Dyslipidemia in Newly Diagnosed Diabetic Patients With or Without Micro Albuminuria

Authors

  • Naimatullah Khan
  • Javed Iqbal Khan
  • Tariq Mehmood
  • Aqeel Peter

DOI:

https://doi.org/10.51985/JBUMDC2019049

Keywords:

Dyslipidemia, Micro albuminuria, Newly diagnosed diabetic patients.

Abstract

Objective: To assess the dyslipidemia in newly diagnosed diabetic patients and compare it with or without micro albuminuria.
Study Design and Setting: Cross-sectional study at Department of Medicine, Military Hospital Rawalpindi from 01 March
2015 to 31 August 2015.
Methodology: A total of 150 patients who fulfilled the inclusion criteria were included after taking informed consent and
approval from hospital ethical committee. Blood sample was obtained from each patient and samples were sent to hospital
laboratory and reports were assessed by pathologist. Presence or absence of microalbuminuria, trigiyceridemia (200-499
mg/dl), raised LDL-C (>160 mg/dl) and decreased HDL-C (<40 mg/dl) were noted by researcher himself on a pre-designed
performa. The collected data was analyzed statistically by using SPSS version 12.Quantitative variables like age, TG, LDL
HDL levels were presented in form of mean ± S.D. Qualitative variables like gender, diabetes mellitus, micro albuminuria
and dyslipidemia were presented as frequencies and percentages. Chi-square test was applied to find association between
dyslipidemia and micro albuminuria. P value = 0.05 was considered as statistically significant.
Results: Mean ± SD of age was 47.97±7.08 years. Out of 150 patients 60% were male and 40% were female. Dyslipidemia
was found in 42% patients. Highly significant association was found between dyslipidemia and micro albuminuria, i.e.
(P=0.0001).
Conclusion: The frequency of dyslipidemia among newly diagnosed diabetic patients with micro albuminuria was
significantly higher than in subjects without micro albuminuria.

References

Herath H, Weerasinghe N, Dias H, Weerarathna T. Knowledge,

attitude and practice related to diabetes mellitus among the

general public in Galle district in Southern Sri Lanka: a pilot

study. BMC Public Health. 2017;17(1).

Sami W, Ansari T, Butt NS, Ab Hamid MR. Effect of diet on

type 2 diabetes mellitus: A review. International journal of

health sciences. 2017;11(2):65.

Previti E, Salinari S, Bertuzzi A, Capristo E, Bornstein S,

Mingrone G. Glycemic control after metabolic surgery: a

Granger causality and graph analysis. American Journal of

Physiology - Endocrinology And Metabolism. 2017;:ajpendo.

2017.

World Health Organization. Global report on diabetes [Internet].

Geneva: World Health Organization; 2016. Available from:

http://www.who.int/diabetes/global-report/en/

Akhtar S, Khan Z, Rafiq M, Khan A. Prevalence of Type II

diabetes in District Dir Lower in Pakistan. Pakistan Journal of

Medical Sciences. 2016;32(3).

Abdel-Gayoum AG. The effect of glycemic control in type 2

diabetic patients with diabetes-related dyslipidemia. Saudi

Med J. 2004;25:207-11.

Prasad R, Groop L. Genetics of Type 2 Diabetes—Pitfalls and

Possibilities. Genes. 2015;6(4):87-123.

Cantley J, Ashcroft F. Q&A: insulin secretion and type 2

diabetes: why do â-cells fail?. BMC Biology. 2015;13(1).

Afsar B, Elsurer R. The independent relationship between

creatinine clearance, micro albuminuria and circadian blood

pressure levels in newly diagnosed essential hypertensive and

type 2 diabetic patients. J Diabetes Complications. 2012;26:531-

Adar T, Lysy J. Pseudodyslipidemia: are we over-treating

dyslipidemia in diabetic patients with undiagnosed

gastroparesis? Endocrine. 2014;45:26-7.

Agaba EI, Agaba PA, Puepet FH. Prevalence of micro

albuminuria in newly diagnosed type 2 diabetic patients in Jos

Nigeria. Afr J Med Med Sci. 2004;33:19-22.

Chen SC, Tseng CH. Dyslipidemia, kidney disease, and

cardiovascular disease in diabetic patients. Rev Diabet Stud.

;10:88-100.

Chen SC, Tseng CH. Dyslipidemia, kidney disease, and

cardiovascular disease in diabetic patients. The review of

diabetic studies: RDS. 2013;10(2-3):88.

Harris MI, Eastman RC. Early detection of undiagnosed diabetes

mellitus: a US perspective. Diabetes/metabolism research and

reviews. 2000;16:230-6.

Huang JW, Lien YC, Yang CY, Liu KL, Wu CF, Yen CJ, et

al. Osteoprotegerin, inflammation and dyslipidemia are

associated with abdominal aortic calcification in non-diabetic

patients on peritoneal dialysis. NutrMetabCardiovasc Dis.

;24:236-42.

Jisieike-Onuigbo NN, Unuigbe EI, Kalu OA, Oguejiofor CO,

Onuigbo PC. Prevalence of dyslipidemia among adult diabetic

patients with overt diabetic nephropathy in Anambra state

south-east Nigeria. Niger J ClinPract. 2011;14:171-5.

PascualFuster V, Ruiz Olivar E, Pinto Sala X. [Patient's care

and management of dyslipidemia in type 2 diabetic patients

in the clinical practice in Spain: The LIPEDIA study].

ClinInvestigArterioscler. 2015;27:45-56.

Goff DC, Bertoni AG, Kramer H, Bonds D, Blumenthal RS,

Tsai MY, et al. Dyslipidemia prevalence, treatment, and control

in the multi-ethnic study of atherosclerosis (MESA) gender,

ethnicity, and coronary artery calcium. Circulation.

;113:647-56.

Xu Y, Bao Q, He B, Pan Y, Zhang R, Mao X, et al. Association

of angiotensin I converting enzyme, angiotensin II type 1

receptor and angiotensin I converting enzyme 2 gene

polymorphisms with the dyslipidemia in type 2 diabetic

patients of Chinese Han origin. J Endocrinol Invest.

;35:378-83.

Yadav D, Mishra M, Tiwari A, Bisen PS, Goswamy HM,

Prasad GB. Prevalence of dyslipidemia and hypertension in

Indian type 2 diabetic patients with metabolic syndrome and

its clinical significance. Osong Public Health Res Perspect.

;5:169-75.

Haffner SM. American diabetes association. Dyslipidemia

management in adults with diabetes. 2004.

Bays HE, Chapman R, Grandy S. The relationship of body

mass index to diabetes mellitus, hypertension and

dyslipidaemia: comparison of data from two national surveys.

International journal of clinical practice. 2007;61:737-47.

Zimmet PZ, Alberti G. The Metabolic Syndrome: Perhaps an

Etiologic Mystery but Far From a Myth—Where Does the

International Diabetes Federation Stand? Medscape Diabetes

& Endocrinology. 2005;8.

Ormazabal V, Nair S, Elfeky O, Aguayo C, Salomon C, Zuñiga

FA. Association between insulin resistance and the

development of cardiovascular disease. Cardiovascular

diabetology. 2018;17(1):122.

Nielsen JB, Leppin A, e Gyrd-Hansen D, Jarbøl DE,

Søndergaard J, Larsen PV. Barriers to lifestyle changes for

prevention of cardiovascular disease–a survey among 40–60-

year old Danes. BMC cardiovascular disorders.

;17(1):245.

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Published

2021-07-29

How to Cite

Khan, N. ., Khan, J. I. ., Mehmood, T. ., & Peter, A. . (2021). Dyslipidemia in Newly Diagnosed Diabetic Patients With or Without Micro Albuminuria. Journal of Bahria University Medical and Dental College, 10(2), 129–132. https://doi.org/10.51985/JBUMDC2019049

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