Comparison of Intravenous Ciprofloxacin and Intravenous Ceftriaxone in the Management of Spontaneous Bacterial Peritonitis in Cirrhosis of Liver
DOI:
https://doi.org/10.51985/Keywords:
Peritonitis; Liver Cirrhosis; Ciprofloxacin; Ceftriaxone; Ascites.Abstract
Objective: To compare the effectiveness of intravenous ciprofloxacin versus intravenous ceftriaxone in spontaneous bacterial peritonitis (SBP) treatment of patients with liver cirrhosis.
Study Design and settings: Randomized controlled trial at Nishtar Hospital Multan/department of medicine.
Methodology: 310 patients aged 25-70 years old who are liver cirrhosed, diagnosed with SBP were enrolled using nonprobability consecutive sampling. Patients were randomly allocated to two groups using lottery approach. Group A (n=155) received the intravenous ciprofloxacin (200 mg twice a day) and Group B (n=155) the intravenous ceftriaxone (1 g twice a day). Efficacy was noted after 48 hours of treatment on the basis of: fever, abdominal pains, and decrease of the neutrophil count in the ascitic fluid; and data was analyzed using SPSS version 26 and chi-square test was applied and considered significant p<0.05.
Findings: Both groups showed an average age of 42.8 +- 9.6 years in Group A and 43.5 +-10.1 years in Group B and an overall efficacy of 71.0% for ciprofloxacin and ceftriaxone of 79.4% respectively and the difference was statistically significant (p=0.048). Ceftriaxone demonstrated superiority in clinical and lab outcome particularly among patients with advanced liver disease.
Conclusion: In comparison to intravenous ciprofloxacin, intravenous ceftriaxone is more effective in treatment of spontaneous bacterial peritonitis in cirrhosis.
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