Association Of Vitamin D Status And Diabetes Mellitus

Authors

  • Aamir Ijaz
  • Shagufta Yousaf
  • Muhammad Zafar Ali
  • Sikandar Hayat Khan
  • Sohail Sabir
  • Humaira Asif
  • Muhammad Jaleel Anwar
  • Najm-Us-Saqib Khan

Keywords:

Vitamin D3; Diabetes mellitus; Association; risk factor

Abstract

To evaluate the association of 25-hydroxyvitamin D3 (25OHD)inadequacyand hyperglycaemia in a Pakistani adult population.
Study Design:Case control study
Place & Period of Study:Department of Pathology, PNS SHIFA Hospital, Karachi; Aug 2011 to Nov 2011.
Method and Material:Plasma Glucose levels were measured in 86 patients divided on the basis of their 25-hydroxyvitamin D3
(25OHD)levels in three groups, normal (>31 ng/ml), insufficient (20-31ng/ml) and deficient (<20ng/ml). Vitamin D insufficiency (VDI)
and Vitamin D Deficiency (VDD) are collectively called Vitamin D inadequacy. 25OHD was measured by electrochemiluminescence
using Roche Elecsys® Systems while glucose was estimated by routine methods on Roche Hitachi® Autoanalyser.
Results:.Vitamin D levels were inversely correlated with plasma glucose levels(r=-0.38;p<0.01) with an Odd Ratio of 3.59
(95%confidence interval 1.29 to 8.70).Fasting plasma glucose was significantly higher in VDD patientsas compared to patients with
normal vitamin D status (p<0.05).
Conclusion:Higher glucose levels were found more frequent in patients with Vitamin D deficiency.

References

Prentice A. Vitamin D deficiency: a global perspective: Nutrition Reviews 2008; 66:(2):S153-4.

Holick MF. High Prevalence of Vitamin D Inadequacy and Implications for Health. Mayo Clin Proc. 2006;81(3):353-73.

Zuberi LM, Habib A, Haque N et al. Vitamin D Deficiency in Ambulatory patients. J Pak Med Assoc 2008;58(9):482-4.

Iqbal R, Khan AH. Possible causes of vitamin D deficiency in Pakistani population residing in Pakistan: J Pak Med Assoc 2010;60(1):1-2.

Danescu LG, Levy S, Levy J. Vitamin D and diabetes mellitus: Endocr 2009; 35(1):11–17.

Mathieu C, Gysemans C, Giulietti A et al. Vitamin D and diabetes. Diabetologia 2005;48:1247–57.

Forouhi NG, Luan J, Cooper A et al. Baseline serum 25-hydroxy vitamin D is predictive of future glycemic status and insulin resistance. The Medical Research Council Ely Prospective Study 1990 – 2000. Diabetes 2008;57:2619–25.

Scragg R, Sowers MF, Bell C. Serum 25-Hydroxyvitamin D, Diabetes, and Ethnicity in the Third National Health and Nutrition Examination Survey. Diabetes Care 2004; 27:2813–8.

Goswami, R, Mishra SK, Kochupillai N. Prevalence and potential significance of vitamin D deficiency in Asian Indians. Indian J Med Res 2008; 127:229-38.

Sabherwal S, V. Bravis V, Devendra D Effect of oral vitamin D and calcium replacement on glycaemic control in South Asian patients with type 2 diabetes. Int J ClinPract 2010; 64( 8): 1084–9

Tahrani AA, Ball A, Shepherd L et al. The prevalence of vitamin D abnormalities in South Asians with type 2 diabetes mellitus in the UK. Int J ClinPract 2010;64 (3):351–5.

Taylor AV, Wise PH. Vitamin D replacement in Asians with diabetes may increase insulin resistance. Postgrad Med J. 1998; 74 (872) :365–6.

Position Statement, American Diabetic Association. Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 2009:32(S1):562-7.

Holick MF. Vitamin D Deficiency. N Engl J Med 2007; 357:266-8.

Gedik O, Akalin S. Effects of vitamin D deficiency and repletion on insulin and glucagon secretion in man. Diabetologia 1986; 29:142–5.

Allard P, Delvin EE, Paradis G et al. Distribution of fasting plasma insulin, free fatty acids, and glucose concentrations, and of homeostasis model assessment of insulin resistance in a representative sample of Quebec children and adolescents. ClinChem 2003; 49: 644-9.

Pittas AG, Lau J, Hu FB et al. The role of vitamin D and calcium in type 2 diabetes. A systematic review and metaanalysi s. J ClinEndocrinolMetab 2007; 92:2017–29.

Ashraf A, Alvarez J, Saenz K et al. Threshold for effects of vitamin D deficiency on glucose metabolism in obese female African-American adolescents: J ClinEndocrinolMetab 2009; 94(9):3200–06.

Grimnes G, Figenschau Y, Almas B et al. Vitamin D, insulin secretion, sensitivity, and lipids results from a case-control study and a randomized

controlled trial using hyperglycemicclamptechnique. Diabetes 2011; 60(11):2748–57.

Rajkumar KL, Holick MF, Heras JDL et al. 25-Hydroxyvitamin D concentrations and in vivo insulin sensitivity and beta-Cell function relative to insulin sensitivity in black and white youth.Diabetes 2012;35(3):627-33.

Mitri J, Pittas AG. Vitamin D and type 2 diabetes: a systematic review. European Journal of Clinical Nutrition 2011; 65(9): 1005-15.

Oh JY, Barrett-Connor E. Association between vitamin D receptor polymorphism and type 2 diabetes ormetabolic syndrome in community-dwelling older adults: the Rancho Bernardo Study. Metabolism 2002; 51:356 –9.

Szep Z, Guaraldi G, Shah SS, Lo Re V 3rd, Ratcliffe SJ, Orlando G, et al. Vitamin D deficiency is associated with type 2 diabetes mellitus in HIV infection. AIDS. 2011; 25 (4): 525-9.

Hidayat R, Setiati S, Soewondo P. The Association Between Vitamin D Deficiency and Type 2 Diabetes Mellitus in Elderly Patients. Acta Med Indones 2010;42(3):123-9.

de Boer IH, Tinker LF, Connelly S et al. Calcium plus vitamin D supplementation and the risk of incident diabetes in the Women’s Health Initiative. Diabetes Care 2008;31;701–7.

Liu E, Meigs JB, Pittas AG et al. Predicted 25-hydroxyvitamin D score and incident of type 2 diabetes in the Framingham Offspring Study. Am J ClinNutr 2010;91:1627–33.

Liu S, Song Y, Ford ES et al. Dietary calcium, vitamin D, and the prevalence of metabolic syndrome in middle-aged and older US women. Diabetes Care 2005; 28:2926–32.

Pittas AG, Dawson-Hughes B, Li T et al. Vitamin D and calcium intake in relation to type 2 diabetes in women. Diabetes Care 2006;9:650–6.

Von Hurst PR, Stonehouse W, Coad J. Vitamin D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D deficient - a randomised, placebo-controlled trial. Br J Nutr 2010;103, 549–55.

Jorde R, Figenschau Y. Supplementation with cholecalciferol does not improve glycaemic control in diabetic subjects with normal serum 25-hydroxyvitamin D levels. Eur J Nutr 2009;48:335-49

Downloads

Published

2012-01-02

How to Cite

Ijaz, A. ., Yousaf, S., Ali, M. Z. ., Khan, S. H. ., Sabir, S., Asif, H., Anwar, M. J. ., & Khan, N.-U.-S. . (2012). Association Of Vitamin D Status And Diabetes Mellitus. Journal of Bahria University Medical and Dental College, 2(1), 24–28. Retrieved from https://jbumdc.bahria.edu.pk/index.php/ojs/article/view/30

Issue

Vol. 2 No. 1 (2012): Volume 2 Issue 1

Section

Original Articles

License

Copyright (c) 2012 Aamir Ijaz, Shagufta Yousaf, Muhammad Zafar Ali, Sikandar Hayat Khan, Sohail Sabir, Humaira Asif, Muhammad Jaleel Anwar, Najm-Us-Saqib Khan

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Journal of Bahria University Medical & Dental College is an open access journal and is licensed under CC BY-NC 4.0. which permits unrestricted non commercial use, distribution and reproduction in any medium, provided the original work is properly cited. To view a copy of this license, visit https://creativecommons.org/licenses/by-nc/4.0