Diagnostic Accuracy of Twinkling Artefect in Diagnosis of Ureteric Calculus Keeping Non-Contrast CT as A Gold Standard

Authors

  • Naveed Hussain Author
  • Usman Shakil Author
  • Sana Sharif Author
  • Mohammad Uzair Author
  • Nosheen Sadiq Author
  • Muhammad Saeed Author

DOI:

https://doi.org/10.51985/JBUMDC2025660

Keywords:

Accuracy, Doppler ultrasound, Non contrast enhanced CT, Sensitivity, Specificity, Twinkling artifact, Ureteric stones

Abstract

 Objective: To determine the diagnostic accuracy of the twinkling artifact on Doppler ultrasound using non-contrast CT
as the gold standard for detecting ureteric stones.
Study Design & Setting: This cross-sectional diagnostic accuracy study was conducted at the Department of Radiology,
a tertiary care hospital, from 2 October 2021 to 1April 2022.
Methodology: A total of 141 patients with clinically suspected ureteric colic were enrolled. All underwent Doppler
ultrasound followed by Non contrast enhanced CT. Findings of twinkling artifact were recorded and compared with Non
contrast enhanced CT outcomes. Diagnostic parameters including sensitivity, specificity, positive predictive value (PPV),
negative predictive value (NPV), and accuracy were calculated. Subgroup analysis was performed based on age, gender,
and stone size.
Results: The mean age was 38.59 ± 9.97 years; 55.3% were male. The twinkling artifact was observed in 94 (66.7%)
patients. Non contrast enhanced CT confirmed ureteric stones in 81 (57.4%) cases. Sensitivity, specificity, PPV, NPV, and
overall accuracy of the twinkling artifact were 90.1%, 93.3%, 94.8%, 87.5%, and 91.5%, respectively. Stratified analysis
showed diagnostic accuracy above 89% across all subgroups.
Conclusion: The twinkling artifact on Doppler ultrasound demonstrated excellent diagnostic accuracy and can be considered
a reliable, radiation-free alternative to Non contrast enhanced CT for detecting ureteric stones. 

References

1. Szymanski J, Chlosta M, Dudek P, Rajwa P, Krajewski W,

Bryniarski P, et al. Prevalence, correlates, and treatment

behaviors for urolithiasis and renal colic-like pain symptoms

at the population level in Poland. Sci Rep. 2025;15(1):10827.

doi.org/10.1038/s41598-025-95504-x

2. Nassir AM. Prevalence and characterization of urolithiasis in

the Western region of Saudi Arabia. Urol Ann. 2019;11(4):347-

52. doi.org/10.4103/UA.UA_56_19

3. Awedew AF, Han H, Berice BN, Dodge M, Schneider RD,

Abbasi-Kangevari M, et al. The global, regional, and national

burden of urolithiasis in 204 countries and territories,

2000–2021: a systematic analysis for the Global Burden of

Disease Study 2021. EClin Med. 2024;78.

doi.org/10.1016/j.eclinm.2024.102924

4. Hussain M, Somro AS, Abidi SS, Rizvi SA. Stepping Stones

In Prevention of Kidney Stone Disease In Pakistan. Pak J

Kidney Dis. 2024;8(2):2-10. DOI: 10.53778/pjkd82259

5. Al-Shawi MM, Aljama NA, Aljedani R, Alsaleh MH, Atyia

N, Alsedrah A, Albardi M, Al-Shawi M. The role of radiological

imaging in the diagnosis and treatment of urolithiasis: a

narrative review. Cureus. 2022 Dec 28;14(12):33041. doi:

10.7759/cureus.33041

6. Eleraky AM, Yassin AE, ElSharkawy MK. Comparison

Between Ultrasonography and MultiDetector Computed

tomography in evaluation of Acute Abdomen. Al-Azhar

International Medical Journal. 2024;5(7):45. DOI:

https://doi.org/10.58675/2682-339X.2563

7. Cosmai L, Porta C, Privitera C, Gesualdo L, Procopio G, Gori

S, Laghi A. Acute kidney injury from contrast-enhanced CT

procedures in patients with cancer: white paper to highlight

its clinical relevance and discuss applicable preventive

strategies. ESMO open. 2020 Jan 1;5(2):e000618.

https://doi.org/10.1136/esmoopen-2019-000618

8. Gulzar L, Zubair M, Tariq M, Tahir F, Ahmad A, Wareed Z,

Khan M. B-Mode Sonography Versus Color Doppler Twinkling

Artifact in the Diagnosis of Nephrolithiasis. Journal of Health

and Rehabilitation Research. 2024 Apr 8;4(2):38-42.

doi.org/10.61919/jhrr.v4i2.736

9. AlSaiady M, Alqatie A, Almushayqih M. Twinkle artifact in

renal ultrasound, is it a solid point for the diagnosis of renal

stone in children?. Journal of ultrasonography. 2021 Dec

15;21(87):e282. doi: 10.15557/JoU.2021.0048

10. Gliga ML, Chirila CN, Podeanu DM, Imola T, Voicu SL,

Gliga MG, et al. Twinkle, twinkle little stone: an artifact

improves the ultrasound performance!. Medical

ultrasonography. 2017;19(3):272-5. doi.org/10.11152/mu-984

11. Buderer NM. Statistical methodology: I. Incorporating the

prevalence of disease into the sample size calculation for

sensitivity and specificity. Acad Emerg Med. 1996 Sep; 3(9):

895-900. doi: 10.1111/j.1553-2712.1996.tb03538.x. PMID:

8870764

12. Cervellin G, Mora R, Ticinesi A, Meschi T, Comelli I, Catena

F, et al. Epidemiology and outcomes of acute abdominal pain

in a large urban emergency department: retrospective analysis

of 5,340 cases. Ann Transl Med. 2016;4(19). doi:

10.21037/atm.2016.09.10

13. Abid A, Butt RW, Abbas HB, Niazi M, Alam S, Shakil H.

Diagnostic accuracy of colour doppler ultrasound using

twinkling artefact for the diagnosis of renal and ureteric calculi

keeping non enhanced CT KUB as gold standard. PAFMJ.

2021;71(2):522-25.

14. Tariq R, Nadeem SF, Tahir HB, Hasnain AZ, Iftikhar A, Khan

W. Comparison of Diagnostic Accuracy of Colour Doppler

Twinkling Artefact with Computed Tomography of the Kidney,

Ureters, and Bladder in Detection of Nephrolithiasis in Emergency

Setup-Point of Care Ultrasonography. Pakistan Armed Forces

Medical Journal. 2024 Feb 29;74(1):104. https://doi.org/

10.51253/pafmj.v74i1.10304

15. Khan A. The Diagnostic Accuracy of Sonographic Twinkling

Artefact in Localization of Ureteric Stones Keeping Low

Dose Computed Tomography as the Gold Standard. Esculapio.

2024;20(01):101-103. https://doi.org/10.51273 /esc24.2

51320120

16. Adel H, Sattar A, Rahim A, Aftab A, Adil SO. Diagnostic

accuracy of doppler twinkling artifact for identifying urinary

tract calculi. Cureus. 2019 Sep 13;11(9):e5647. doi: 10.7759/

cureus.5647

17. Hanafi MQ, Fakhrizadeh A, Jaafaezadeh E. An investigation

into the clinical accuracy of twinkling artifacts in patients

with urolithiasis smaller than 5 mm in comparison with

computed tomography scanning. Journal of Family Medicine

and Primary Care. 2019 Feb 1;8(2):401-6. https://doi.org/

10.4103/jfmpc.jfmpc_300_18

18. Arshad S, Ashraf R, Farooq F, Haq MM. Diagnostic accuracy

of Twinkling Artifact in detection of nephrolithiasis with CTKUB as Gold Standard. Rawal Medical Journal. 2021 Oct

14;46(4):830-.

19. Memon SA, Sahito AA, Suhail MA, Ashraf AI, Kumari SH,

Ali KA. Diagnostic accuracy of ultrasound in detection of

ureteric calculi taking CT KUB as gold standard. Pakistan

Journal of Medical and Health Sciences. 2021;15(4):1349-

51.

20. Shuja MK, Wahid G, Bashir F, Jawaid A, Khan S, Amjad A.

Diagnostic Accuracy of Twinkling Artifact of Doppler

Ultrasound in Predicting Urinary Tract Calculi Taking Ct

Scan As Gold Standard. Journal of Gandhara Medical and

Dental Science. 2025 Mar 31;12(2):34-8. DOI:10.37762/

jgmds.12-2.652

21. Lalchan S, Sharma P, KC S, Gyawali M, Poudel A. Diagnostic

accuracy of Ultrasonography in detecting ureteric calculi in

patients with renal colic taking Non-Contrast Multidetector

Computerized Tomography of Kidney, Ureter, and Bladder

(CT KUB) as the gold standard.Nepal Journal of Medical

Sciences. 2022;7(1):56-61. DOI:10.3126/njms.v7i1.44589

22. Rasul T, Latif A, Rehman T, & Bano A. (2025). Diagnostic

Accuracy of Twinkling Artefact on Color Doppler Ultrasound

to Diagnose Urinary Tract Stones taking Unenhanced CTKUB as Gold Standard. Indus Journal of Bioscience Research,

3(4), 858- 861. https://doi.org/10.70749 /ijbr.v3i4. 197223.

23. Rashid A, Iqbal I, Khan A, Sheharyar Aamir H, Saeed S, &

Arsalan Omer M. (2024). The Diagnostic Accuracy of

Sonographic Twinkling Artefact in Localization of Ureteric

Stones Keeping Low Dose Computed Tomography as the

Gold Standard. Esculapio Journal of SIMS, 20(1), 100–103.

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Published

2026-01-14

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