Prevalence of Hypertriglyceridemia and Risk Factors of Ischemic Versus Hemorrhagic Stroke
Keywords:
Hemorrhagic stroke, Hypertriglyceridemia, Ischemic strokeAbstract
Objective: To find the prevalence of hypertriglyceridemia in ischemic and hemorrhagic strokes and to assess the risk factors
associated with them.
Methodology: This cross-sectional study was conducted in Medical OPD/ Emergency, PAF Hospital Mushaf, Sargodha over
a period of six months from Nov-2010 to May-2011. All patients of either gender diagnosed as having stroke, with hyper dense
or hypo dense area on CT scan brain and of age more than 30 years were included in the study. Patients on anti-hyperlipidemic
drugs, with previous history of stroke, having blood disorders, like hemophilia and idiopathic thrombocytopenic purpura and,
on warfarin therapy were excluded from the study.
Results: 203 patients were enrolled in the study. Out of these 203 patients 138(68%) were males, 65 (32%) were females.
127(62.6%) stroke patients had hypertriglyceridemia. In multivariate analysis, hypertriglyceridemia was found to be the only
risk factor associated with ischemic stroke adjusting for all the other variables. It was found that patients with hypertriglyceridemia
had 3.24 times higher odds of having ischemic stroke (P-value=0.017).
Conclusion: Hypertriglyceridemia was found in majority of the patients with stroke. Furthermore, it was found to be an
independent risk factor of ischemic stroke.
References
Bonaventure A, Kurth T, Pico F, Barberger-Gateau P, Ritchie K, Stapf C et al. Triglycerides and risk of hemorrhagic stroke vs. ischemic vascular events: The Three-City Study. Atherosclerosis 2010;210(1):243-8
Zweifler RM. Management of acute stroke. (Featured CME Topic: Stroke). Southern medical journal 2003;96 (4):380-6
Khan NI, Naz L, Mushtaq S, Rukh L, Ali S, Hussain Z. Ischaemic stroke: prevalence of modifiable risk factors in male and female patients in Pakistan. Pak J Pharm Sci 2009;22:62-7
Truelsen T, Begg S, Mathers C. The global burden of cerebrovascular disease. Geneva: World Health Organ- isation 2000-doi: 103402/fnr.v59.27486
Aljefree N, Ahmed F. Prevalence of cardiovascular disease and associated risk factors among adult population in the Gulf region: a systematic review. Advances in Public Health 2015;2015, Article ID 235101,23 pages
Syed NA, Khealani BA, Ali S, Hasan A, Akhtar N, Brohi H, et al. Ischemic stroke subtypes in Pakistan: the Aga Khan University Stroke Data Bank. JPMA The Journal of the Pakistan Medical Association 2003;53(12):584- 8
Vohra EA, Ahmed WU, Ali M. Aetiology and prognostic factors of patients admitted for stroke. The Journal of the Pakistan Medical Association 2000;50(7):234- 6
Jafar TH. Blood pressure, diabetes, and increased dietary salt associated with stroke--results from a community- based study in Pakistan. J Hum Hypertens 2006;20(1): 83-5
Bashir K, Langhorne P, Lees KR, MacAlpine C, Muir K, Murray S, et al. Epidemiological aspects of referral to TIA clinics in Glasgow. Scott Med J 2007; 52:4-8
Iqbal F, Hussain S, Hassan M. Hypertension, diabetes mellitus and hypercholesterolaemia as risk factors for stroke. Pak J Med Res 2003; 42:17-22
Mahmood A, Sharif MA, Khan MN, Ali UZ. Comparison of serum lipid profile in ischaemic and haemorrhagic stroke. Journal of the College of Physicians and Surgeons-
-Pakistan 2010;20(5):317-20
Zhang J, Wang Y, Wang GN, Sun H, Sun T, Shi JQ, et al. Clinical factors in patients with ischemic versus hemorrhagic stroke in East China. World J Emerg Med. 2011;2(1):18-23
Almani SA, Shaikh M, Shaikh MA, Shaikh K, Rahopoto Q, Baloch GH, et al. Stroke: frequency of risk factors in patients admitted at Liaquat University Hospital Hyderabad/Jamshoro. J Liaquat Uni Med Health Sci. 2008;4:151-6
Tanne D, Koren-Morag N, Graff E, Goldbourt U. Blood lipids and first-ever ischemic stroke/transient ischemic attack in the Bezafibrate Infarction Prevention (BIP) Registry: high triglycerides constitute an independent risk factor. Circulation 2001;104(24):2892-7
Varbo A, Nordestgaard BG, Tybjaerq-Hansen A, Schnohr P, Jensen GB, Benn M. Nonfasting triglycerides, cholesterol, and ischemic stroke in the general population. Ann Neurol. 2011;69(4):628-34
Marijana L, Vida D, Zlatko T, Vanja B-K. Hypertrigly ceridemia as a possible independent risk factor for stroke. Acta Clinica Croatica. 2013;52(4.):458-62
Antonios N, Angiolillo DJ, Silliman S. Hypertrigly- ceridemia and ischemic stroke. European neurology 2008;60(6):269-78
Park J-H, Kwon H-M. Association between metabolic syndrome and previous ischemic lesions in patients with intracranial atherosclerotic stroke. Clin Neurol Neurosurg. 2008;110(3):215-21
Lindenstrom E, Boysen G, Nyboe J. Influence of total cholesterol, high density lipoprotein cholesterol, and triglycerides on risk of cerebrovascular disease: the Copenhagen City Heart Study. BMJ 1994;309(6946):11- 5
Kayhan C, Daffertshofer M, Mielke O, Hennerici M, Schwarz S. Comparison between German and Turkish descent in ischemic stroke. Risk factors, initial findings, rehabilitative therapy, and social consequences. Der Nervenarzt. 2007;78(2):188-92
Hocker S, Morales-Vidal S, Schneck MJ. Management of arterial blood pressure in acute ischemic and hemorrhagic stroke. Neurol Clin. 2010;28(4):863-86
Rodgers H, Greenaway J, Davies T, Wood R, Steen N, Thomson R. Risk factors for first-ever stroke in older people in the north East of England: a population-based study. Stroke 2004;35(1):7-11
Green D, Ropper A, Kronmal R, Psaty B, Burke G. Serum potassium level and dietary potassium intake as risk factors for stroke. Neurology 2002;59(3):314- 20
Haheim LL, Holme I, Hjermann I, Leren P. Smoking habits and risk of fatal stroke: 18 years follow up of the Oslo study. J Epidemiol Community Health 1996;50(6): 621-24
Abbot RD, Curb JD, Rodriguez BL, Masaki KH, Popper JS, Ross GW et al. Age-related changes in risk factor effects on the incidence of thromboembolic and hemorrhagic stroke. J clin Epidemiol 2003; 56(5): 479- 86
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Copyright (c) 2017 Ayaz Ahmed, Muhammad Fahad Waseem, Wajeeha Ahad, Muhammad Tahir, Naveed Aslam
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