Association of Resistin with Components of Metabolic Syndrome in Our Local Population

Authors

  • Mozaffer Rahim Hingorjo
  • Muhammad Noman Rashid
  • Naila Parveen
  • Lubna Riaz
  • Riaz Ahmed Shahid
  • Zainab Hasan

DOI:

https://doi.org/10.51985/JBUMDC2021131

Keywords:

Diabetes Mellitus; Metabolic syndrome; Resistin

Abstract

Objective: To investigate the association of resistin with components of metabolic syndrome (MetS) in our local population.
Study design & setting: Case-control study, Medical OPD; Lyari General Hospital Karachi (from 15th July 2020 till 15th
December 2020).
Methodology: A total of 164 subjects (83 cases & 81 controls) between the age ranges of 35-65 years were selected.
Subjects with metabolic syndrome were included in concordance with International Diabetes Federation criteria. Serum
resistin levels in both cases and controls were compared. SPSS 20 was used for statistical analysis. Eighty-three patients
with metabolic syndrome were enrolled and compared with 81 healthy unmatched controls. Obesity indices, blood pressure,
lipid profile, fasting blood sugar, insulin resistance and serum resistin levels were evaluated. Predictive values of resistin
for MetS were analyzed using odds ratios.
Results: Significantly elevated levels of resistin were found in subjects with metabolic syndrome compared to healthy
controls (8.23±4.43 vs 6.82±3.64 ng/mL, p<0.05). The odds ratio (95% confidence interval) for metabolic syndrome in
subjects having higher resistin were: males:2.62[1.11–6.19], females: 2.81[1.05–7.49], all Ptrend<0.05.For individual
components of metabolic syndrome, we found the odds ratio to be greatest for hypertension, fasting blood sugar, and insulin
resistance; 2.64, 4.83, 2.85, respectively, all Ptrend<0.05.
Conclusion: The present study suggests significant association of resistin with components of metabolic syndrome such
as hypertension, fasting blood sugar, and insulin resistance. Compared to healthy controls, subjects with MetS had significantly
higher resistin levels. Further research is required to incorporate this biomarker in clinical setting.

References

Ford ES. The metabolic syndrome and mortality from

cardiovascular disease and all-causes: findings from the

National Health and Nutrition Examination Survey II Mortality

Study. Atherosclerosis. 2004; 173(2):309-14.

Han TS, Lean ME. A clinical perspective of obesity, metabolic

syndrome and cardiovascular disease. JRSM Cardiovasc Dis.

; 5:1-13.

Tripathi D, Kant S, Pandey S, Ehtesham NZ. Resistin in

metabolism, inflammation, and disease. FEBS J. 2020;

(15):3141-3149. doi: 10.1111/febs.15322.

Al Hannan F, Culligan KG. Human resistin and the RELM

of Inflammation in diabesity. Diabetol Metab Syndr. 2015 ;

:54. doi: 10.1186/s13098-015-0050-3.

Liu W, Zhou X, Li Y, Zhang S, Cai X, Zhang R, Gong S, Han

X, Ji L. Serum leptin, resistin, and adiponectin levels in obese

and non-obese patients with newly diagnosed type 2 diabetes

mellitus: A population-based study. Medicine.2020;

(6):e19052. doi: 10.1097/MD.0000000000019052.

Yang G, Li L, Tang Y, Boden G. Short-term pioglitazone

treatment prevents free fatty acid-induced hepatic insulin

resistance in normal rats: possible role of the resistin and

adiponectin. Biochem Biophys Res Commun. 2006;

(4):1190-1196. doi: 10.1016/j.bbrc.2005.11.143.

Yousaf I, Hameed W, Rajput TA. Effect of thiazolidinedione

treatment on resistin levels in insulin resistant Sprague Dawley

Rats. Pak J Physiol. 2015 Jun 30;11(2):8-10.

Sniderman AD, Bhopal R, Prabhakaran D, Sarrafzadegan N,

Tchernof A. Why might South Asians be so susceptible to

central obesity and its atherogenic consequences? The adipose

tissue overflow hypothesis. Int J Epidemiol.2007;36(1):220–5.

doi.org/10.1093/ije/dyl245.

Misra A, Shrivastava U. Obesity and dyslipidemia in South

Asians. Nutrients. 2013; 5(7):2708-2733. doi:10.3390

/nu5072708

Imam K, Yousaf I, Waqas S. Effect of thiazolidinediones on

adipocytokines and lipid profile in insulin resistant

spraguedawley rats. Pak J Physiol. 2017; 13(4),3-6.

Alberti KG, Zimmet P, Shaw J; IDF Epidemiology Task Force

Consensus Group. The metabolic syndrome--a new worldwide

definition. Lancet. 2005; 366(9491):1059-1062. doi:

1016/S0140-6736(05)67402-8.

Chen BH, Song Y, Ding EL, Roberts CK, Manson JE, Rifai

N et al. Circulating levels of resistin and risk of type 2 diabetes

in men and women: results from two prospective cohorts.

Diabetes Care. 2009; 32(2):329-334. doi: 10.2337/dc08-1625.

Su KZ, Li YR, Zhang D, Yuan JH, Zhang CS, Liu Y, Song

LM, Lin Q, Li MW, Dong J. Relation of Circulating Resistin

to Insulin Resistance in Type 2 Diabetes and Obesity: A

Systematic Review and Meta-Analysis. Front Physiol. 2019;

:1399. doi: 10.3389/fphys.2019.01399.

Zahary MN, Harun NS, Yahaya R, Nik Him NAS, Rohin

MAK, Ridzwan NH, Jumli MN, Wan Jusoh AF. Serum

adiponectin and resistin: Correlation with metabolic syndrome

and its associated criteria among temiar subtribe in Malaysia.

Diabetes Metab Syndr. 2019 May-Jun;13(3):2015-2019. doi:

1016/j.dsx.2019.04.048.

Mostafazadeh M, Haiaty S, Rastqar A, Keshvari M.

Correlation Between Resistin Level and Metabolic Syndrome

Component: A Review. Horm Metab Res 2018; 50: 521–536.

Hsu BG, Lee C-J, Yang CF, Chen YC, Wang JH. High serum

resistin levels are associated with peripheral artery disease in

the hypertensive patients. BMC Cardiovasc Disord. 2017;

: 80

Zhang Y, Li Y, Yu L, Zhou L. Association between serum

resistin concentration and hypertension: A systematic review

and meta-analysis. Oncotarget 2017; 8: 41529.

Niaz S, Latif J, Hussain S. Serum resistin: A possible link

between inflammation, hypertension and coronary artery

disease. Pak J Med Sci. 2019; 35(3):641-646. doi:10.12669/

pjms.35.3.274

Niu XH, Li L, Li J-Y, Song Q, Jin M-M, Liu J-X. Serum

resistin positively correlates with serum lipids, but not with

insulin resistance, in first-degree relatives of type-2 diabetes

patients: An observational study in China. Medicine. 2017;

(16): e6622.

Ashfaq F and Farasat T. Association of Serum Resistin with

Indices of Obesity in Young Pakistani Subjects. Pakistan J.

Zool.2017; 49: 1587-1593.

Wijetunge S, Ratnayake RMCJ, Kotakadeniya HMSRB,

Rosairo S, Albracht-Schulte K, Ramalingam L et al. Association

between serum and adipose tissue resistin with dysglycemia

in South Asian women. Nutr & Diabetes. 2019; 9(1):5. doi:

1038/s41387-019-0071-3.

Bilgetekin I, Gönderen K, Üstünsoy S, Yýldýz M. Serum

Resistin Levels in Prediabetic Individuals. Med. J. Bakýrkoy.

; 15(5); 47–54. DOI: 10.4274/BTDMJB.galenos. 2018.

Qibin Qi, Jing Wang, Huaixing Li, Zhijie Yu, Xingwang Ye,

Frank B Hu. Associations of resistin with inflammatory and

fibrinolytic markers, insulin resistance, and metabolic syndrome

in middle-aged and older Chinese. Eur J Endocrinol.

;159(5):585–593.

Marcelino-Rodríguez I, Almeida Gonzalez D, Alemán-Sánchez

JJ, Brito Díaz B, Rodríguez Pérez MdC, Gannar F, et al.Inverse

association of resistin with physical activity in the general

population. PLoS ONE.2017; 12(8): e0182493.

https://doi.org/10.1371/journal.pone.0182493

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Published

2022-04-01

How to Cite

Hingorjo, M. R. ., Rashid, M. N. ., Parveen, N. ., Riaz, L. ., Shahid, R. A. ., & Hasan, Z. . (2022). Association of Resistin with Components of Metabolic Syndrome in Our Local Population. Journal of Bahria University Medical and Dental College, 12(02), 88–92. https://doi.org/10.51985/JBUMDC2021131

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