Liraglutide - A Promising Approach Against Obesity

Authors

  • Nabila Rafi
  • Muhammad Sajid Abbas Jaffri
  • Kamran Yousuf

DOI:

https://doi.org/10.51985/JBUMDC2024455

Abstract

 Obesity has emerged as a global chronic condition that poses a significant public health issue. The World Health Organisation (WHO) has reported a significant increase in obesity rates, which have nearly quadrupled since 1975.1 Thus, it is crucial to consider the significant health risks associated with this issue, including the potential for developing type 2 diabetes, cardiovascular diseases, endocrinal malignancies, and musculoskeletal difficulties. Furthermore, obesity incurs substantial expenses for healthcare systems and populations at large.

References

1. Boutari, C. and C.S. Mantzoros, A 2022 update on the epidemiology of obesity and a call to action: as its twin COVID-

19 pandemic appears to be receding, the obesity and dysmetabolism pandemic continues to rage on. Metabolism, 2022.

133: p. 155217, DOI: 10.1016/j.metabol.2022.155217 .

2. Hecker, J., K. Freijer, M. Hiligsmann, and S.M.A.A. Evers,

Burden of disease study of overweight and obesity; the societal

impact in terms of cost-of-illness and health-related quality

of life. BMC Public Health, 2022. 22(1): p. 46; https://doi.org/10.1186/s12889-021-12449-2.

3. Montesi, L., M. El Ghoch, L. Brodosi, S. Calugi, G. Marchesini,

and R. Dalle Grave, Long-term weight loss maintenance for

obesity: a multidisciplinary approach. Diabetes Metab Syndr

Obes, 2016. 9: p. 37-46 doi: 10.2147/DMSO.S89836.

4. Greenway, F.L., Physiological adaptations to weight loss and

factors favouring weight regain. Int J Obes (Lond), 2015.

39(8): p. 1188-96; DOI: 10.1038/ijo.2015.59 .

5. Lin, C.-H., L. Shao, Y.-M. Zhang, Y.-J. Tu, Y. Zhang, B.

Tomlinson, P. Chan, and Z. Liu, An evaluation of liraglutide

including its efficacy and safety for the treatment of obesity.

Expert opinion on pharmacotherapy, 2020. 21(3): p. 275-285;

DOI: 10.1080/14656566.2019.1695779 .

6. Nadkarni, P., O.G. Chepurny, and G.G. Holz, Regulation of

glucose homeostasis by GLP-1. Prog Mol Biol Transl Sci,

2014. 121: p. 23-65; DOI: 10.1016/B978-0-12-800101-

1.00002-8.

7. Maselli, D., J. Atieh, M.M. Clark, D. Eckert, A. Taylor, P.

Carlson, D.D. Burton, I. Busciglio, W.S. Harmsen, A. Vella,

and A. Acosta, Effects of liraglutide on gastrointestinal

functions and weight in obesity: A randomized clinical and

pharmacogenomic trial. 2022. 30(8): p. 1608-1620; DOI:

10.1002/oby.23481 .

8. Papaetis, G.S., Liraglutide therapy in a prediabetic state:

rethinking the evidence. Current Diabetes Reviews, 2020.

16(7): p. 699-715; DOI: 10.2174/1573399816666191

230113446.

9. Wajcberg, E. and A. Amarah, Liraglutide in the management

of type 2 diabetes. Drug Des Devel Ther, 2010. 4: p. 279-90;

doi: 10.2147/DDDT.S10180 .

10. Babic, I., D. Sellers, P.L. Else, J. Nealon, A.L. Osborne, N.

Pai, and K. Weston-Green, Effect of liraglutide on neural and

peripheral markers of metabolic function during antipsychotic

treatment in rats. Journal of Psychopharmacology, 2021.

35(3): p. 284-302; DOI: 10.1177/0269881120981377.

11. Kumari, P., M. Nakata, B.Y. Zhang, Z. Otgon-Uul, and T.

Yada, GLP-1 receptor agonist liraglutide exerts central action

to induce â-cell proliferation through medulla to vagal pathway

in mice. Biochemical and Biophysical Research Communicat i o n s , 2 0 1 8 . 4 9 9 ( 3 ) : p . 6 1 8 - 6 2 5 ; D O I :

10.1016/j.bbrc.2018.03.199.

12. Trenson, L., S. Trenson, F. van Nes, C. Moyson, M. Lannoo,

E. Deleus, A. Meulemans, C. Matthys, A. Mertens, B. Van

der Schueren, and R. Vangoitsenhoven, Liraglutide for Weight

Management in the Real World: Significant Weight Loss Even

if the Maximal Daily Dose Is Not Achieved. Obes Facts,

2022. 15(1): p. 83-89; DOI: 10.1159/000520217.

13. Blackman, A., G.D. Foster, G. Zammit, R. Rosenberg, L.

Aronne, T. Wadden, B. Claudius, C.B. Jensen, and E. Mignot,

Effect of liraglutide 3.0 mg in individuals with obesity and

moderate or severe obstructive sleep apnea: the SCALE Sleep

Apnea randomized clinical trial. Int J Obes (Lond), 2016.

40(8): p. 1310-9; doi: 10.1038/ijo.2016.52.

14. Astrup, A., S. Rössner, L. Van Gaal, A. Rissanen, L. Niskanen,

M. Hakim, J. Madsen, M. Rasmussen, and M. Lean, Effects

of liraglutide in the treatment of obesity: a randomised, doubleblind, placebo-controlled study. Lancet, 2009. 374: p. 1606-

16; DOI: 10.1016/S0140-6736(09)61375-1.

15. Gorgojo-Martínez, J.J., P. Mezquita-Raya, J. Carretero-Gómez,

A. Castro, A. Cebrián-Cuenca, A. de Torres-Sánchez, M.D.

García-de-Lucas, J. Núñez, J.C. Obaya, and M.J. Soler, Clinical

recommendations to manage gastrointestinal adverse events

in patients treated with Glp-1 receptor agonists: a multidisciplinary expert consensus. Journal of Clinical Medicine, 2022.

12(1): p. 145; DOI: 10.3390/jcm12010145.

16. Seo, Y.-G., Side Effects Associated with Liraglutide Treatment

for Obesity as Well as Diabetes. Journal of Obesity & Metabolic

Syndrome, 2020. 30; doi: 10.7570/jomes20059.

17. Dimitrios, P., D. Michael, K. Vasilios, S. Konstantinos, I.

Konstantinos, P. Konstantinos, B. Spyridon, and K. Asterios,

Liraglutide as adjunct to insulin treatment in patients with

type 1 diabetes: a systematic review and meta-analysis. Current

Diabetes Reviews, 2020. 16(4): p. 313-326; DOI:

10.2174/1573399815666190614141918.

18. Javed, H., G.S. Kogilathota Jagirdhar, R. Kashyap, and P.H.

Vekaria, Liraglutide-Induced Pancreatitis: A Case Report and

Literature Review. Cureus, 2023. 15(4): p. e38263; DOI:

10.7759/cureus.38263.

19. Nafisah, S.B. and D. Almatrafi, Liraglutide overdose: A case

report and an updated review. 2020. 20(1): p. 46-49; DOI:

10.4103/2452-2473.276386.

20. Kalra, S., Follow the LEADER-Liraglutide Effect and Action

in Diabetes: Evaluation of Cardiovascular Outcome Results

Trial. Diabetes Ther, 2016. 7(4): p. 601-609; doi:

10.1007/s13300-016-0197-4.

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Published

2025-01-07

How to Cite

Rafi, N., Jaffri, M. S. A., & Yousuf, K. (2025). Liraglutide - A Promising Approach Against Obesity. Journal of Bahria University Medical and Dental College, 15(01), 64–66. https://doi.org/10.51985/JBUMDC2024455

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