Association of Obesity with Outcomes in Patients with Chronic Kidney Disease
DOI:
https://doi.org/10.51985/JBUMDC2025749Keywords:
Body Mass Index, Diabetes Mellitus, Hypertension, Kidney Disease, Mortality, ObesityAbstract
Objective: The present study was designed to clarify the impact of obesity with outcomes among hospitalized patients
with chronic kidney disease (CKD).
Study design and setting: A 6 months prospective cohort study from From April to September 2024, which took place
in the Department of Medicine, Aga Khan University Hospital, Karachi Pakistan.
Methodology: The patients were enrolled from inpatient and outpatient medical wards of AKUH and 200 hospitalized
CKD patients were recruited and divided equally into obese (BMI >30 kg/m²) and non-obese (BMI <30 kg/m²) groups.
Baseline characteristics were contrasted, and 30-day in-hospital mortality was assessed. We conducted subgroup analyses
for age, sex, diabetes and hypertension. p-values were computed by SPSS version 25 and the results of = 0.05 determined
significance.
Results: Compared with non-obese patients, obese patients were younger, more likely to be male, and had a higher mean
estimated glomerular filtration rate (eGFR). Diabetes occurred less frequently in the obese group (21% vs 47%) and
hypertension was present in both groups. Obese patients had a 7% 30-day mortality compared to 3% for non-obese patients
[RR = 2.33 (p =.20)]. The risk of mortality was higher in women, younger individuals and those with diabetes but the
associations did not reach statistical significance.
Conclusions: Obesity was significantly associated with increased short-term mortality in hospitalized CKD patients,
especially for women and diabetics.
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