Effect of Metformin Versus Diet and Exercise on Ovulation & Menstrual Regularity in PCOS

Authors

  • Nasim Karim
  • Khalid Mustafa
  • Talea Hoor
  • Riffat Farooqui

Keywords:

Polycystic ovary syndrome , Metformin, Diet & exercise, Menstrual regularity, Ovulation.

Abstract

To compare the effects of metformin with diet & exercise on ovulation & menstrual regularity in PCOS infertile women .
Study Design: Randomized clinical trial.
Place & Duration of study: Private hospital infertility clinic at Karachi from 2001-2004.
Patients & Methods: One hundred & eleven PCOS women with primary infertility were enrolled. and divided into group A & B with 57 & 54 patients
respectively. Group A received tablet metformin 500mg thrice daily along with diet & exercise advice while group B was kept on diet & exercise alone
(30-60 minutes walk daily & avoidance of oily foods, red meat & bakery products) for a period of 90 days. Menstrual regularity & plasma progesterone
level were evaluated at day-0 and day-90. Fasting serum glucose, insulin, follicle stimulating hormone, luteinizing hormone, prolactin, testosterone &
ultrasound pelvis were done at day- 0 for diagnosis of PCOS.
Results: 100 patients completed the study. 50 patients in each group.In group A, 44 (88%) patients developed regular cycles with statistically significant
increase in serum progesterone whereas in group B only 3(6%) patients developed regular cycles with non-significant increase in serum progesterone level
from day-0 to day-90. Group A showed ovulation in 82% patients in comparison to Group B where ovulation occurred in only 6% of patients.
Conclusion: Metformin produced beneficial effects in comparison to diet & exercise alone in PCOS infertile women.

References

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Published

2012-01-02

How to Cite

Karim, N. ., Mustafa, K. ., Hoor, T. ., & Farooqui, R. . (2012). Effect of Metformin Versus Diet and Exercise on Ovulation & Menstrual Regularity in PCOS. Journal of Bahria University Medical and Dental College, 2(1), 17–23. Retrieved from https://jbumdc.bahria.edu.pk/index.php/ojs/article/view/29

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