Ageing ovaries and endometrium in PCOS

Authors

  • Ambreen Usmani
  • Ayesha Qamar
  • Sadaf Sadiq

Keywords:

Polycystic ovaries, hyperandrogenism, infertility, ovarian volume, follicle count, follicle size, uterine area and endometrial thickness.

Abstract

Objective: to measure the outcome of age on ovarian and uterine morphology in women with primary infertility due to polycystic ovarian syndrome (PCOS) Materials and Methods: It was an observational cross sectional study. Two hundred primary infertile women with PCOs were subdivided into age groups (years) 20-30 (group I) and 31- 40 (group II). The ovarian volume (OV), follicles count (FC) and size (FS), uterine area (UA) and endometrial thickness (Endo) were determined by trans- abdominal (TAS) and trans -vaginal scan (TVS) using the ultrasound machine. Unpaired t-test was applied to evaluate the result Results: Comparison between group I and group II was made to evaluate the outcome. A significant raise was noted in the uterine morphology of group II. The UA was 89.99±5.83 v/s 119.0±23.33 (0.001) and endometrial thickness was 0.48±0.11 v/s 0.59±0.13 (0.001). A significant decline was noted in the ovarian morphology of group II; the OV (TAS) was 15.36± 2.56 v/s 10.57±12 (0.001) and TVS showed 15.74±2.23 v/s 10.37±1.08 (0.001). The FC was 14.05±1.56 v/s 12.47±0.89 (0.022) and FS was 9.45±7.98 v/s 4.33±5.88 (0.00). Conclusion: The OV, FC and FS (ovarian morphology) variables decreases in the elder infertile group with PCOs but the uterine morphology variables showed an increase in area with thickening of endometrium in the elder group.

References

Frank S. Polycystic ovarian syndrome. N Engl J Med. 1995; 333; 853-61.

Balen AH, Laven JSE, Tan S, Dewailly D. Ultrasound assessment of the polycystic ovary: international consensus of definition. Hum Reprod Update. 2003; 9 (6): 505-14.

Giudice LC. Endometrium in PCOS: Implantation and predisposition to endocrine CA. Best Pract & Res Clin Endocrinol Metab. 2006; 20 (2): 235-44.

Hunter MH, Sterrett JJ. Polycystic ovary syndrome. Am Fam Physician. 2000; 62 (5): 1079- 88.

Gnoth C, Godehardt E, Frank-Hermann P, Tigges J Freundl. Definition and prevalence of sub-fertility and infertility. Hum Reprod. 2005; 20 (5): 1144-7.

Schmid J, Kirchengast S, Vytiska-Binstorfer, Huber J. Infertility caused by PCOS- health related quality of life among Austrian and Moslem immigrant women in Austria. Hum Reprod. 2004; 19 (10): 2251-7.

Pasquali R, Gambineri A, Pagotto U. Review article: The impact of obesity on reproduction in women with polycystic ovary syndrome. BJOG. 2006; 113 (10): 1148-59.

Gambineri A, Pelusi C, Vicennati V, Pagotto U , Pasquali R. Obesity and the polycystic ovary syndrome. Int J Obes Relat Metab Disord. 2002; 26:883–96.

Pillary OC, Wong LF, Fong T, Crow JC, Benjamin E, Mould T etal. The association between polycystic ovaries and endometrial cancer. Hum Reprod. 2006; 21 (4): 924-9.

Haoula Z, Salman M, Atiomo W. Evaluating the association between endometrial cancer and polycystic ovary syndrome. Hum Reprod. 2012; 27 (5): 1327-31

Anthony C. Ultrasound and Menstrual history in predicting endometrial hyperplasia in polycystic ovary syndrome. Journal of Obstet Gynecol. 2001; 98 (2): 325-31.

Park JC, Lim SY, Jang TK, Bae JG, Kim JI, Rhee JH. Endometrial histology and predictable clinical factors for endometrial disease in women with polycystic ovary syndrome. Clin Exp Reprod Med. Mar 2011; 38(1): 42–6.

Ehrmann DA. Polycystic ovary syndrome. N Engl J Med. 2005; 352:1223–36.

Usmani A, Rehman R, Ahktar Z. Association of body mass index and dietary habits with ovarian and uterine morphology with subfertile polycystic ovarian syndrome. J Postgrad Med Inst. 2014; 28(2):133-8.

Iatrakis G, Tsionis C, Adonakis G, Stoikidou M, Anthouli-Anagnostopoulou F, Parava M, et al. Polycystic ovarian syndrome, insulin resistance and thickness of the endometrium. Eur J Obstet Gynecol Reprod Biol. 2006; 127:218–21.

Bu Z, Kuok K, Meng Jie, Wang Rui, Xu B, Zang H. The relationship between polycystic ovary syndrome, glucose tolerance status and serum preptin level. Reprod Biol Endocrinol. 2012; 10:10-13

Usmani A, Islam Z, Akhtar Z. Comparison of female reproductive organs morphology between fertile and infertile women with polycystic ovaries. JPMI. 2013; 27(1):48-54.

Zaidi S, Usmani A, Shokh IS, Alam SE. A comparison of ovarian reserve and BMI between fertile and subfertile women: A Karachi Study. JCPSP. 2009; Vol 19(1):21-4.

Usmani A, Anjum R, Shafi S. Ultrasonic measurement of female pelvic reproductive organs and comparison of BMI between fertile and infertile women. JRMC. 2012; 16(2):159-61.

Stein IF, Leventhal ML. Amenorrhea associated with bilateral polycystic ovaries. Am J Obstet Gynecol. 1935; 29:181-91.

Rehman R, Hussain Z, Siddiq AA. Role of Progesterone in human embryo implantation RMJ. 2012; 37(2): 194-8.

Lam PM, Raine Fenning N. The role of three dimensional ultrasonography in polycystic ovary syndrome. Hum Reprod. 2006; 21(9):2209-15.

Usmani A, Shokh IS. Ovarian reserve in fertile women as determined by ultrasonography. JDUHS. 2007; 1(2):69-73.

Usmani A, R Rehana, Akhtar Z. Association of body mass index and dietary habits with ovarian and uterine morphology with subfertile polycystic ovarian syndrome. J Postgrad Med Inst. 2014; 28(2):133-8.

Lui N, Ma Yanmin, Wang S. Association of genetic variants of luteinizing hormone, Luteinizing hormone receptor and polycystic ovary syndrome. Reprod Biol Endocrinol. 2012; 10:36.

Downloads

Published

2013-12-12

How to Cite

Usmani, A. ., Qamar, . A. ., & Sadiq, S. . (2013). Ageing ovaries and endometrium in PCOS. Journal of Bahria University Medical and Dental College, 3(2), 69–74. Retrieved from https://jbumdc.bahria.edu.pk/index.php/ojs/article/view/60

Issue

Section

Original Articles