Oral Potentially Malignant Disorders: A Comprehensive Review of Diagnostic Approaches and Management Strategies
DOI:
https://doi.org/10.51985/JBUMDC2023223Keywords:
Erythroplakia, Leukoplakia, Oral lichen planus, Oral potentially malignant disorders, Oral submucous fibrosis, TobaccoAbstract
Oral potentially malignant disorders (OPMDs) encompass a group of conditions that have an increased risk of progressing to oral cancer. Timely diagnosis and effective management of these disorders play a crucial role in preventing malignant transformation and improving patient outcomes. This review article provides a comprehensive overview of the diagnostic approaches and management strategies for OPMDs. It discusses the current understanding of OPMDs, highlights the various diagnostic methods available, and explores the evolving landscape of management options. The aim of this review is to enhance the knowledge and awareness of healthcare professionals involved in oral pathology and promote effective decisionmaking in the diagnosis and management of OPMDs.
A thorough understanding of diagnostic approaches and management strategies for oral potentially malignant disorders is essential for dental and medical professionals involved in oral pathology. This review article provides a comprehensive overview of the topic, highlighting the importance of early detection, risk assessment, and interdisciplinary collaboration
References
Warnakulasuriya S. Oral potentially malignant disorders: A
comprehensive review on clinical aspects and management.
Oral oncology. 2020;102:104550. DOI: 10.1016/j.oraloncology
.2019.104550
Kumari P, Debta P, Dixit A. Oral potentially malignant
disorders: etiology, pathogenesis, and transformation into oral
cancer. Frontiers in pharmacology. 2022;13:825266. doi:
3389/fphar.2022.825266
Warnakulasuriya S, Kujan O, Aguirre-Urizar JM, Bagan JV,
González-Moles MÁ, Kerr AR, et al. Oral potentially malignant
disorders: A consensus report from an international seminar
on nomenclature and classification, convened by the WHO
Collaborating Centre for Oral Cancer. Oral diseases. 2021;27(8)
:1862-80. DOI: 10.1111/odi.13704
Parakh MK, Ulaganambi S, Ashifa N, Premkumar R, Jain
AL. Oral potentially malignant disorders: clinical diagnosis
and current screening aids: a narrative review. European
Journal of Cancer Prevention. 2020;29(1):65-72. DOI: 10.1097
/CEJ.0000000000000510
Tanriver G, Soluk Tekkesin M, Ergen O. Automated detection
and classification of oral lesions using deep learning to detect
oral potentially malignant disorders. Cancers. 2021;13(11)
:2766. DOI: 10.3390/cancers13112766
Khan AS, Ahmad S, Ullah Z, Haq M, Farooq MU, Khan M.
Serum p53 antibodies detection in oral squamous cell carcinoma, oral potentially malignant disorders and healthy individuals: A multicentre study. JPMA The Journal of the Pakistan
Medical Association. 2021;71(10):2364-8. DOI:
47391/JPMA.1133
Ranganathan K, Kavitha L. Oral epithelial dysplasia: Classifications and clinical relevance in risk assessment of oral
potentially malignant disorders. Journal of oral and maxillofacial pathology: JOMFP. 2019;23(1):19. DOI: 10.
/jomfp.JOMFP_13_19
DeCoro M, Wilder-Smith P. Potential of optical coherence
tomography for early diagnosis of oral malignancies. Expert
review of anticancer therapy. 2010;10(3):321-9. doi: 10.1586
/era.09.191
Kerr AR, Lodi G. Management of oral potentially malignant
disorders. Oral Diseases. 2021;27(8):2008-25. DOI: 10.1111/
odi.13980
Swain SK. Premalignant lesions of the oral cavity: Current
perspectives. Int J Res Med Sci. 2021;9:1816-22. DOI: https:
//doi.org/10.18203/2320-6012.ijrms20212259
Singh AK, Chauhan R, Anand K, Singh M, Das SR, Sinha
AK. Prevalence and risk factors for oral potentially malignant
disorders in Indian population. Journal of Pharmacy & Bioallied
Sciences. 2021;13(Suppl 1):S398. doi: 10.4103/jpbs. JPBS_
_20
Lorini L, Bescós Atín C, Thavaraj S, Müller-Richter U,
Alberola Ferranti M, Pamias Romero J, et al. Overview of
oral potentially malignant disorders: from risk factors to
specific therapies. Cancers. 2021;13(15):3696. doi:
3390/cancers13153696
Pires FR, Barreto MEZ, Nunes JGR, Carneiro NS, de Azevedo
AB, dos Santos TCRB. Oral potentially malignant disorders:
clinical-pathological study of 684 cases diagnosed in a Brazilian
population. Medicina Oral, Patología Oral y Cirugía Bucal.
;25(1):e84. DOI: 10.4317/medoral.23197
Reddy DI, Narayana ML, Viswambharan V, Chaithanya NR.
Betel quid and tobacco chewing habits and its associated
clinical findings in a rural tertiary care hospital. International
Journal of Otorhinolaryngology and Head and Neck Surgery.
;6(4):732. DOI: https://doi.org/10.18203/issn.2454-5929.
ijohns20201291
Pentenero M, Azzi L, Lodi G, Manfredi M, Varoni E. Chronic
mechanical trauma/irritation and oral carcinoma: A systematic
review showing low evidence to support an association. Oral
diseases. 2022;28(8):2110-8. DOI: 10.1111/odi.14049
Sri S, Ramani P, Premkumar P, Ramshankar V, Ramasubramanian A, Krishnan RP. Prevalence of Human Papillomavirus
(HPV) 16 and 18 in oral malignant and potentially malignant
disorders: A polymerase chain reaction analysis–A comparative
study. Annals of Maxillofacial Surgery. 2021;11(1):doi:
4103/ams.ams_376_20
Shridhar K, Aggarwal A, Walia GK, Gulati S, Geetha A,
Prabhakaran D, et al. Single nucleotide polymorphisms as
markers of genetic susceptibility for oral potentially malignant
disorders risk: Review of evidence to date. Oral Oncology.
;61:146-51. DOI: 10.1016/j.oraloncology.2016.08.005
Iocca O, Sollecito TP, Alawi F, Weinstein GS, Newman JG,
De Virgilio A, et al. Potentially malignant disorders of the
oral cavity and oral dysplasia: A systematic review and metaanalysis of malignant transformation rate by subtype. Head
& neck. 2020;42(3):539-55. DOI: 10.1002/hed.26006
Carrard VC, Van der Waal I. A clinical diagnosis of oral
leukoplakia; A guide for dentists. Medicina oral, patologia
oral y cirugia bucal. 2018;23(1):e59. DOI: 10.4317/ medoral.
Warnakulasuriya S. Clinical features and presentation of oral
potentially malignant disorders. Oral surgery, oral medicine,
oral pathology and oral radiology. 2018;125(6):582-90. DOI:
1016/j.oooo.2018.03.011
Rao NR, Villa A, More CB, Jayasinghe RD, Kerr AR, Johnson
NW. Oral submucous fibrosis: a contemporary narrative
review with a proposed inter-professional approach for an
early diagnosis and clinical management. Journal of Otolaryngology-Head & Neck Surgery. 2020;49(1):1-11. DOI:
1186/s40463-020-0399-7
Shih Y-H, Wang T-H, Shieh T-M, Tseng Y-H. Oral submucous
fibrosis: a review on etiopathogenesis, diagnosis, and therapy.
International journal of molecular sciences. 2019;20(12):2940.
doi: 10.3390/ijms20122940
González-Moles MÁ, Warnakulasuriya S, González-Ruiz I,
González-Ruiz L, Ayen A, Lenouvel D, et al. Worldwide
prevalence of oral lichen planus: A systematic review and
meta-analysis. Oral diseases. 2021;27(4):813-28. DOI:
1111/odi.13323
Vasilovici A, Ungureanu L, Grigore L, Cojocaru E, ªenilã S.
Actinic Cheilitis—From Risk Factors to Therapy. Frontiers
in Medicine. 2022;9:805425.doi.org/ 10.3389/fmed.2 022.
Walsh T, Warnakulasuriya S, Lingen MW, Kerr AR, Ogden
GR, Glenny A-M, et al. Clinical assessment for the detection
of oral cavity cancer and potentially malignant disorders in
apparently healthy adults. Cochrane Database of Systematic
Reviews. 2021(12). DOI: 10.1002/14651858.CD010173.pub3
Gaddikeri K. Clinical-pathological Study Of Patients With
Oral Potentially Malignant Disorders. Int J Acad Med Pharm.
;5(3):609-15. DOI: 10.47009/jamp.2023.5.3.127
Abdul NS. Role of Advanced Diagnostic Aids in the Detection
of Potentially Malignant Disorders and Oral Cancer at an
Early Stage. Cureus. 2023;15(1). doi: 10.7759/cureus.34113
Odell E, Kujan O, Warnakulasuriya S, Sloan P. Oral epithelial
dysplasia: recognition, grading and clinical significance. Oral
diseases. 2021;27(8):1947-76. DOI: 10.1111/odi.13993
Kim DH, Kim SW, Hwang SH. Efficacy of non-invasive
diagnostic methods in the diagnosis and screening of oral
cancer and precancer. Brazilian Journal of Otorhinolaryngology. 2022;88:937-47. DOI: 10.1016/j. bjorl.2020.12.019
H. Alsarraf A, Kujan O, Farah CS. The utility of oral brush
cytology in the early detection of oral cancer and oral potentially malignant disorders: A systematic review. Journal of
Oral Pathology & Medicine. 2018;47(2):104-16. DOI:
1111/jop.12660
Piyarathne NS, Rasnayake R, Angammana R, Chandrasekera
P, Ramachandra S, Weerasekera M, et al. Diagnostic salivary
biomarkers in oral cancer and oral potentially malignant
disorders and their relationships to risk factors–A systematic
review. Expert Review of Molecular Diagnostics.
;21(8):789-807. DOI: 10.1080/14737159.2021.1944106
Shin D, Vigneswaran N, Gillenwater A, Richards-Kortum R.
Advances in fluorescence imaging techniques to detect oral
cancer and its precursors. Future oncology. 2010;6(7):1143-
DOI: 10.2217/fon.10.79
Yap T, Celentano A, Seers C, McCullough MJ, Farah CS.
Molecular diagnostics in oral cancer and oral potentially
malignant disorders—A clinician’s guide. Journal of Oral
Pathology & Medicine. 2020;49(1):1-8. DOI:
1111/jop.12920
Ranganath K, Feng AL, Franco RA, Varvares MA, Faquin
WC, Naunheim MR, et al. Molecular Biomarkers of Malignant
Transformation in Head and Neck Dysplasia. Cancers.
;14(22):5581.doi.org/10.3390/cancers14225581
Ilhan B, Lin K, Guneri P, Wilder-Smith P. Improving oral
cancer outcomes with imaging and artificial intelligence.
Journal of dental research. 2020;99(3):241-8. DOI:
1177/0022034520902128
El Kininy W, Israr M, Toner M, Meaney J, Stassen L. Prospective Comparison of CT scan, MRI and PET/CT in the
Diagnosis of Oral Cancer and Nodal Metastasis. Int J Surg
Res Pract. 2017; 4:050. DOI: 10.23937/2378-3397/1410050
Jäwert F, Nyman J, Olsson E, Adok C, Helmersson M, Öhman
J. Regular clinical follow-up of oral potentially malignant
disorders results in improved survival for patients who develop
oral cancer. Oral oncology. 2021;121:105469. DOI:
1016/j.oraloncology.2021.105469
Borse V, Konwar AN, Buragohain P. Oral cancer diagnosis
and perspectives in India. Sensors International.
;1:100046. doi: 10.1016/j.sintl.2020.100046
Kundoor VKR, Patimeedi A, Roohi S, Maloth KN, Kesidi S,
Masabattula GK. Efficacy of diode laser for the management
of potentially malignant disorders. Journal of lasers in medical
sciences. 2015;6(3):120. DOI: 10.15171/jlms.2015.05
Binnal A, Tadakamadla J, Rajesh G, Tadakamadla SK. Photodynamic therapy for oral potentially malignant disorders:
A systematic review and meta-analysis. Photodiagnosis and
Photodynamic Therapy. 2022;37:102713. DOI:
1016/j.pdpdt.2022.102713
Awadallah M, Idle M, Patel K, Kademani D. Management
update of potentially premalignant oral epithelial lesions. Oral
surgery, oral medicine, oral pathology and oral radiology.
;125(6):628-36. DOI: 10.1016/j.oooo.2018.03.010
Paderno A, Bossi P, Piazza C. Advances in the Multidisciplinary
Management of Oral Cancer. Frontiers in Oncology. 2021;
:817756.doi.org/10.3389/fonc.2021.817756
Lin H-J, Wang X-L, Tian M-Y, Li X-L, Tan H-Z. Betel quid
chewing and oral potential malignant disorders and the impact
of smoking and drinking: A meta-analysis. World Journal of
Clinical Cases. 2022;10(10):3131 doi: 10.12998/wjcc
.v10.i10.3131
Dionne KR, Warnakulasuriya S, Binti Zain R, Cheong SC.
Potentially malignant disorders of the oral cavity: Current
practice and future directions in the clinic and laboratory.
International journal of cancer. 2015;136(3):503-15. DOI:
1055/s-0042-1756663
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