Abstract:
Objective: It has been observed that non-invasive ventilation used in premature with Respiratory distress syndrome and
notably decrease level of partial pressure of carbon-dioxide (PaCO2) level in blood. The primary goal of this study was
to assess the effect of non-invasive ventilation in decreasing the level of partial pressure of carbon dioxide (PaCO2) level
and supplementary oxygen need in premature neonates with RDS.
Study Design and Settings: This randomized controlled trial was done in Jan 2021 till August 2021 at PNS SHIFA Karachi.
Methodology: Neonates with gestational age (GA <34 wk) with RDS at birth were randomly assigned to nasal intermittent
positive pressure ventilation (NIPPV) and nasal high frequency oscillatory ventilation (NHFOV) for respiratory support
after giving surfactant .Twenty three preterm babies were included in each group .Level of partial pressure of carbon dioxide
at 2hrs and 24hrs of non-invasive ventilation and supplementary oxygen need was evaluated.
Results: Non-invasive ventilation was found to reduce the PaCO2 level (p= .01), NIPPV (43.06±13.74) vs. (33.63±19.99)
in NHFOV at 2hrs and 24hrs NIPPV (19.89±7.18) vs. NHFOV (14.04±8.39).Value of pH was also significant in two groups
with optimal mean airway pressure. Supplementary oxygen period were also reduced in NHFOV than NIPPV group (35.7%
vs. 64.3%).
Conclusion: NHFOV was a beneficial mode in maintaining level of pH, PaCO2 level and reducing need of supplementary
oxygen in preterm babies with RDS