Lisa vs Insure in the Treatment of Respiratory Distress Syndrome in Preterm Infants
DOI:
https://doi.org/10.51985/Keywords:
Intubate-surfactant-extubate: Less invasive surfactant administration: Preterm: Respiratory distress syndrome: Surfactant.Abstract
ABSTRACT
Objectives: To compare the outcome of Less Invasive Surfactant Administration (LISA) versus Intubation–Surfactant–Extubation (INSURE) for treatment of respiratory distress syndrome in preterm infants Study design and Setting: Randomized controlled trial, Department of Pediatric, Fauji Foundation Hospital Rawalpindi. March 27, 2022 till September 26, 2022 Subjects: Total 70 neonates aged 1 to 24 hours of life having gestational age of 32-36 weeks of either gender having respiratory distress syndrome were enrolled using non- probability consecutive sampling technique.
Methodology: Study was conducted after approval of hospital ethical committee and written informed consent of parents. Neonates were enrolled in LISA group A and INSURE group B using lottery method. In LISA group surfactant was given using 6Fr nasogastric tube and in INSURE group neonates were intubated and surfactant was given. Frequency of need for mechanical ventilation in both groups was noted. Data was entered and analyzed using SPSS 21.
Results: In our study total 70 patients were enrolled, 35 patients in each group. Mean age was 7.8±6.6 hours in group A and 6.6±5.9 in group B. There were 40% males in group A and 57.1% in group B. females were 60% in group A and 42.9% in group B. In LISA group 28.6% needed mechanical ventilation while in INSURE group 60% needed mechanical ventilation, p-value 0.008
Conclusion: LISA is more effective in preventing need for mechanical ventilation after surfactant administration in preterm neonates
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