Comparative Study of Lipid Profile in Multibacillary and Paucibacillary Leprosy Patients
Keywords:
Leprosy, Lipid profile, Multibacillary(MB), Paucibacillary (PB)Abstract
Objective: To evaluate the lipid profile in Multibacillary and Paucibacillary leprosy subjects and compare them with age and
sex matched healthy control subjects.
Materials and Methods: This observational study was performed after approval from BASR, University of Karachi in the
Department of Biochemistry, University of Karachi, from December 2014 to November, 2015. Present study was conducted
in 42 newly diagnosed leprosy patients of both sexes and all ages were included in this study. The diagnosis were on clinical
ground and bacterial examination by slit skin smear test, and are classified in two groups, Paucibacillary (PB) and Multibacillary
(MB), based on the WHO guide lines. 1-5 skin lesions were regarded as PB with no acid fast rods on the smear and skin lesions
more than 5 were regarded as MB. A positive bacterial index classifies the patient as MB, regardless of the number of skin
lesions with bacteria visible on a smear.
Results: A total of 30 control subjects and 42 leprosy patients among 24 Multibacillary and 18 Paucibacillary leprosy were
recruited for this study. Biophysical parameters in Multibacillary and Paucibacillary subjects were completely non significant
when compared with control group.In biochemical parameters among Multibacillary and Paucibacillary leprosy cases, all the
lipid fractions total cholesterol, triglycerides and LDL -cholesterol were significantly decreased (p<0.05) but HDL –cholesterol
significantly increased (p<0.05) in both Multibacillary and Paucibacillary leprosy groups when compared with control group.
Conclusion: This study showed that, all the lipid fractions except HDL cholesterol were decreased significantly (p<0.05), where
as HDL Cholesterol was increased significantly (p<0.05) in both Multibacillary and Paucibacillary leprosy groups when compared
with control group.
References
Swathi M, Tagore R. Study of oxidative stress in different forms of leprosy. Ind J Derm 2015; 60(3):321-4
Prasad PVS and Kaviarasan PK. Leprosy therapy, past and present: Can we hope to eliminate it. Ind J Der 2010; 55:316-24
World Health Organization. 2002. Leprosy. Global situation. Wkly. Epidemiol. Rec.77:1-8
World Health Organization. Global leprosy situation, beginning of 2008. Wkly. Epidemiol. Rec. 2008;83:293- 300
World Health Organization. Global leprosy situation, 2009. Wkly. Epidemiol. Rec. 200984:333-40
Henrique J P, Gomes R L R, Flávia S, Prevedello C, Mira MT, Eleidi A. Investigation of association between Susceptibility to Leprosy and SNPs inside and near the BCHE Gene of Butyrylcholinesterase. J Trop Med Brazil 2012; doi:10.1155: 1-4
American Leprosy Missions, Inc. About leprosy freque- ntly asked Questions. Retrieved October 2, 2012
Ebenso J, Velema JP. Test-Resest Reliability of the Scree- ning Activity Limitation and Safety Awareness (SALSA) Scale in North-West Nigeria. Lepr Rev 2009; 80:197- 204
John AS, Rao PSS, Das S. Assessment of needs and quality care issues of women with leprosy. Lepr Rev 2010; 81:34-40
Soomro FR, Shaikh GS, Bhatti NS, Baloch J, Abbasi P, Kumari M et al. Deformity and Disability Index in Pat- ients with Leprosy in Larkana District, Sindh, Pakistan. In: Studies on New and Old World Leishmaniases and their Transmission, with Particular References to Ecuador, Argentina and Pakistan Kyowa, Japan. Res Rep Ser No: 7, 2004; 177-81
Watson CL, Popescu E, Boldsen J, Slaus M, Lockwood DNJ. Single Nucleotide Polymorphism Analysis of European Archaeological M. laprae DNA, 2011
Vijayaraghavan R, Suribabu CS, Oommen PK , Panneers- elvam C. Vitamin E reduces reactive oxygen species mediated damage to bio-molecules in leprosy during multi-drug therapy. Curr Trends Biotechnol Pharm 2009; 3:428-39
Cole ST, Eiglmeier K, Parkhill J, James KD, Thomson NR, Wheeler PR et al. Massive gene decay in the leprosy bacillus. Nature 2001; 409:1007-11
Al-Mubarak R, Heiden J V, Broeckling C D, Balagon M, Patrick J. Brennan PJ et al. Serum Metabolomics Reveals Higher Levels of Polyunsaturated Fatty Acids in Lepromatous Leprosy: Potential Markers for Suscepti- bility and Pathogenesis. PLoS Negl Trop Dis. Sept 2011; 5(9): 1303-5
Grossi MAF, Leboeuf MAA, Andrade ARC, Lyon S, Antunes CMF, Sekula SB. The influence of ML. Flow test in leprosy classification. Rev Soc Br Med Trop 2008;41:34-8
Rifai N, Bachorik PS, Albers JJ. Lipids, lipoproteins and apolipoproteins In: Tietz Fundamental Clinical Chemistry, 5th ed. Edited by Burtis CA and Ashwood ER, WB Saunders, Philadelphia, 2001;pp.462-93
Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972; 18:499-502
Rifai N, Warnick GR. Lipids, Lipoproteins, Apolipoprote- ins and other cardiovascular risk factors. In:TIETZ Text- book of clinical chemistry. 4th ed. WB Saunders, Phila- delphia 2006; pp.903-81
Jain M, Petzold CJ, Schelle MW, Leavell MD, Mougous JD, Bertozzi CR et al. Lipidomics reveals control of Mycobacterium tuberculosis virulence lipids via metab- olic coupling. Proc. Natl. Acad. Sci 2007; 104:5133-8
Reed MB, Domenech P, Manca C, Su H, Barczak AK, Kreiswirth BN et al. A glycolipid of hypervirulent tub- erculosis strainsthat inhibits the innate immune response. Nature 2004; 431:84-7
Imaeda T. Electron microscopic analysis of the compon- ents of the laprae cells. Int J lepr 1960; 28:22-37
Gupta A, Koranne RV, Kaul N. Study of serum lipids in leprosy. Ind J Der Ven Lep 2002; 68:262-6
Misra UK, Venkitasubramanian TA. Serum lipids in leprosy by silicic acid column chromatography. Ind J Lepr 1964;32:248-59
Bansal SN, VK Jain, Dayal Sand, RK Nagpal Serum lipid profile in leprosy. Ind J Der Ven Lep 1997; 63:78-81
Kher JR, Baji PS, Ganeriwal SK, Reddy BV, Bulakh PM. Serum lipoproteins in lepromatous leprosy. Lepr Ind 1983; 55:80-5
Ahaley SK, Sardeshmukh AS, Suryakar AN, Samson PD. Correlation of serum lipids and lipoproteins in leprosy. Ind J Lep 1992; 64:91-8
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