Abstract:
Objective: To investigate the association of resistin with components of metabolic syndrome (MetS) in our local population.
Study design & setting: Case-control study, Medical OPD; Lyari General Hospital Karachi (from 15th July 2020 till 15th
December 2020).
Methodology: A total of 164 subjects (83 cases & 81 controls) between the age ranges of 35-65 years were selected.
Subjects with metabolic syndrome were included in concordance with International Diabetes Federation criteria. Serum
resistin levels in both cases and controls were compared. SPSS 20 was used for statistical analysis. Eighty-three patients
with metabolic syndrome were enrolled and compared with 81 healthy unmatched controls. Obesity indices, blood pressure,
lipid profile, fasting blood sugar, insulin resistance and serum resistin levels were evaluated. Predictive values of resistin
for MetS were analyzed using odds ratios.
Results: Significantly elevated levels of resistin were found in subjects with metabolic syndrome compared to healthy
controls (8.23±4.43 vs 6.82±3.64 ng/mL, p<0.05). The odds ratio (95% confidence interval) for metabolic syndrome in
subjects having higher resistin were: males:2.62[1.11–6.19], females: 2.81[1.05–7.49], all Ptrend<0.05.For individual
components of metabolic syndrome, we found the odds ratio to be greatest for hypertension, fasting blood sugar, and insulin
resistance; 2.64, 4.83, 2.85, respectively, all Ptrend<0.05.
Conclusion: The present study suggests significant association of resistin with components of metabolic syndrome such
as hypertension, fasting blood sugar, and insulin resistance. Compared to healthy controls, subjects with MetS had significantly
higher resistin levels. Further research is required to incorporate this biomarker in clinical setting.