Impact of Radical and Partial Nephrectomy on Renal Function Outcome
DOI:
https://doi.org/10.51985/Keywords:
CKD (chronic kidney disease); eGFR (estimated glomerular filtration rate); PN (Partial Nephrectomy); RCC (Renal cell carcinoma); RN (Radical Nephrectomy)Abstract
Objective: To evaluate renal function outcomes and new-onset CKD in patients undergoing radical nephrectomy (RN) or partial nephrectomy (PN).
Methodology: In this prospective cohort study, 204 renal tumor patients underwent RN or PN, eGFR was recorded preoperatively and up to 1 year postoperatively. Variables included age, gender, surgery type, and eGFR values. Data were analyzed using IBM SPSS 20. Continuous variables were reported as mean, median, SD, and IQR; categorical variables as frequencies and percentages. Student’s t-test, chi-square, and multivariate analysis were applied. p<0.05 was significant. Results: Of 204 patients, 154 (75.5%) had RN and 50 (24.5%) had PN. Mean age was 50.41±12.21 years. Baseline median eGFR was lower in RN (82.46 mL/min/1.73m²; IQR 74.98–93.31) than PN (88.44; IQR 79.07–101.61, p<0.002). At 72 hours, RN median eGFR was 63.03 (IQR 53.78–73.08) vs PN 78.23 (IQR 64.87–94.75, p<0.001). At 1 month, RN: 59.93 (IQR 48.87–70.58) vs PN: 76.72 (IQR 61.43–94.97, p<0.001). At 6 months, RN: 57.48 (IQR 46.36–67.21) vs PN: 73.98 (IQR 62.66–87.51, p<0.001). At 1 year, RN: 58.41 (IQR 46.24–67.66) vs PN: 74.40 (IQR 63.09–90.45, p<0.001). Conclusion: Partial nephrectomy, when feasible, better preserves renal function than radical nephrectomy and should be preferred for suitable kidney tumors
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