Herbal Treatment of Diabetes
Keywords:
Plants, hypoglycemia, antidiabetic mechanism, biologically active compoundsAbstract
Diabetes has become one of the most challenging health problems of the 21st century, with increasing prevalence throughout
the world. Drugs recently used for the treatment of diabetes have several adverse effects. There is an immense need to explore
plant resources to develop a better oral hypoglycemic agent.More than 400 plants are found to have hypoglycemic effect like
Acacia Arabia, Aeglemarmelos, Alium cepa, Alium sativum ,Azadirachta indica,Caesalpinia bonducella, Coccinia indica,
Eugenia jambolana,Mangifera indica, Momordica charantia and Ocimum sanctum. These are found to act by various mechanisms
to produce antidiabetic effect. Moreover, various biologically active compounds with hypoglycemic effect are identified from
these plants. including alkaloids, flavonoids, glycosides and polysaccharides. This commentary presents an overview of
antidiabetic plants and their suggested hypoglycemic mechanisms.
References
Bailey C J, Day C.Traditional plant medicines as treatments
for diabetes.Diabetes Care 1989;12:553-64.
Villegas R, Sbu Xo,Gao YT,Yang G, Elasy T,Li H,
Zhang W etal.Vegetables but not fruit consumption reduces
the risk of type-2 diabetes in Chinese woman.J
Nutr 2008; 138(3): 574-58.
Neroman BD,O Sala, and Wilcox BP.Conference promotes
study of echohydrops of Semi-arid Landscapes.
EOS Trans AGO 2003;84:13-7.
Farnsworth, NR., Morris RW. Higher plants: the sleeping
giant of drug development. Am. J. Pharm 1976;46.
Pulok KM, Kuntal M, Kakali M, Peter JH. Leads from
Indian medicinal plants with hypoglycemic potentials.
J Ethnopharmacol 2006;106:1-28.
Waqar MA, Mahmood Y. Yasir Mahmood. Antiplatelet,
antihypercholesterolemic and antioxidant activities of
Brassica olerace in high fat diet provided Rats.World
Applied Sciences Journal 2010;8(1):107-12.
Miura T, Itohc I, wamoto N,Aato M, Kawar M, Park
SR et al. Hypoglycemic activity of the fruit of the
Momordia charantia in type-2 diabetic mice.J. Nutrition
vitaminol 2001;47:340-4.
Kim JS, Ju BB,Choi CW,Kim SC.Hypoglycemic and
antihyperlipidemic effect of four Korean medicinal
plants in alloxan induced diabetic rats. Am J Biochem
Biotech 2006;2:154-60.
Heidari R, Devonshire AL, Campbell BE, Dorrian SJ,
Oakeshott UG, Russel RJ. Hydrolysis of pyrethroid by
carboxyles-terases from Luciliacuprine and drosophila
melanogaster with active sites modified by its in vitro
mutagenesis.Inset BiochemMol biology 2005;35:597-
Wadood N, Shah S A. Effects of Acacia arabica and
Carallumaedulis on blood glucose levels on normal and
alloxan diabetic rabbits. J. Pakistan Med Assoc1989;39
:208-12
Karunnanayake E H, Welihinda J, Sirimanne SR,
Sinnadorai G. Oral hypoglycemic activity of some
medicinal plants of Sri Lanka. J. Ethnopharmacol1984;11:
-31.
Ramos-n-Ramos R, Flores-Saenz JL, Alaricon-Aguilar
FJ. Antihypertensive and Hypoglycemic effect of some
edible plants. J. Ethnopharmacol Wa1995;48:25-32.
Augusti KT, Shella CG.Antiperoxide effect of S-allyl
cysteine sulfoxide, an insulin secretagogue in diabetic
rats. Experientia1996;52:115-20.
Chattopadhyay RR, Chattopadhyay RN, Nandy AK,
Poddar G, Maitra SK. The effect of fresh leaves of
Azadiracta indica on glucose uptake and glycogen content
in the isolated rat hemidiaphragm. Bull. Calcutta. Sch.
Trop. Med 1987;35:8-12.
Sharma SR, Dwivedi SK, Swarup D. Hypoglycemic,
antihyperglycemic and hypolipidemic activities of
Caesalpinia bonducella seeds in rats. J. Ethnopharmacol
;58:39-44.
Kamble SM, Kamlakar PL, Vaidya S, Bambole VD.
Influence of Coccinia indica on certain enzymes in
glycolytic and lipolytic pathway in human diabetes.
Indian J. Med. Sci1998;52:143-146.
Acherekar S, Kaklij GS, Kelkar SM. Hypoglycemic
activity of Eugenia jambolana and ficusbengalensis:
mechanism of action In vivo. 1991;5:143-7.
Aderibigbe AO, Emudianughe TS, Lawal BA. Antihyperglycemic
effect of Mangifera indica in rat. Phytother
Res1999;13:504-7.
Khanna P, Jain SC, Panagariya A, Dixit VP. Hypoglycemic
activity of polypeptide- p from a plant source.
J. Nat. Prod 1981;44:648-55.
Vats V,Yadav SP. Grover, Ethanolic extract of Ocimum
sanctum leaves partially attenuates streptozotocin induced
alteration in glycogen content and carbohydrate metabolism
in rats. J. Ethnopharmacol2004;90:155-60.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2016 Tahira Zamir, Talea Hoor
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Journal of Bahria University Medical & Dental College is an open access journal and is licensed under CC BY-NC 4.0. which permits unrestricted non commercial use, distribution and reproduction in any medium, provided the original work is properly cited. To view a copy of this license, visit https://creativecommons.org/licenses/by-nc/4.0 
