TY - JOUR AU - Maqbool, Muhammad Salman PY - 2022/04/01 Y2 - 2024/03/28 TI - Efficacy of Prophylactic Phenylephrine in Prevention of Hypotension in Parturient Undergoing Spinal Caesarean Section JF - Journal of Bahria University Medical and Dental College JA - J. Bahria Univ. Med. Dent. Coll. VL - 12 IS - 02 SE - Original Articles DO - 10.51985/JBUMDC2021113 UR - https://jbumdc.bahria.edu.pk/index.php/ojs/article/view/869 SP - 93-99 AB - <p><span class="fontstyle0">OBJECTIVE:<br></span><span class="fontstyle1">To determine the hemodynamic (pulse, blood pressure) stability of prophylactic bolus dose of phenylephrine in caesarean<br>section under spinal anaesthesia.<br></span><span class="fontstyle0">Study design &amp; Setting: </span><span class="fontstyle1">Interventional study was done from 13</span><span class="fontstyle1">th </span><span class="fontstyle1">Feb 2021 to 07</span><span class="fontstyle1">th </span><span class="fontstyle1">Oct 2021 at Islam Teaching Hospital,<br>Sialkot.<br></span><span class="fontstyle0">Methodology: </span><span class="fontstyle1">Study approval was taken vide letter no.2021-05/AN dated 26-3-2021, issued by Chairman Ethical Review<br>Board, Islam Medical College, Sialkot. Statistical software(version.3.1.9.2) with (prob of 0.80, critical </span><span class="fontstyle1">2 </span><span class="fontstyle1">value 15.08),<br>was employed and sample size calculated to be 200 cases i.e. groups-I (injection phenylephrine 100µgm) and group-II<br>(placebo) divided by lottery method into 100 each given at spinal neuraxial block. Primary study variable being heart rate<br>and blood pressure variations. Spearman’s Rank correlation statistical test was used to check interdependence between the<br>two variables i.e., systolic blood pressure and pulse rate. SPSS version 21 was used.<br></span><span class="fontstyle0">Results</span><span class="fontstyle1">: In group-II, in 36% cases atropine was given as compared to 24% cases in group-I, thus 150 % more anti-cholinergic<br>was used in group-II. In group-II, in 33% cases top-up of injection Adrenaline 10 microgram was used whereas given in<br>24% cases in group-I, thus 137.5 % more top-ups of vasopressors in group-II. In group-I, heart rate decreased by value<br>of 9.02 % with respect to baseline value, while comparable reading noted was 3.42% decline in pulse rate in group-II<br>respectively.<br></span><span class="fontstyle0">Conclusion</span><span class="fontstyle1">: Prophylactic phenylephrine at time of spinal injection resulted in stable blood pressure and pulse rate values<br>in caesarean spinal delivery.</span> </p> ER -