Association of Resistin with Components of Metabolic Syndrome in Our Local Population
DOI:
https://doi.org/10.51985/JBUMDC2021131Keywords:
Diabetes Mellitus; Metabolic syndrome; ResistinAbstract
Objective: To investigate the association of resistin with components of metabolic syndrome (MetS) in our local population.
Study design & setting: Case-control study, Medical OPD; Lyari General Hospital Karachi (from 15th July 2020 till 15th
December 2020).
Methodology: A total of 164 subjects (83 cases & 81 controls) between the age ranges of 35-65 years were selected.
Subjects with metabolic syndrome were included in concordance with International Diabetes Federation criteria. Serum
resistin levels in both cases and controls were compared. SPSS 20 was used for statistical analysis. Eighty-three patients
with metabolic syndrome were enrolled and compared with 81 healthy unmatched controls. Obesity indices, blood pressure,
lipid profile, fasting blood sugar, insulin resistance and serum resistin levels were evaluated. Predictive values of resistin
for MetS were analyzed using odds ratios.
Results: Significantly elevated levels of resistin were found in subjects with metabolic syndrome compared to healthy
controls (8.23±4.43 vs 6.82±3.64 ng/mL, p<0.05). The odds ratio (95% confidence interval) for metabolic syndrome in
subjects having higher resistin were: males:2.62[1.11–6.19], females: 2.81[1.05–7.49], all Ptrend<0.05.For individual
components of metabolic syndrome, we found the odds ratio to be greatest for hypertension, fasting blood sugar, and insulin
resistance; 2.64, 4.83, 2.85, respectively, all Ptrend<0.05.
Conclusion: The present study suggests significant association of resistin with components of metabolic syndrome such
as hypertension, fasting blood sugar, and insulin resistance. Compared to healthy controls, subjects with MetS had significantly
higher resistin levels. Further research is required to incorporate this biomarker in clinical setting.
References
Ford ES. The metabolic syndrome and mortality from
cardiovascular disease and all-causes: findings from the
National Health and Nutrition Examination Survey II Mortality
Study. Atherosclerosis. 2004; 173(2):309-14.
Han TS, Lean ME. A clinical perspective of obesity, metabolic
syndrome and cardiovascular disease. JRSM Cardiovasc Dis.
; 5:1-13.
Tripathi D, Kant S, Pandey S, Ehtesham NZ. Resistin in
metabolism, inflammation, and disease. FEBS J. 2020;
(15):3141-3149. doi: 10.1111/febs.15322.
Al Hannan F, Culligan KG. Human resistin and the RELM
of Inflammation in diabesity. Diabetol Metab Syndr. 2015 ;
:54. doi: 10.1186/s13098-015-0050-3.
Liu W, Zhou X, Li Y, Zhang S, Cai X, Zhang R, Gong S, Han
X, Ji L. Serum leptin, resistin, and adiponectin levels in obese
and non-obese patients with newly diagnosed type 2 diabetes
mellitus: A population-based study. Medicine.2020;
(6):e19052. doi: 10.1097/MD.0000000000019052.
Yang G, Li L, Tang Y, Boden G. Short-term pioglitazone
treatment prevents free fatty acid-induced hepatic insulin
resistance in normal rats: possible role of the resistin and
adiponectin. Biochem Biophys Res Commun. 2006;
(4):1190-1196. doi: 10.1016/j.bbrc.2005.11.143.
Yousaf I, Hameed W, Rajput TA. Effect of thiazolidinedione
treatment on resistin levels in insulin resistant Sprague Dawley
Rats. Pak J Physiol. 2015 Jun 30;11(2):8-10.
Sniderman AD, Bhopal R, Prabhakaran D, Sarrafzadegan N,
Tchernof A. Why might South Asians be so susceptible to
central obesity and its atherogenic consequences? The adipose
tissue overflow hypothesis. Int J Epidemiol.2007;36(1):220–5.
doi.org/10.1093/ije/dyl245.
Misra A, Shrivastava U. Obesity and dyslipidemia in South
Asians. Nutrients. 2013; 5(7):2708-2733. doi:10.3390
/nu5072708
Imam K, Yousaf I, Waqas S. Effect of thiazolidinediones on
adipocytokines and lipid profile in insulin resistant
spraguedawley rats. Pak J Physiol. 2017; 13(4),3-6.
Alberti KG, Zimmet P, Shaw J; IDF Epidemiology Task Force
Consensus Group. The metabolic syndrome--a new worldwide
definition. Lancet. 2005; 366(9491):1059-1062. doi:
1016/S0140-6736(05)67402-8.
Chen BH, Song Y, Ding EL, Roberts CK, Manson JE, Rifai
N et al. Circulating levels of resistin and risk of type 2 diabetes
in men and women: results from two prospective cohorts.
Diabetes Care. 2009; 32(2):329-334. doi: 10.2337/dc08-1625.
Su KZ, Li YR, Zhang D, Yuan JH, Zhang CS, Liu Y, Song
LM, Lin Q, Li MW, Dong J. Relation of Circulating Resistin
to Insulin Resistance in Type 2 Diabetes and Obesity: A
Systematic Review and Meta-Analysis. Front Physiol. 2019;
:1399. doi: 10.3389/fphys.2019.01399.
Zahary MN, Harun NS, Yahaya R, Nik Him NAS, Rohin
MAK, Ridzwan NH, Jumli MN, Wan Jusoh AF. Serum
adiponectin and resistin: Correlation with metabolic syndrome
and its associated criteria among temiar subtribe in Malaysia.
Diabetes Metab Syndr. 2019 May-Jun;13(3):2015-2019. doi:
1016/j.dsx.2019.04.048.
Mostafazadeh M, Haiaty S, Rastqar A, Keshvari M.
Correlation Between Resistin Level and Metabolic Syndrome
Component: A Review. Horm Metab Res 2018; 50: 521–536.
Hsu BG, Lee C-J, Yang CF, Chen YC, Wang JH. High serum
resistin levels are associated with peripheral artery disease in
the hypertensive patients. BMC Cardiovasc Disord. 2017;
: 80
Zhang Y, Li Y, Yu L, Zhou L. Association between serum
resistin concentration and hypertension: A systematic review
and meta-analysis. Oncotarget 2017; 8: 41529.
Niaz S, Latif J, Hussain S. Serum resistin: A possible link
between inflammation, hypertension and coronary artery
disease. Pak J Med Sci. 2019; 35(3):641-646. doi:10.12669/
pjms.35.3.274
Niu XH, Li L, Li J-Y, Song Q, Jin M-M, Liu J-X. Serum
resistin positively correlates with serum lipids, but not with
insulin resistance, in first-degree relatives of type-2 diabetes
patients: An observational study in China. Medicine. 2017;
(16): e6622.
Ashfaq F and Farasat T. Association of Serum Resistin with
Indices of Obesity in Young Pakistani Subjects. Pakistan J.
Zool.2017; 49: 1587-1593.
Wijetunge S, Ratnayake RMCJ, Kotakadeniya HMSRB,
Rosairo S, Albracht-Schulte K, Ramalingam L et al. Association
between serum and adipose tissue resistin with dysglycemia
in South Asian women. Nutr & Diabetes. 2019; 9(1):5. doi:
1038/s41387-019-0071-3.
Bilgetekin I, Gönderen K, Üstünsoy S, Yýldýz M. Serum
Resistin Levels in Prediabetic Individuals. Med. J. Bakýrkoy.
; 15(5); 47–54. DOI: 10.4274/BTDMJB.galenos. 2018.
Qibin Qi, Jing Wang, Huaixing Li, Zhijie Yu, Xingwang Ye,
Frank B Hu. Associations of resistin with inflammatory and
fibrinolytic markers, insulin resistance, and metabolic syndrome
in middle-aged and older Chinese. Eur J Endocrinol.
;159(5):585–593.
Marcelino-Rodríguez I, Almeida Gonzalez D, Alemán-Sánchez
JJ, Brito Díaz B, Rodríguez Pérez MdC, Gannar F, et al.Inverse
association of resistin with physical activity in the general
population. PLoS ONE.2017; 12(8): e0182493.
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Copyright (c) 2022 Mozaffer Rahim Hingorjo, Muhammad Noman Rashid, Naila Parveen, Lubna Riaz, Riaz Ahmed Shahid, Zainab Hasan
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