Abstract:
Objective: To evaluate effect of Withania coagulans and liraglutide on serum Glucagon like peptide-1, Postprandial and
Fasting Blood Glucose levels in streptozotocin induced diabetic rat.
Study Design and Setting: This randomize control trile was conducted at Islamic International Medical College in
collaboration with National Institute of Health Islamabad.
Methodology: This randomized controlled study was performed on a total of forty male Sprague dawly rats, which were
initially divided into two groups; Group A (n=10) and Experimental Group (n=30). Diabetes in the Experimental group B
was induced by intraperitoneal administration of streptozotocin for 5 days (30mg/kg/day). Diabetes was checked in
experimental group by measuring fasting blood glucose (mg/dl) on day 6. Experimental group was further divided into
Group B (Diabetic control), Group C (Withania coagulans-treated) and Group D (Liraglutide-treated). Blood sampling was
done at day 30 and serum GLP-1, postprandial and fasting blood glucose levels were measured and compared in all groups.
Results: Fasting and postprandial blood glucose levels of group C and D were significantly reduced as compared to group
B. Serum GLP-1 levels were significantly increased in group C and D as compared to group B.
Conclusion: Withania coagulans reduces hyperglycemia in diabetic rats through increasing GLP-1 hormone.