@article{Ali_Mahmud_2022, title={Use of Non-Invasive Ventilation in Reducing Partial Pressure of Carbon Dioxide Level (Paco2) in Neonates with Respiratory Distress Syndrome}, volume={12}, url={https://jbumdc.bahria.edu.pk/index.php/ojs/article/view/948}, DOI={10.51985/JBUMDC2021106}, abstractNote={<p><span class="fontstyle0">Objective: </span><span class="fontstyle2">It has been observed that non-invasive ventilation used in premature with Respiratory distress syndrome and<br>notably decrease level of partial pressure of carbon-dioxide (PaCO2) level in blood. The primary goal of this study was<br>to assess the effect of non-invasive ventilation in decreasing the level of partial pressure of carbon dioxide (PaCO2) level<br>and supplementary oxygen need in premature neonates with RDS.<br></span><span class="fontstyle0">Study Design and Settings: </span><span class="fontstyle2">This randomized controlled trial was done in Jan 2021 till August 2021 at PNS SHIFA Karachi.<br></span><span class="fontstyle0">Methodology: </span><span class="fontstyle2">Neonates with gestational age (GA <34 wk) with RDS at birth were randomly assigned to nasal intermittent<br>positive pressure ventilation (NIPPV) and nasal high frequency oscillatory ventilation (NHFOV) for respiratory support<br>after giving surfactant .Twenty three preterm babies were included in each group .Level of partial pressure of carbon dioxide<br>at 2hrs and 24hrs of non-invasive ventilation and supplementary oxygen need was evaluated.<br></span><span class="fontstyle0">Results: </span><span class="fontstyle2">Non-invasive ventilation was found to reduce the PaCO2 level (p= .01), NIPPV (43.06±13.74) vs. (33.63±19.99)<br>in NHFOV at 2hrs and 24hrs NIPPV (19.89±7.18) vs. NHFOV (14.04±8.39).Value of pH was also significant in two groups<br>with optimal mean airway pressure. Supplementary oxygen period were also reduced in NHFOV than NIPPV group (35.7%<br>vs. 64.3%).<br></span><span class="fontstyle0">Conclusion: </span><span class="fontstyle2">NHFOV was a beneficial mode in maintaining level of pH, PaCO2 level and reducing need of supplementary<br>oxygen in preterm babies with RDS</span> </p>}, number={03}, journal={Journal of Bahria University Medical and Dental College}, author={Ali, Rida and Mahmud, Shahid}, year={2022}, month={Jul.}, pages={148–151} }