Protective Effects Of Tecomella Undulata Stem Bark Extract On Isoniazid Induced Hepatotoxicity: Based On Liver Enzymes And Histopathology In Rat Model
Issue Details
| Journal ID | 1 |
|---|---|
| Volume | 10 |
| Number | 1 |
| Year | 2020 |
| Issue Date | 2021-07-29 01:20:36 |
| DOI | 10.51985/JBUMDC2019124 |
| Copyright Holder | Zubaida Umar Zehri, Shabih Zehra, Abdul Lateef Mahesar, M. Anwar, Syed Ijaz Hussain Zaidi, M. Ashraf |
| Copyright Year | 2020 |
Keywords:
Abstract:
Objective: To evaluate the hepatoprotective effects of Tecomellaundulata stem bark extract on isoniazid induced hepatic
damage based on liver enzymes and Liver function test in rat models.
Study design and Setting: An experimental study conducted at Department of Pharmacology at Al-Tibri Medical College
and Hospital, Isra University Karachi Campus and Dow University of Health Sciences, Karachi.
Methodology: Total twenty-four rats were studied. The albino rats that were male, healthy, and weighing 200-250grams
were included in this study. Rats were divided into four groups, each group having six rats and treated once daily orally
for 30 days. Group A was control group and treated with normal animal diet and water; Group B was Isoniazid treated
group and induced by oral administration of Isoniazid (INH) 50mg/kg. Group C was treated with Isoniazid 50mg/kg and
Tecomellaundulata bark extract with low dose of 200mg/kg . Group D was treated with Isoniazid 50mg/kg and
Tecomellaundulata bark extract with high dose of 400mg/kg . All the animals were weighed before commencement of the
study. Liver enzymes were noted after the end of experiment. P value of <0.05 was taken as significant.
Results: While comparing the mean values of AST,ALT, ALP and GGT in all four groups group; the statistical significant
difference (p<0.001) was found. The mean levels in of total Bilirubin in group A was 0.69 ±0.01, group B 1.04 ±0.04, in
group C was 1.15 ±0.39, and in group D was 1.04 ±0.44 with the significant difference (p=0.004).
Conclusion: Tecomellaundulata has a protective effect on isoniazid induced toxicity on liver as evidenced by liver function
test on rat models.
Objective: To evaluate the hepatoprotective effects of Tecomellaundulata stem bark extract on isoniazid induced hepatic
damage based on liver enzymes and Liver function test in rat models.
Study design and Setting: An experimental study conducted at Department of Pharmacology at Al-Tibri Medical College
and Hospital, Isra University Karachi Campus and Dow University of Health Sciences, Karachi.
Methodology: Total twenty-four rats were studied. The albino rats that were male, healthy, and weighing 200-250grams
were included in this study. Rats were divided into four groups, each group having six rats and treated once daily orally
for 30 days. Group A was control group and treated with normal animal diet and water; Group B was Isoniazid treated
group and induced by oral administration of Isoniazid (INH) 50mg/kg. Group C was treated with Isoniazid 50mg/kg and
Tecomellaundulata bark extract with low dose of 200mg/kg . Group D was treated with Isoniazid 50mg/kg and
Tecomellaundulata bark extract with high dose of 400mg/kg . All the animals were weighed before commencement of the
study. Liver enzymes were noted after the end of experiment. P value of <0.05 was taken as significant.
Results: While comparing the mean values of AST,ALT, ALP and GGT in all four groups group; the statistical significant
difference (p<0.001) was found. The mean levels in of total Bilirubin in group A was 0.69 ±0.01, group B 1.04 ±0.04, in
group C was 1.15 ±0.39, and in group D was 1.04 ±0.44 with the significant difference (p=0.004).
Conclusion: Tecomellaundulata has a protective effect on isoniazid induced toxicity on liver as evidenced by liver function
test on rat models.
Published: 2021-03-17
Last Modified: 2022-02-18 06:05:42