Unravelling the Influence of Demographic and Lifestyle Factors on Monocyte Chemoattractant Protein-1 in Diabetic Retinopathy Patients

Authors

  • Shabeer Ahmed
  • Hammad Raziq
  • Noman Sadiq
  • Sana Soomro
  • Rubina Amjad
  • Wazir Ahmed Baloch

DOI:

https://doi.org/10.51985/JBUMDC2023179

Keywords:

Diabetic Retinopathy, Exercise, Gender, Monocyte Chemoattractant Protein-1, Smoking.

Abstract

Objectives: To determine the association of Monocyte chemoattractant protein-1 (MCP-1) level with Age, blood glucose
level, Exercise, Gender and Smoking in diabetic retinopathy patients.
Study Design and settings: A case-control study was carried in the physiology department at the Jinnah Postgraduate
Medical Centre in Karachi From April 2019 to October 2020.
Methodology: One hundred people were divided into four groups which were; Group D (n=25) were healthy normal
individuals; Group C (n=25) diabetic patient's with moderate retinopathy; Group B (n=25) diabetic patient's with mild
retinopathy while Group A (n=25) diabetic patients with no retinopathy. Every participant was checked for blood sugar
level, retinoscopy through slit lamp examination and serum MCP-1 level. The association was made between diabetic
retinopathy, MCP-1 protein levels, age, gender, smoking and exercise.
Results: MCP-1 levels are significantly greater in diabetic males with moderate retinopathy compared to diabetic females
with moderate retinopathy (p-value 0.042). Similarly, smoking is associated with the elevation of MCP-1 levels in diabetic
patients with moderate retinopathy (p-value 0.05). Exercise has no significant effect on MCP-1 levels in all groups. An
increase in age, HbA1C, fasting and random blood glucose levels were significantly correlated with MCP-1 levels ( pvalue 0.000)
Conclusion: It is concluded from the study that an advance in age and an increase in blood glucose level are associated
with an increased level of MCP-1 protein. Moreover, Male gender and smoking are also associated with enhanced MCP-
1 levels in diabetic patients with moderate retinopathy.

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Published

2023-07-13

How to Cite

Ahmed, S. ., Raziq, H. ., Sadiq, N. ., Soomro, S. ., Amjad, R. ., & Baloch, W. A. . (2023). Unravelling the Influence of Demographic and Lifestyle Factors on Monocyte Chemoattractant Protein-1 in Diabetic Retinopathy Patients. Journal of Bahria University Medical and Dental College, 13(03), 157–161. https://doi.org/10.51985/JBUMDC2023179

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