Abstract:
Objective: To observe the effect of Citrullus lanatus var. lanatus on albino mice model of anxiety and depression.
Methodology: This experimental study was done in the Pharmacology department of Karachi University for a period of 02
months from 5th February-9th April 2016. Watermelon (Citrullus lanatus var. lanatus) was used. Animals were randomly assigned
into 4 groups A, B, C and D (n=10). Group A was control (normal saline). Group B was treated with Citrullus lanatus juice in
a dose of 3 ml/kg, Group C was given 6 ml/kg of juice. Two drugs (Diazepam and Fluxetin) were used as standard and given
to group D animals. All doses were administered orally. Level of anxiety and depression among animals was tested by light/dark
box test and forced swim test. Data was analyzed statistically.
Results: Animals treated with Citrullus lanatus juice showed marked reduction in anxiety which was evident from results of
light/dark box test while forced swim test revealed no effect on depression.
Conclusion: Citrullus lanatus contains important natural anti-oxidants like lycopene and vitamin C which prevent injury to
vital organs like liver, heart and brain from toxic effects of reactive oxygen species. Arginine in Citrullus juice is also precursor
of neurotransmitters like -Aminobutyric acid (GABA) and glutamate. These results showed that Citrullus because of its
components like arginine played an important role in maintaining normal neurological function and ameliorated anxiety and
depression.