Prognostic Factors and Association of Inflammatory Biomarkers with Severity and Mortality in COVID-19
DOI:
https://doi.org/10.51985/JBUMDC054Keywords:
CRP, Mortality, COVID-19, Ferritin, D-dimers, Inflammatory markersAbstract
Objectives: To determine prognostic values and association of inflammatory markers with severity and mortality in COVID-
19 in a hospital based study.
Study design and setting: This retrospective study was conducted from 1st June 2020 to 30th Sept 2020 in Department of
Pathology, Qazi Hussain Ahmed Medical Complex, Nowshera and Medical Teaching Institute, Hayatabad Medical complex
Peshawar.
Methodology: Out of 215, 71 cases were selected that had all relevant information’s on chart available in Blood bank
and department of Pathology.
Results: Out of 71 patients, 54 (76.1%) were males and 17 (23.9%) females. Thirty five (49.3%) had age>55 years while
31 (43.7%) were in age range 36-55 years. The frequency of the different blood groups were; 25 (35.2%) B+ blood group
followed by 19 (26.8%) A+ and 14 (19.7%) O+ blood group. The AUC for d-dimers was (0.725, 95% CI 0.599-0.855)
followed by CRP (0.565 95%CI 0.422-0.7.8) and ferritin (0.519 95%CI 0.36-0.679). The median values of d-dimers was
significantly higher in the deceased as compared to the survivors (p<0.05- Mann Whitney U test).The CRP and ferritin
levels were not significantly different in study groups.
Conclusion: D-dimer is a main prognostic factor that predicts mortality in COVID-19 followed by CRP and serum ferritin
levels. Male gender and patient with age>60 are at risk of worst outcome under the impact of deranged values of inflammatory
mediators. Hospital stay and blood group of patients have no relation with outcome
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Copyright (c) 2021 Hamzullah Khan, Shahtaj Khan, Huma Riaz, Asad Rehman Khattak
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