Association of Hyperuricemia With Hypertension In Pakistani Population

Authors

  • Attia Khaliq
  • Tariq , Abdul Moueed
  • Karamat ali
  • Shahzeb Ahmad Satti
  • Shahzeb Ahmad Rehman
  • Hafiz Yasir Rehman

DOI:

https://doi.org/10.51985/JBUMDC2019042

Abstract

Objective: To find an association between Hyperuricemia and Hypertension in patients presenting in outpatients department
for regular check-up.
Study design and Setting: Case Control Study design conducted at Pak Emirates Military Hospital Rawalpindi (PEMH),
Medical Outpatient department (OPD) from 4th Feb, 2017 to 4th Aug, 2017.
Methodology: A total of 200 patients, with 100 cases and 100 controls fulfilling the selection criteria were included in
the study, which were selected from Medical OPD of PEMH. An informed written consent was taken. The Demographic
such as age, gender were obtained. Veriable upon selection into study group, the blood samples were taken and two groups
of patients were made on the basis of normal or raised uric acid levels. The Serum Uric Acid (SUA) was measured in the
patients. Then blood pressure was measured by using sphygmomanometer by researchers themselves. If BP level was
>140/90mmHg on 2 separate occasions, or patient is already a known case of hypertension, then hypertension was labeled.
Results: The mean age (years) in the study was 54.79 + 8.96. There were 136 (68%) male and 64 (32%) female patients.
The frequency and percentage of hypertension in cases and control groups was (84%) and (41%) patients respectively
which was statistically significant with a p-value of 0.000. The Odds ratio was found to be 7.55.
Conclusion: It was concluded that there was an association found between Hyperuricemia and Hypertension.

References

Grayson PC, Kim SY, LaValley M, Choi HK. Hyperuricemia and incident hypertension: a systematic review and metaanalysis. Arthritis care & research. 2011;63(1):102-10

Wang J, Qin T, Chen J, Li Y, Wang L, Huang H, et al. Hyperuricemia and risk of incident hypertension: a systematic review and meta-analysis of observational studies. PloS one. 2014;9(12):e114259.

Borghi C, Rosei EA, Bardin T, Dawson J, Dominiczak A, Kielstein JT, et al. Serum uric acid and the risk of cardiovascular and renal disease. Journal of hypertension. 2015;33(9):1729- 41

Tsai C-W, Lin S-Y, Kuo C-C, Huang C-C. Serum Uric Acid and Progression of Kidney Disease: A Longitudinal Analysis and Mini-Review. PloS one. 2017;12(1):e0170393.

Takahashi A, Takabatake Y, Isaka Y, Saitoh T, Yoshimori T. Hyperuricemia-induced inflammasome and kidney diseases. Nephrology Dialysis Transplantation. 2015;31(6):890-6.

Mills KT, Bundy JD, Kelly TN, Reed JE, Kearney PM, Reynolds K, et al. Global Burden of Hypertension: Analysis of Population-based Studies from 89 Countries. Journal of Hypertension. 2015;33:e2.

Kanbay M, Jensen T, Solak Y, Le M, Roncal-Jimenez C, Rivard C, et al. Uric acid in metabolic syndrome: from an innocent bystander to a central player. European journal of internal medicine. 2016;29:3-8.

Yokokawa H, Fukuda H, Suzuki A, Fujibayashi K, Naito T, Uehara Y, et al. Association between serum uric acid levels/hyperuricemia and hypertension among 85,286 Japanese workers. The Journal of Clinical Hypertension. 2016;18(1):53- 9.

Mallat SG, Al Kattar S, Tanios BY, Jurjus A. Hyperuricemia, hypertension, and chronic kidney disease: an emerging association. Current hypertension reports. 2016;18(10):74.

Geraci G, Mulè G, Mogavero M, Geraci C, Nardi E, Cottone S. Association Between Uric Acid and Renal Hemodynamics: Pathophysiological Implications for Renal Damage in Hypertensive Patients. The Journal of Clinical Hypertension. 2016;18(10):1007-14.

Redon P, Maloberti A, Facchetti R, Redon J, Lurbe E, Bombelli M, et al. Gender-related differences in serum uric acid in treated hypertensive patients from central and east European countries: findings from the Blood Pressure control rate and CArdiovascular Risk profilE study. Journal of Hypertension. 2019;37(2):380-8.

Lin X, Wang X, Li X, Song L, Meng Z, Yang Q, et al. Gender- and Age-Specific Differences in the Association of Hyperuricemia and Hypertension: A Cross-Sectional Study. International Journal of Endocrinology. 2019;2019:9.

Marrs CC, Rahman M, Dixon L, Olson G. The association of hyperuricemia and immediate postpartum hypertension in women without a diagnosis of chronic hypertension. Hypertension in Pregnancy. 2018;37(3):126-30.

Chen Y-Y, Kao T-W, Yang H-F, Chou C-W, Wu C-J, Lai CH, et al. The association of uric acid with the risk of metabolic syndrome, arterial hypertension or diabetes in young subjectsAn observational study. Clinica Chimica Acta. 2018;478:68- 73.

Saladini F, Mos L, Fania C, Garavelli G, Casiglia E, Palatini P. Regular physical activity prevents development of hypertension in young people with hyperuricemia. Journal of hypertension. 2017;35(5):994-1001.

Yokokawa H, Fukuda H, Suzuki A, Fujibayashi K, Naito T, Uehara Y, et al. Association Between Serum Uric Acid Levels/Hyperuricemia and Hypertension Among 85,286 Japanese Workers. Journal of clinical hypertension (Greenwich, Conn). 2016;18(1):53-9.

Krishnan E. Interaction of inflammation, hyperuricemia, and the prevalence of hypertension among adults free of metabolic syndrome: NHANES 2009-2010. Journal of the American Heart Association. 2014;3(2):e000157.

Sylvia CM, Some F, Kimaiyo S, Kwobah C, Oyoo G. Prevalence and risk factors for hyperuricemia among patients with hypertension at Moi Teaching and Referral Hospital, Eldoret, Kenya. African Journal of Rheumatology. 2018;6(1):3- 9.

Kuwabara M, Niwa K, Nishi Y, Mizuno A, Asano T, Masuda K, et al. Relationship between serum uric acid levels and hypertension among Japanese individuals not treated for hyperuricemia and hypertension. Hypertension research : official journal of the Japanese Society of Hypertension. 2014;37(8):785-9.

Ahmed N, Anwar W, Waqas H. Obesity, hyperlipidemia, and hyperuraecemia in young and old hypertensive patients. Journal of Ayub Medical College Abbottabad. 2009;21(4):53- 6.

Kearney PM, Whelton M, Reynolds K, Muntner P, Whelton PK, He J. Global burden of hypertension: analysis of worldwide data. The lancet. 2005;365(9455):217-23.

Goyal A, Kahlon P, Jain D, Soni RK, Gulati R, Chhabra ST, et al. Trend in prevalence of coronary artery disease and risk factors over two decades in rural Punjab. Heart Asia. 2017;9(2):e010938-e.

Patel P, Ordunez P, DiPette D, Escobar MC, Hassell T, Wyss F, et al. Improved Blood Pressure Control to Reduce Cardiovascular Disease Morbidity and Mortality: The Standardized Hypertension Treatment and Prevention Project. The Journal of Clinical Hypertension. 2016;18(12):1284-94.

Acevedo A, Benavides J, Chowdhury M, Lopez M, Pena L, Montenegro A, et al. Hyperuricemia and Cardiovascular Disease in Patients with Hypertension. Connecticut medicine. 2016;80(2):85-90.

Gois PHF, de Moraes Souza ER. Pharmacotherapy for hyperuricemia in hypertensive patients. Cochrane Database of Systematic Reviews. 2017(4).

Madero M, Castellanos FER, Jalal D, Villalobos-Martín M, Salazar J, Vazquez-Rangel A, et al. A pilot study on the impact of a low fructose diet and allopurinol on clinic blood pressure among overweight and prehypertensive subjects: a randomized placebo controlled trial. Journal of the American Society of Hypertension. 2015;9(11):837-44.

Abeles AM. Hyperuricemia, gout, and cardiovascular disease: an update. Current rheumatology reports. 2015;17(3):13.

Poudel B, Yadav BK, Kumar A, Jha B, Raut KB. Serum uric acid level in newly diagnosed essential hypertension in a Nepalese population: a hospital based cross sectional study. Asian Pacific journal of tropical biomedicine. 2014;4(1):59- 64.

Jawed S, Khawaja TF, Sultan MA, Ahmad S. The effect of essential hypertension on serum uric acid level. Biomedica (Lahore). 2005:98-102.

Oumar BH, Ichaka M, Kéita MA, Adama D, Bella DI, Souleymane C, et al. Prevalence of Hyperuricemia (HU) in Arterial Hypertension. Science. 2015;4(4):76-9.

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Published

2010-06-07

How to Cite

Khaliq, A., Moueed, T. , A. ., ali, K. ., Satti, S. A., Rehman, S. A., & Rehman, H. Y. . (2010). Association of Hyperuricemia With Hypertension In Pakistani Population. Journal of Bahria University Medical and Dental College, 10(2), 98–101. https://doi.org/10.51985/JBUMDC2019042

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Original Articles