresis. Study Design & Settings: Comparative interventional study, Department of Paediatrics, Pakistan Institute of Medical Sciences, Islamabad.
Methodology: A total of 598 children aged 5–14 years with nocturnal enuresis were allocated in equal numbers to oxybutynin or imipramine using sealed opaque envelopes and treated for 12 weeks. Group O received oxybutynin 5–15 mg/day and Group I received imipramine 25–75 mg/day. Participants were reviewed at week 6, and treatment response was defined as achievement of at least 2 consecutive dry weeks during the 12-week treatment period. The primary between-group comparison was supplemented with absolute risk difference, relative risk and odds ratio with 95% confidence intervals, while subgroup analyses were treated as exploratory.
Results: Mean age was 9.16 +/- 2.78 years in the oxybutynin group and 9.32 +/- 2.85 years in the imipramine group. The study-defined dryness outcome occurred in 209/299 (69.9%) children receiving oxybutynin and 185/299 (61.9%) receiving imipramine (p=0.038). The absolute difference was 8.0 percentage points (95% CI 0.5-15.6), relative risk 1.13 (95% CI 1.01-1.27), and odds ratio 1.43 (95% CI 1.02-2.01).
Conclusion: Oxybutynin produced a modestly higher short-term study-defined dryness rate than imipramine during the 12-week treatment period
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