Comparison Of Vitamin B12 Level Among Vegetarian And Non Vegetarian Apparently Healthy Individuals In District Tharparkar
Keywords:
Vitamin B12, Vegetarian, non-vegetarian.Abstract
Objective: Subjects adopting a vegetarian diet are liable to vitamin B12 deficiency. The current work was undertaken to investigate vitamin B12 status in apparently healthy vegetarians in Mithi, district Tharparkar, Sindh.
Subjects and methods: This cross sectional study was conducted in the department of Biochemistry, BMSI, JPMC Karachi and blood samples were collected from Mithi district Tharparkar, Sindh, during the period of Febuary 2012 to June 2012. One hundred vegetarian (74 males and 26 females) and one hundred non- vegetarians (72 males and 28 females), age ranging from 20-40 years were enrolled for this study. Hemogloblin concentration, means corpuscular volume and serum vitamin B12 levels were measured, using conventional methods.
Results: Mean serum vitamin B12 level and mean hemoglobin concentration were significantly lower (p<0.001) while mean corpuscular volume (MCV) was significantly higher (p<0.001) in vegetarian as compared to non-vegetarian. In vegetarian group 51(51%) subjects had vitamin B12 level less than cut off value (200 pg/ml), in this group, 38 out of 74 (51.3%) and 13 out of 26 (50%) were males and females respectively. In non vegetarian group 21(21%) subjects had vitamin B12 deficiency and 09 out of 72 (12.5%) and 12 out of 28(43%) were males and females respectively.
Conclusion: Vegetarians seems to be more prone to develop vitamin B12 deficiency so they should take vitamin B12 supplement and/or B-12 fortified products to avoid its deficiency consequences
References
Watanabe F. Vitamin B12 sources and bioavailability. Exp Biol Med. 2007;232:1266-74.
Herbert V. Vitamin B-12: plant sources, requirements, and assay. Am J Clin Nutr. 1988;48:852- 8.
Craig WJ, Mangels AR. American Dietetic Association. Position of the American Dietetic Association: vegetarian diets. J Am Diet Assoc 2009;109:1266-82
Mądry E, Lisowska A, Chabasińska M, et al. Effect of lacto-ovo-vegetarian diet on serum vitamin B12 concentrations–five-year prospective study. Acta Sci Pol Technol Aliment 2009;8 (4):71-6.
Herrmann W, Schorr H, Obeid R, et al. Vitamin B12 status, particularly holotranscobalamin II and methylmalonic acid concentrations, and hyperhomocysteinemia in vegetarians. Am J Clin Nutr 2003;78:131-6.
Robrt C, Brown D. Vitamin B12 deficiency. Am Fam Phy 2003; 67 :979-86.
Reynolds E. Vitamin B12, folic acid, and the nervous system. Lancet Neurol 2006;5:949-60.
Kumar J, Garg G, Sundaramoorthy E, et al. Vitamin B12 deficiency is associated with coronary artery disease in an Indian population. Clin Chem Lab Med 2009;47(3):334-8
Metz J. A high prevalence of biochemical evidence of vitamin B12 or folate deficiency does not translate into a comparable prevalence of anemia. Food Nutr Bull. 2008;29:7485.
Haddad EH, Tanzman JS. What do vegeterians in the United States eat. Am J Clin Nutr 2003; 78(Suppl):626S-32S.
Dwyer JT. Nutritional consequences of vegetarianism. Annu Rev Nutr 1991;11:61–91.
Refsum H, Yajnik CS, Gadkari M, et al. Hyperhomocysteinemia and elevated methylmalonic acid indicate a high prevalence of cobalamin deficiency in Asian Indians. Am J Clin Nutr 2001;74:233–41.
Kumar S. Recurrent seizures: An unusual manifestation of vitamin B12 deficiency. Neurol India 2004;52:122-3.
Arora S, Singh B, Gupta VK et al. Burden of vitamin b12 deficiency in urban population in Delhi, India: A hospital based study. Int J Pharma Bio Sci 2011;2(1):521-8.
Reddy S, Sanders T. Haematological studies on premenopausal Indian and Caucasian vegetarians compared with Caucasian omnivores. British Journal of Nutrition 1990;64: 331-8
Gilsing AM, Crowe FL, Lloyd-Wright Z, et al. Serum concentrations of vitamin B12 and folate in British male omnivores, vegetarians, and vegans: results from a crosssectional analysis of the EPIC-Oxford cohort study. Eur J Clin Nutr 2010 ; 64(9): 933–9.
Majchrzak D, Singer I, Manner M, et al. B-Vitamin Status and Concentrations of Homocysteine in Austrian Omnivores, Vegetarians and Vegans. Ann Nutr Metab 2006;50:485.
Haddad EH, Berk LS, Kettering JD, et al. Dietary intake and biochemical, hematologic, and immune status of vegans compared with nonvegetarians. Am J Clin Nutr 1999;70:586– 93S.
Herrmann W, Schorr H, Purschwitz K, et al. Total homocysteine, vitamin B12, and total antioxidant status in vegetarians. Clin Chem 2001;47:1094–101.
Obeid R, Geisel J, Schorr H, et al. The impact of vegetarianism on some haematological parameters. Eur J Haematol 2002: 69: 275–9.
McKenzie SB. Textbook of Hematology, Philadelphia: Lee & Febiger, 1988. p. 108.
Barghouti FF, Yonus NA, Halaseh LJ, et al. High frequency of low serum levels of vitamin B12 among patients attending Jordan University Hospital. East Med Heath J 2009;15:853-60.
Herrmann W, Geisel J. Vegetarian lifestyle and monitoring of vitamin B-12 status. Clin Chim Acta 2002;326(1-2):47-59.
Gupta AK, Damiji A, Uppaluri A. Vitamin B12 deficiency Canadian family physician 2004;50:743-6
Loikas S, Koskinen P, Irjala K, et al. Vitamin B12 deficiency in the aged: a population-based study. Age and Ageing 2007;36(2):177-83.
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