Correlation Of Hematocrit And Hemoglobin With Obesity, Serum Lipids And Aldosterone In Newly Diagnosed Hypertensive Patients

Authors

  • Sadiqa Syed
  • Shazia Shakoor
  • Masood A Qureshi

Keywords:

hypertension, hematocrit, hemoglobin, triglyceride, aldosterone

Abstract

To determine the relationship of obesity indicators with certain hemodynamic and metabolic cardiovascular risk factors, at the initial diagnosis
of hypertension in a random population, in search of a treatable cause
Methods: A case control study was conducted on 201 subjects aged between 25-60 years, diagnosed primarily as prehypertensive or hypertensive stage I
and II , selected from five general practitioners clinics in Karachi. Estimated of hematocrit, hemoglobin, triglycerides, low density lipoproteins, serum
potassium level and aldosterone was done. Their body mass index and waist hip ratio were calculated by measuring body weight, height, waist and hip
circumference. The values obtained were compared with 75 controls with normal blood pressure.
The mean and standard deviation were computed. Analysis was done by SPSS version 15.LSD test was applied to compare pair-wise group. Pearson’s
correlation was applied to find out association of different variables with one another, within each of the four groups
Results: The overall percentages of overweight and obese subjects were higher in all four groups. The mean hematocrit and hemoglobin levels were
highest in HTN stage –I (44.7±5.25 and15.4±2.20 respectively). Hemoglobin was strongly correlated to systolic blood pressure and waist hip ratio in both
hypertension stages-I and II (p<0.01). Whereas hematocrit was positively correlated to body mass index, triglycerides, serum potassium and aldosterone
levels in both stages of hypertension (p<0.01)
Conclusion: High hematocrit, hemoglobin, triglyceride levels, visceral fat accumulation and aldosterone secretion are important and independent risk
factors for hypertension.

References

Brown DW, Giles WH, Croft JB. Hematocrit and the risk of common heart disease mortality, Am J Hypertens, 2001; 142(4) : 657-63

Facchini FS, Carantoni M, Jeppesen J, et al. Hematocrit and hemoglobin are independently related to insulin resistance and compensatory hyperinsulinemia in healthy non-obese men and women. Metabolism, 1998; 47(7) : 831-5

Narayan P, Papademetriou V, Watchtell K, et al. Association of hemoglobin delivery with left ventricular structure and function in hypertensive patients. Hypertension, 2006: 47 : 868-73

Braekkan S, Mathiesen EB, Njolstad I, et al. Hematocrit and risk of venous thromboembolism in a general population. The Tromas Study. Hematologica, 2010; 95(2) : 270-5

Cecchi E, Marcucci R, Poli D, et al. Hyperviscosity as a possible risk factor for cerebral ischemia complications in atrial fibrillation patients. Am J Cardiol, 2006; 97(12): 1745-8

Hingorani AD,. Endothelial nitric oxide synthase polymorphism and hypertension. Curr Hypertens Rep, 2003; 5 : 19-25

Natali A, Toschi E, Baldeweg S, et al. Hematocrit, type 2 diabetes and endothelium dependent vasodilation of resistance vessesl. Eur Heart J, 2005; 26(5) : 464-71

Chonchol M, Nielson C. hemoglobin levels and coronary artey disease. Am Heart J, 2008; 155(8) : 494-8

Lin JD, Chiou WK, Chang HY, et al. Association of hematological factors with components of metabolic syndrome in older and younger adults. Aging Clin Exp res, 2006; 18(6) : 477-84

Zhu W, Li M, Huang X, et al. Association of hyperviscosity and subclinical atherosclerosis in obese children. Eur j Pediatr, 2005; 164(10) : 1725-9

Crowley JP, Metzger J, Assaf A, et al. Low density lipoprotein cholesteroland whole blood viscosity. Ann Clin Lab Sci, 1994; 24(6): 533-41

Rosenson RS, Shott s, Tangney CC. Triglycerides and blood viscosity. Atherosclerosis, 2002; 161(2) : 433-9

Kharb S. Association between rheology and lipoproteins in menopausal women. JKScience, 2008; 10(1) ;9-10

Tamariz LJ, young JH, Pankow JS, et al. Hematocrit as risk factor for type 2 diabetes mellitus. Am j Epidemiol, 2008; 168(10) : 1153-60

Kelly DE, Thaeten FL, Troost F, et al. Subdivisions of subcutaneous abdominal adipose tissue and insulin resistance. Am j Physiol Endocrinol Metab, 2000; 278 : 941-8

Goodfriend TL, Ball DL, Gardner HW. Prostaglandins, leukotriens and essential fatty acids. 2002; 67 :163-7

Vlahakos DV, Kosmas EN, Pimopoulou I, et al. Association between activation of rennin

angiotensin system and secondary erythropoiesis in patients with chronic obstructive pulmonary disease. Am J Med, 1999; 106(2) : 158-64

Chobanian AV, Bakris GL, Black HR, et al. The 7th report of the Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure. JAMA, 2003; 289(19): 2562-74

NCEP. National Cholesterol Education Program. Expert panel on detection, Evaluation and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Final report. Circulation, 2002; 106(25) : 3143-421

Syed S, Qureshi MA. Anthropometric and metabolic indicators in hypertensive patients. JCPSP, 2009; 19(7) : 421-7

Pakistan Hypertension League (1998). First Report on National task Force (NTF-1) on hypertension, 1998

Devereaux RB, Case DB, Alderman MH, et al. Possible role of increased blood viscosity in the hemodynamics of systemic hypertension. Am J Cardiol, 2000; 85: 1265-8

Dalton M, Camerson AJ, Zimmet PJ et al. waist circumference, waist hip ratio and body mass index and their correlation with cardiovascular disease risk factors in Australian adults. J Int Med, 2003; 254(6) : 555-63

Jafar TH, Chatruvedi N, Pappas G. Prevalence of overweight and obesity and their association with hypertension and diabetes mellitus in an Indo-Asian population. CMAJ, 2006; 175(9) :1071-7

Irace C, Carallo C, Scavelli F, et al. Lack of association between systolic blood pressure and blood viscosity in normotensive healthy subjects. Clin Hematol Microcirc, 2012 [epub ahead of print]

Cirillo M, Laurenzi M, Trevisan M. Hematocrit, blood pressure and hypertension; The Gubbio Population Study. Hypertension, 1992; 20(3) : 319-26

Paknahad Z, Mahboob S, Omidvar N, et al. Body mass index and its relationship with hematological indices in Iranian women. Pak J Nutr, 2008; 7(2) : 377-80

Choi KM, Lee J, Kim YH, et al. Relation between insulin resistance and hematological parameters in elderly Korean-Southwest Seoul (SWS) Study. Diabetes Research and Clinical practice, 2003; 60(3) : 205-12

Nakanishi N, Yoshida H, Okamoto M, et al. Hematocrit and risk for hypertension in middle-aged Japanese male office workers. Industrial Health, 2001; 39: 17-20

Diamond R, Singh B. Brief overview of maternal triglycerides as a risk factor for preeclampsia. BJOG, 2006; 113(4) : 379-86

Harano Y, Suzuki M, Koyoma Y, et al. Multifactorial insulin resistance and clinical impact in hypertension and cardiovascular diseases. Journal of Diabetes and its implications, 2002; 16(1) : 19-23

Andronico G, et al. Insulin, rennin aldosterone system and blood pressure in obese people. Int j Obes Relat metab Disord,2001; 25(2) : 239-4

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Published

2012-01-02

How to Cite

Syed, S. ., Shakoor, S. ., & A Qureshi, M. . (2012). Correlation Of Hematocrit And Hemoglobin With Obesity, Serum Lipids And Aldosterone In Newly Diagnosed Hypertensive Patients. Journal of Bahria University Medical and Dental College, 2(1), 8–12. Retrieved from https://jbumdc.bahria.edu.pk/index.php/ojs/article/view/27

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