Pre-Pregnancy Obesity: A friend or foe for Vitamin D
DOI:
https://doi.org/10.51985/JBUMDC2019136Abstract
Vitamin D and its active metabolite 1,25 - dihydrooxyvitamin
D (1,25(OH) 2D) has been generally recognized as repertoire
of many classical (calcium balance and bone metabolism)
and non-classical effects (non-calcium actions) such as
promotion of insulin secretion and its action,
immunomodulation. Absorption of calcium and phosphorus
depends on sufficient vitamin D levels. Its low level leads
to demineralization of bone both in children and adults.
Vitamin D has also a significant role and has potential to
influence many factors in the developing fetus. Newborns
are at high risk of developing hypocalcaemic tetany as a
consequence of maternal deficiency of vitamin D.
References
Al-Musharaf S, Fouda M, Turkestani I, Al-Ajlan A, Sabico S, Alnaami A, Wani K, Hussain S, Alraqebah B, Al-Serehi A, Alshingetti N. Vitamin D deficiency prevalence and predictors in early pregnancy among Arab women. Nutrients. 2018;10(4):489.
Bodnar LM, Catov JM, Roberts JM, Simhan HN. Prepregnancy obesity predicts poor vitamin D status in mothers and their neonates. The Journal of nutrition. 2007;137(11):2437-42.
Hogan MC, Foreman KJ, Naghavi M. Maternal mortality for 181 countries, 1980-2008: a systematic analysis of progress towards millennium development goal 5. Lancet 2010; 375:1609-23
Wei SQ, Qi HP, Luo ZC. Maternal vitamin D status and adverse pregnancy outcomes: a systematic review and meta- analysis. J Matern Fetal Neonatal Med 2013; 26:889-99.
Mulligan ML, Felton SK, Riek AE. Implications of vitamin D deficiency in pregnancy and lactation. American J Obstet Gynecol 2010; 202:e421-9.
Sung CC, Liao MT, Lu KC, Wu CC. Role of vitamin D in insulin resistance. BioMed Research International. 2012 doi: 10.1155/2012/634195
Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF. Decreased bioavailability of vitamin D in obesity. The American journal of clinical nutrition. 2000;72(3):690-3.
Villamor E, Cnattingius S. Interpregnancy weight change and risk of adverse pregnancy outcomes: a population-based study. The Lancet. 2006;368(9542):1164-70.
Sebire NJ, Jolly M, Harris JP, Wadsworth J, Joffe M, Beard RW, Regan L, Robinson S. Maternal obesity and pregnancy outcome: a study of 287 213 pregnancies in London. International journal of obesity. 2001;25(8):1175.
Parikh SJ, Edelman M, Uwaifo GI, Freedman RJ, Semega- Janneh M, Reynolds J, Yanovski JA. The relationship between obesity and serum 1, 25-dihydroxy vitamin D concentrations in healthy adults. The Journal of Clinical Endocrinology & Metabolism. 2004;89(3):1196-9.
Holick MF. Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis. The American journal of clinical nutrition. 2004 ;79(3):362-71.
Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF. Decreased bioavailability of vitamin D in obesity. The American journal of clinical nutrition. 2000 ;72(3):690-3.
Cnattingius S, Villamor E, Lagerros YT, Wikström AK, Granath F. High birth weight and obesity—a vicious circle across generations. International journal of obesity. 2012;36(10):1320.
Morley R, Carlin JB, Pasco JA, Wark JD. Maternal 25- hydroxyvitamin D and parathyroid hormone concentrations and offspring birth size. The Journal of Clinical Endocrinology & Metabolism. 2006 ;91(3):906-12.
Kim SY, Dietz PM, England L, Morrow B, Callaghan WM. Trends in pre-pregnancy obesity in nine states, 1993–2003. Obesity. 2007;15(4):986-93
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2020 Fareeha Shahid, Farhan Muhammad Qureshi
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Journal of Bahria University Medical & Dental College is an open access journal and is licensed under CC BY-NC 4.0. which permits unrestricted non commercial use, distribution and reproduction in any medium, provided the original work is properly cited. To view a copy of this license, visit https://creativecommons.org/licenses/by-nc/4.0 
