Abstract:
Objective: To study the risk factors, complications and use of streptokinase in patients of acute myocardial infarction (MI) presenting at Coronary Care Unit (CCU) of PNS SHIFA Hospital Karachi. Materials and Methods: This study was conducted at CCU, PNS SHIFA Hospital Karachi, from January 2008 to December 2012. It is a retrospective cohort study with non-probability convenient sampling. Diagnosed MI cases were included in the study from all age groups, gender and backgrounds. Patients with other cardiac/non-cardiac diseases presenting with symptoms similar to MI were excluded. Results: Acute myocardial infarction patients were 418, out of the total 2250 admissions in CCU, 71.29% were males. 67.7% were smokers, 60.2% had sedentary life style, 56.2% patients were known hypertensive and 42.1% were known diabetics. 63.63% were eligible for streptokinase administration at the time of admission. Left ventricular failure developed in 13% patients and 6.6% went into cardiogenic shock. Conclusion: Acute myocardial infarction was found to be fairly common cardiac emergency among all cases admitted in the CCU. It has strong association with male gender, smoking, sedentary life style, hypertension, diabetes mellitus and hyperlipidemia. Left Ventricular failure was the leading complication. 63.63% were eligible for streptokinase administration and mortality rate was 5%.