Risk Factors Associated With Sino-Nasal Polyposis And Its Relationship With The Occupational Inhalants
DOI:
https://doi.org/10.51985/JBUMDC2018091Keywords:
Nasal polyps, nasal obstruction, risk factorAbstract
Objective: To determine the risk factors associated with sino-nasal polyposis and its relationship with the exposure of
occupational inhalants in patients presenting in a tertiary care hospital of Karachi.
Study design and Settings: Cross-sectional study conducted at department of otorhino-laryngology Karachi Medical &
Dental College and Abbasi Shaheed Hospital Karachi for a period of two and a half years from October 2015 to April 2018.
Methodology: Total number of patients included for this study were 221 patients with diagnosis of bilateral and multiple
nasal polyposis with age greater than 10 years. Specifically, designed proforma was used for data collection specially in
relation with occupation and exposure to different occupational inhalants and entered in SPSS version 23 for analysis.
Results: There were 133 male and 88 female patient with a mean age was 36.16 ± 12.33 years. Mostly patients belonged
to poor socio-economic status i.e. 133 (60.70%). Allergic rhinitis or nasal allergy was the most common risk factor present
in 114 patients (51.6%) while aspirin hypersensitivity was the least common risk factor present in only 19 patients (8.5%).
Most of the patients (76 or 34.4%) were related with one or the other form of agriculture and were exposed to different
occupational inhalants like mud, pollens, animals and plants.
Conclusions: Nasal allergy is the most common risk factor and occupational inhalant specially related with agriculture,
poultry and pets are the common agents responsible for nasal polyposis in our local population.
References
Edhtedari F, Ghadderi A, Kashef A, Askari M. Role of IgE low-affinity receptor (CD23) in pathogenesis of nasal polyp. Iranian J Med Sci., 2003; 28(1): 29-32
Maharjan S, Neopane P, Tiwari M, Parajuli R. Nasal polyposis: A review. Global Journal of Otolaryngology, 2017; 8(2): 1-3.
Dalziel K, Stein K, Round A et al. Systematic review of endoscopic sinus surgery for nasal polyps. Health Techol Assess, 2003; 7(17): 1-159.
Alam M, Fakir Y, Chowdhury A. A review of nasal polyposis and surgical management. Bangladesh J Otorhinolaryngol., 2008; 14(2): 71-74.
Hedman J, Kaprio J, Poussa T, et al. Prevalence of asthma, aspirin intolerance, nasal polyposis and chronic obstructive pulmonary disease in a population-based study. Int J Epidemiol, 1999; 28:717-22.
Newton JR, Ah-See KW. A review of nasal polyposis. Ther Clin Risk Manag. 2008;4(2):507-512.
Fokkens WJ, Lund V, Bachert C, Clement P, Hellings P et al. European position paper of rhinosinustis and nasal polyp. Rhinol., 2005; Suppl 18: 1-87.
Osguthorpe JD, Hadley JA. Rhinosinusitis. Current concepts in evaluation and management. Med Clin North Am., 1999; 83 (1): 27-41.
Soltankhah MS, Majidi MR, Shabani Sh. Medical treatment of nasal polyps: a review. Rev Clin Med, 2015; 2 (1): 24-27.
Luxenburger W, Posch G, Berghold, et al. HLA patterns in patients with nasal polyposis. Eur Arch Otorhinolaryngol, 2000; 257: 137-9.
Akdis CA, Bachert C, Cingi C, et al. Endotypes and phenotypes of chronic rhinosinusitis: a PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology. J Allergy Clin Immunol. 2013; 131:1479–90.
Fokkens WJ, Lund VJ, Mullol J, et al. European Position Paper on Rhinosinusitis and Nasal Polyps. Rhinol 2012; Suppl. 23:1–298.
Bousquet PJ, Demoly P, Devillier P, et al. Impact of allergic rhinitis symptoms on quality of life in primary care. Int Arch Allergy Immunol 2012; 160: 393-400.
Larsen K, Tos M. The estimated incidence of symptomatic nasal polyps. Acta Otolaryngol. 2002; 122:179–82.
Bateman ND, Fahy C, Woolford TJ: Nasal polyps still more questions than answers. J Laryngol Otol 2003; 117(1): 1-9.
Tan BK, Chandra RK, Pollak J, et al. Incidence and associated premorbid diagnoses of patients with chronic rhinosinusitis. J Allergy Clin Immunol. 2013; 131:1350–60. [PubMed: 23541327]
Chukuezi AB. Nasal polyposis in Nigerian District Hospital. West Afr J Med. 1994; 13(4): 231-3.
Cimmino M, Carvaliere M, Mardone M, Plantulli A,Orefice A, Esposito V, et al. Clinical characteristics and genotype analysis of patients with cystic fibrosis and nasal polyposis. Clin Otolaryngol. 2003; 28: 125-32.
Bosquet J, Van Cauwenberge P, Khaltaev N. Allergic rhinitis and its impact on asthma. J Allergy Clin Immunol, 2001; 108(5 Suppl): S 147-334.
Salvin RG, Cannon RE, Friedman WH, Palitang E, Sundaram M. Sinusitis and bronchial asthma. J Allergy Clin Immunol 1980; 66(3): 250-7.
Bresciani M, Paradis L, Roches A, Vernhet H, Vachier I, Godard P, et.al. Rhinosinusitis in severe asthma. J Allergy Clin Immunol 2001; 107(1):73-80.
Nanda MS, Bhatia S, Gupta V. Epidemiology of nasal polyps in hilly areas and its risk factors. Int J Otorhinolaryngol Head Neck Surg. 2017; 3(1): 77-81.
Jahromi AM, Pour AS. The Epidemiological and Clinical Aspects of Nasal Polyps that Require Surgery. Iran J Otorhinolaryngol. 2012; 24(67): 75–78.
Khadim MT, Ahmed S, Akhtar F, Jaffar SR, Mirza IA, Anwar J, Tahir H. Clinicopathological Characteristics of Nasal Polyps with Chronic Sinusitis J Bahria Uni Med Den Coll., 2016; 6(3): 178-181.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2019 Qaisar Sajad, Ayub Musani, Faheem Ahmed Khan
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Journal of Bahria University Medical & Dental College is an open access journal and is licensed under CC BY-NC 4.0. which permits unrestricted non commercial use, distribution and reproduction in any medium, provided the original work is properly cited. To view a copy of this license, visit https://creativecommons.org/licenses/by-nc/4.0