Effect of Preoperative Steroid Injection on Wound Drainage after Modified Radical Mastectomy
DOI:
https://doi.org/10.51985/JBUMDC2025816Keywords:
Steroid injections; Mastectomy; drainage volumeAbstract
Objective: The aim of this study was to determine the Effect of Preoperative Steroid Injection on Wound Drainage after
Modified Radical
Study design and setting: The current Quasi-experimental study was carried out at the department of surgery Ibn e siena
hospital and research institute Multan and Bakhtawar Ameen Medical and Dental College Multan for a period of six months
from January, 2023 -June, 2024 after taking permission from the ethical board of the hospital.
Methodology: A total of 62 females with breast cancer, planned for modified radical mastectomy were included. The
patients were assigned computer-generated numbers to form two equal groups, A and B. An hour before to surgery, group
A received a 120 mg a day (3 ml) injection of depomedrol, while group B received 3 ml of regular saline. The same
consultant surgeon conducted MRM on both groups using the same dissection technique, which is steel scalpel dissection.
Two suction drains, one at the breast site and one at the axillary area, were positioned at the end of the treatment. Data
was analyzed through SPSS 25.
Results: In our study, 48.3% females were diagnosed with stage II, and 51.7% had stage I breast cancer. In a modified
radical mastectomy, a single preoperative steroid dose reduced mean drainage volume more than control. (P=0.048).
Conclusion: Our findings showed that that the preventive steroid injections prescription in women following modified
radical mastectomy were more effective in lowering mean drainage volume for female participants with stage I and II breast
cancer when compared to normal saline
References
1. Akram M, Iqbal M, Daniyal M, Khan AU. Awareness
and current knowledge of breast cancer. Biol Res.
2017;50(1):33. https://doi.org/10.1186/s40659-017-0140-9
2. Khan MA. Effect Of Preoperative Intravenous Steroids
On Seroma Formation After Modified Radical Mastectomy.
Journal of Ayub Medical College, Abbottabad: JAMC.
2017;29(2):207-10.
3. Kong D, Liu Y, Li Z, Cui Q, Wang K, Wu K, et al. OK-432
(Sapylin) Reduces Seroma Formation After Axillary
Lymphadenectomy in Breast Cancer. J Invest Surg.
2017;30(1):1-5. doi: 10.1080/08941939.2016.1204386
4. Masud Rana AM, Ahmed SU, Alam F, Joardar AI,
Chowdhury AK, Bari MA, et al. Electrosurgery Dissection
versus Sharp Dissection: Effect on Early Postoperative
Wound Complications in Modified Radical Mastectomy.
Mymensingh medical journal: MMJ. 2019;28(3):634-40
5. Michalik T, Matkowski R, Biecek P, Szynglarewicz B.
The use of ultrasonic scalpel lowers the risk of postmastectomy seroma formation in obese women. J Cancer.
2019;10(15):3481-85. DOI: 10.7150/jca.29774
6. Najeeb E, Rashid R, Zaffar S. Effect of Flap Fixation
Technique in Modified Radical Mastectomy on Incidence
of Postoperative Seroma Formation. Journal of the College
of Physicians and Surgeons--Pakistan : JCPSP.
2019;29(5):410-13. DOI: 10.29271/jcpsp.2019.05.410
7. Watt-Boolsen S, Nielsen VB, Jensen J, Bak S. A study of the
nature and origin of seroma after mastectomy. Dan Med
Bull. 1989;36(5):487–9.
8. Aitken DR, Minton JP. Complications associated with
mastectomy. Surg Clin North Am. 1983; 63(6):1331–52.
https://doi.org/10.1016/S0039-6109(16)43192-0
9. Axelsson CK, Quamme GM, Lanng C, Szecsi PB,
Mortensen MB, Wegeberg B, et al. Local injection of
methylprednisolon acetate to prevent seroma formation
after mastectomy. Dan Med J. 2012;59(9):A4482. https://doi.
org/10.1002/bjs.9874
10. Qvamme G, Axelsson CK, Lanng C, Mortensen M,
Wegeberg B, Okholm M, et al. Randomized clinical trial
of prevention of seroma formation after mastectomy by
local methylprednisolone injection. Br J Surg. 2015;102(10):
1195–203. https://doi.org/10.1002/bjs.9874
11. Vijayalakshmi S. Acomprehensive study on the effect of
injection methylprednisolone in post mastectomy seroma.
IAIM. 2018;5:43-7.
12. Tahmasebi S, Amirian A, Talei A. Axillary dissection in
44 breast cancer patients without seroma formation.
Middle East Journal of Cancer. 2011; 2(2): 65-69.
13. Talha A, Ramadan R, Abdelhamid S, Hamdi S.
Postmastectomy seroma: how much is it affected by serum
levels of IL-6 and CRP and how much is it reduced by
intravenous hydrocortisone injection?. The Egyptian Journal
of Surgery. 2015; 34(1):17.
14. H Turner EJ, Benson JR, Winters ZE. Techniques in the
prevention and management of seromas after breast surgery.
Future oncology. 2014 ;10(6):1049-63. https://doi.org/10.2217/
fon.13.257
15. Turel KS, Dilek ON, Akbulut G, Sahin DA, Ozenc E,
Yazicioglu MB. Effects of local anti-inflammatory drugs
on seroma formation after mastectomy and axillary lymph
node dissection in the rat model. Natl J Med Res. 2014;4(3):
228–31.
16. Kjetil H, Sem TK, Ellen S, Johan R. The prolonged
postoperative analgesic effect when dexamethasone is
added to a nonsteroidal antiinflammatory drug (rofecoxib)
before breast surgery. Anesthesia & Analgesia. 2007
;105(2):481-6.
17. Wolde B, van den Wildenberg FJ, Keemers-Gels ME,
Polat F, Strobbe LJ. Quilting Prevents seroma formation
following breast cancer surgery: closing the dead space by
quilting prevents seroma following axillary lymph node
dissection and mastectomy. Ann Surg Oncol. 2014
;21(3):802–7. DOI: 10.1245/s10434-013-3359-x
18. Szecsi PB, Larsen J, Hørby J, Axelsson CK. Seroma Production
after Breast Cancer Surgery has a ProInflammatory
Component. Open Breast Cancer J. 2012;4(1):11–7. https://
doi.org/10.2174/1876817201204010011
19. Taghizadeh R, Shoaib T, Hart AM, Weiler-Mithoff EM.
Triamcinolone reduces seroma re-accumulation in the
extended latissimus dorsi donor site. J Plast Reconstr Aesthet
Surg 2008; 61: 636–642. DOI: 10.1016/j.bjps.2007.03.019
20. Okholm M, Axelsson CK. No effect of steroids on seroma
formation after mastectomy. Dan Med Bull. 2011 ;58(2):A424
21. Wu X, Luo Y, Zeng Y, Peng W, Zhong Z. Prospective
comparison of indwelling cannulas drain and needle aspiration
for symptomatic seroma after mastectomy in breast cancer
patients. Arch Gynecol Obstet. 2020; 301:283-7. doi:
10.1007/s00404-019-05396-2.
22. Lembo F, Cecchino LR, Parisi D, Portincasa A. Reduction of
seroma and improvement of quality of life after early drain
removal in immediate breast reconstruction with tissue
expander. Preliminary report from a randomized controlled
study. J Plast Reconstr Aesthet Surg. 2021; 74:2565-72. doi:
10.1016/j.bjps.2021.02.005
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Copyright (c) 2026 Asma Aziz, Muhammad Waqas Arshad, Muhammad Shahzeb Asghar (Author)
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