Effect of Ginger-Naproxen on Knee Osteoarthritis: A Clinical Study

Authors

  • Mehtab Munir
  • Khalid Mustafa Memon
  • Sajid Abbas Jaffri
  • Hasan Ali

DOI:

https://doi.org/10.51985/FAGQ7533

Keywords:

Ginger, Knee osteoarthritis, Naproxen, Pain, Stiffness, WOMAC score

Abstract

Objective: To evaluate clinical efficacy and safety of ginger with naproxen, in treating knee osteoarthritis.
Study design and setting: Randomized clinical trial conducted in medicine department OPD of National Medical Center,
Karachi from 21st September 2018 till 31st March 2019.
Methodology: This study was conducted on 60 patients of knee osteoarthritis. After written informed consent, the patients
were randomized to two groups. Group A received tablet naproxen 500mg and capsule ginger 550mg, twice daily and group
B was given tablet naproxen 500mg twice daily. Total 53 patients finished the study (group A: n=27 and group B: n=26).
Baseline pain (Visual Analogue Scale) and Western Ontario and McMaster Universities Osteoarthritis index (WOMAC)
scores were noted at the beginning of study and reassessed after 6 weeks of the intervention. Safety profile of the drugs
was assessed by observing adverse effects. Independent t-test was applied to check difference between the two groups.
Statistical analysis was performed using SPSS version 23.0. P-value < 0.05 was considered as statistically significant.
Results: Before the intervention no significant difference was observed in two groups. However significant difference was
observed between the groups in pain (p=0.019) and WOMAC (p=0.020) scores after 6 weeks of intervention. Moreover
there was no significant difference (p=0.914) in occurrence of adverse effects between the two groups at the end of 6 weeks
of study.

References

Mobasheri A, Bay-jensen A, van Spil WE, Larkin J, Levesque MC. Osteoarthritis Year in Review 2016?: biomarkers ( biochemical markers ). 2017;25(2):199–208. doi: 10.1016/j. joca.2016.12.016.

WHO / chronic rheumatic conditions. Available from http:// www.who.int/chp/topics/rheumatic/en/ (cited on 15 July 2019).

Akhter E, Bilal S, Kiani A, Haque U. Prevalence of arthritis in India and Pakistan: A review. Rheumatol Int. 2011; 31(7) :849–855.

Cross M, Smith E, Hoy D, Nolte S, Ackerman I, Fransen M, et al. The global burden of hip and knee osteoarthritis: Estimates from the Global Burden of Disease 2010 study. Ann Rheum Dis. 2014;73(7):1323–1330.

Rahmati M, Mozaffri M. The Association between Osteoarthritis and Osteoporosis: In Bad Company? J Osteopor Phys. 2015; 3(2):134-139.

La Porta C, Bura SA, Negrete R, Maldonado R. Involvement of the endocannabinoid system in osteoarthritis pain. Eur J Neurosci. 2014;39(3):485–500.

Alshami AM. Knee osteoarthritis related pain?: a narrative review of diagnosis and treatment. Int J Health Sci. 2014; 8(1):85-104.

Pereira D, Ramos E, Branco J. Osteoarthritis. Acta Med Port, 2015; 28(1): 99–106.

McAlindon TE, Bannuru RR, Sullivan MC, Arden NK, Berenbaum F, Bierma-Zeinstra SM, et al. OARSI guidelines for the non-surgical management of knee osteoarthritis. Osteoarthr Cartil. 2014; 22(3):363–388.

Sanders D, Krause K, O'Muircheartaigh J, Thacker MA, Huggins JP, Vennart W, etal. Pharmacologic modulation of hand pain in osteoarthritis: A double blind placebo-controlled functional magnetic resonance imaging study using naproxen. Arthri & Rheumatol. 2015; 67(3): 741–751.

Wang C, Wang F, Lin F, Duan X, Bi B. Naproxen attenuates osteoarthritis progression through inhibiting the expression of prostaglandin-endoperoxide synthase 1. J Cell Physiol. 2019; 234 (8): 12771–12785.

Therkleson T. Topical ginger treatment with a compress or patch for osteoarthritis symptoms. J Holist Nurs. 2014; 32(3)173–182.

Farzaei MH, Farzaei F, Gooshe M , Abbasabadi Z, Rezaei N, Abdolghaffari AH. Potentially effective natural drugs in treatment for the most common rheumatic disorder: osteoarthritis. Rheumatol Int. 2015; 35(5):799-814.

Tanaka K, Arita M, Sakurai H, Ono N, Tezuka Y. Analysis of Chemical Properties of Edible and Medicinal Ginger by Metabolomics Approach. Biomed Res Int. 2015; 14(1): 1155-1162. doi: 10.1155/2015/671058.

Aborehab NM, El Bishbishy MH , Refaiy A, Waly NE. A putative Chondroprotective role for IL-1 â and MPO in herbal treatment of experimental osteoarthritis. Alt Med.2017; 17(1): 495-504.

Pal CP, Singh P, Chaturvedi S, Pruthi KK, Vij A. Epidemiology of knee osteoarthritis in India and related factors. Ind J Orthop. 2016; 50(5): 518–522.

Prashansanie Hettihewa A, Gunawardena NS, Atukorala I, Hassan F, Lekamge IN, Hunt DJ. Prevalence of knee osteoarthritis in a suburban, Srilankan, adult female population: a population-based study. Int J Rheum Dis. 2018; 21(2): 394-401. doi: 10.1111/1756-185X.13225.

Alipour Z, Asadizaker M, Fayazi S, Yegane N, Kochak M, Hossein M, et al. The Effect of Ginger on Pain and Satisfaction of Patients with Knee Osteoarthritis. Jundishapur J Chronic Dis Care. 2017; 6(1) e34798. doi: 10.17795/jjcdc-34798.

Paramdeep G. Efficacy and tolerability of ginger (Zingiber officinale) in patients of osteoarthritis of knee. Indian J PhysiolPharmacol. 2013; 57(2):177–183.

Bartels EM, Folmer VN, Bliddal H, Altman RD, Juhl C, Tarp S, et al. Efficacy and safety of ginger in osteoarthritis patients: A meta-analysis of randomized placebo-controlled trials. Osteoarthr Cartil .2015; 23(1):13–21.

Naderi Z, Mozaffari-khosravi H, Dehghan A, Nadjarzadeh A, Huseini HF. Effect of ginger powder supplementation on nitric oxide and C-reactive protein in elderly knee osteoarthritis patients: A 12-week double-blind randomized placebo-controlled clinical trial. J Tradit Complement Med. 2016; 6(3): 199–203.

Mozaffari-khosravi H, Naderi Z, Dehghan A, Nadjarzadeh A, Huseini HF. Effect of Ginger Supplementation on Proinflammatory Cytokines in Older Patients with Osteoarthritis?: Outcomes of a Randomized Controlled Clinical Trial. J Nutr Gerontol Geriatr. 2016; 35(3): 209-218.

Srinivasan K. Ginger rhizomes ( Zingiber officinale ): A spice with multiple health beneficial potentials. Phar Nutri. 2017; 5(1):18-28. doi: 10.1016/j.phanu.2017.01.001.

Vaishya R, Agarwal AK, Shah A, Vijay V, Vaish A. Current status of top 10 nutraceuticals used for Knee Osteoarthritis in India. J Clin Orthop Trauma. 2018; 9 (4): 338-348.

Downloads

Published

2021-03-02

How to Cite

Munir, M. ., Memon, K. M. ., Jaffri, S. A., & Ali, H. . (2021). Effect of Ginger-Naproxen on Knee Osteoarthritis: A Clinical Study. Journal of Bahria University Medical and Dental College, 11(1), 17–21. https://doi.org/10.51985/FAGQ7533

Issue

Section

Original Articles

Most read articles by the same author(s)