Comparison of Metformin and Insulin in the Management of Non-Obese Gestational Diabetes Mellitus Patients
DOI:
https://doi.org/10.51985/Keywords:
Gestational Diabetes Mellitus, Hyperglycemia, Insulin, MetforminAbstract
Objective: This study will aim to determine the effects of metformin and insulin in the management of non-obese GDM. Study Design and setting: This Cohort study was carried out in the department of gynecology, Healthways Hospital Khyber Pakhtunkhwa (KPK) Pakistan. The duration of the study was 6 months started from May 2024 to Dec 2024. Methodology: Total 160 GDM patients were recruited which were divided equally in to two groups. To one group metformin 500mg thrice daily were prescribed while insulin (mixtard 70/30) was prescribed to insulin group. The target fasting blood sugar (FBS) was set <95mg/dl. All the patients were followed for 2 months with FBS after 1st week, 2nd week, 14 days and 1 month interval.
Results: In metformin group, 32.5% patients were in 1st trimester, 41.25% were in 2nd trimester while 41.25% were in 3rd trimester while in insulin group the frequency of 1st, 2nd and 3rd trimester was 33.75%, 52.5% and 13.75% respectively. The mean age, BMI and FBS in metformin group were 26.74±3.5 years, 24.18±2.21 and 135.16±9.74 mg/dl respectively. There were no statistical differences observed between mean values of both group with p-values 0.96, 0.73 and 0.87 respectively. However, in insulin group there was statistically significant difference achieved in controlling the FBS after two months with p-value 0.04.
Conclusion: Insulin significantly controls the FBS but metformin also shows comparable results. Thus, metformin is a good first line drug in terms of cost and compliance to GDM patients especially in financially deprived area.
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