Effects of Myopia on Visual Evoked Potentials in Patients at Tertiary Care Hospital
DOI:
https://doi.org/10.51985/JBUMDC2022106Keywords:
Amplitude, Latency, Myopia, Visual Evoked Potentials, Visual acuityAbstract
bjective: To determine the effects of myopia on Visual Evoked Potentials among the subjects attending the eye OPD.
Study design and setting: This was a cross-sectional study with non-probability convenience sampling technique carried
out at Department of Ophthalmology, Peoples Medical College Hospital Nawabshah / GMMMC Sukkur from March 2021
to November 2021.
Methodology: Total sample size was derived to be 180. Diagnosed myopia irrespective of gender and aged 25 to 45 years
were included. Optic atrophy, Extensive retinal disease, any neurological disorder like multiple sclerosis, stroke and Visual
pathway disorders were excluded. SPSS version 25.0 was used for data analysis.
Results: The mean age of the patients was 39.14 ± 6.73 years. There were n=96 (53%) females and n=84 (47%) males.
In myopic samples the mean pattern stimuli latency P100 in right eye was 92.07 ±5.1 in cases (without correction) and
82.09 ± 5.8 in controls (with correction) with significant P-value 0.023, while in left eye was 93.55 ± 6.7 in cases (without
correction) and 83.6 ± 7.0 in controls (with correction) with significant P-value 0.028.
Conclusion: Greater the myopia; greater was the Visual Evoked Potential (VEP) changes with regards to latency and
amplitude in pattern stimuli especially P100 being the most affected component in this regard. It is therefore necessary
that every patient who goes for VEP test should be corrected for myopic refractive error.
References
Creel DJ. Visually evoked potentials. Handbook of clinical
neurology. 2019; 160: 501-22.
Ito Y, Maehara S, Itoh Y, Matsui A, Hayashi M, Kubo A et
al. Effect of refractive error on visual evoked potentials with
pattern stimulation in dogs. J. Vet. Med. Sci. 2018; 15-0227.
https://doi.org/ 10.1292/jvms.15-0227
Denniston A, Murray P, editors. Oxford handbook of
ophthalmology. OUP Oxford; 2017; 15: 826-9.
Radhika M. Influence of refractive error and ocular dominance
on pattern reversal visual evoked potential: A comparative
study (Doctoral dissertation, Chengalpattu Medical College,
Chengalpattu). 2018.
Kothari R, Bokariya P, Singh S, Narang P, Singh R. Refractive
errors and their effects on visual evoked potentials. Journal
of Clinical Ophthalmology and Research. 2014; 2(1): 3. https://
doi.org/ 10.4103/2320-3897.122625
Lamb TD, Hunt DM. Evolution of the vertebrate
phototransduction cascade activation steps. Dev. Biol.
;431(1):77-92. https://doi.org/ 10.1016/j.ydbio. 2017.03
.018
Astakhova L, Firsov M, Govardovskii V. Activation and
quenching of the phototransduction cascade in retinal cones
as inferred from electrophysiology and mathematical modeling.
Mol. Vis. 2015;21:244-63. PMC4392649
Hashemi H, Fotouhi A, Yekta A, Pakzad R, Ostadimoghaddam
H, Khabazkhoob M. Global and regional estimates of
prevalence of refractive errors: Systematic review and metaanalysis. Journal of current ophthalmology. 2018; 30(1): 3-
https://doi.org/10.1016/j.joco.2017.08.009
Barton JL, Garber JY, Klistorner A, Barnett MH. The
electrophysiological assessment of visual function in Multiple
Sclerosis. Clinical neurophysiology practice. 2019; 4: 90-6.
https://doi.org/10.1016/j.cnp.2019.03.002
Jiang TT, Wang L, Chen HL, Deng Y, Peng XL, Hu Y.
Developmental characteristics of visual evoked potentials to
different stimulation in normal children. International Journal
of Neuroscience. 2021; 3: 1-11. https://doi.org/ 10.1080/
2021.1912039
Gupta CK, Ranabhat S, Roy R. Effect of Refractive Error on
Visual Evoked Potential in Myopic Males and Females. Acta
Scientific Ophthalmology. 2021; 4(1): 22-26.
Li X, Friedman IB, Medow NB, Zhang C. Update on
orthokeratology in managing progressive myopia in children:
efficacy, mechanisms, and concerns. Journal of pediatric
ophthalmology and strabismus. 2020; 54(3):142-8.
https://doi.org/ 10.3928/01913913-20170106-01
Thabit MN, Farouk MM, Awni M, Mohamed AA. Early
disability in ambulatory patients with multiple sclerosis:
optical coherence tomography versus visual evoked potentials,
a comparative study. The Egyptian Journal of Neurology,
Psychiatry and Neurosurgery. 2020; 56(70):1-9. https:// doi.
org/10.1186/s41983-020-00204-0
Jha AT, Yousuf PS, Gupta SB. Effect of Myopia on Visual
Evoked Potential. IOSR Journal of Dental and Medical
Sciences (IOSR-JDMS). 2015; 14 (4): 49-52. https://doi.
org/10.9790/0853-14474952
Agrawal A, Puthalath AS, Mittal SK, Mittal S, Singh Y, Singh
A. Alteration in pattern reversal visual evoked potential in
pediatric population with amblyopia and spherical refractive
errors. Indian Journal of Ophthalmology. 2022; 70(5): 1727-
https://doi.org/10.4103/ijo.IJO_2692_21.
Evans AB. (2022) Clinical Utility of Evoked Potentials
(Medscape). https://emedicine.medscape.com/article/1137451-
overview. Accessed date: 29th June, 2022.
Hamilton R, Bach M, Heinrich SP, Hoffmann MB, Odom JV,
McCulloch DL et al. VEP estimation of visual acuity: a
systematic review. Documenta Ophthalmologica. 2021;
(1):25-74. https://doi.org/10.1007/s10633-020-09770-3
Zheng X, Xu G, Zhang K, Liang R, Yan W, Tian P et al.
Assessment of Human Visual Acuity Using Visual Evoked
Potential: A Review. Sensors. 2020; 20 (5542): 1-26. https://doi.
org/10.3390/s20195542
Hemptinne C, Liu-Shuang J, Yuksel D, Rossion B. Rapid
objective assessment of contrast sensitivity and visual acuity
with sweep visual evoked potentials and an extended electrode
array. Investigative ophthalmology & visual science. 2018;
(2): 1144-57. doi:https://doi.org/10.1167/iovs.17-23248
Misra UK, Kalita J. Clinical neurophysiology: nerve
conduction, electromyography, evoked potentials. (4th Edition)
Published by Elsevier. https://www.elsevier. com/books/
clinical-neurophysiology/misra/978-81-312-5815-6. Accessed
Date: 29-6-2022
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Abdul Haleem Mirani , Amjad Ali, Ataullah Bukhari, Tehmina Imdad, Ateeq Ur Rehman Channa, Maqbool Ahmed Jamali
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Journal of Bahria University Medical & Dental College is an open access journal and is licensed under CC BY-NC 4.0. which permits unrestricted non commercial use, distribution and reproduction in any medium, provided the original work is properly cited. To view a copy of this license, visit https://creativecommons.org/licenses/by-nc/4.0