Toxic Effects Of Corn Oil On Liver Histology In Albino Rats

Authors

  • Aisha Qamar
  • Humera Waqar
  • Asma Siddiqui
  • Hemant Kumar
  • Mohammad Saad Saeeduddin

Keywords:

High-corn oil diet, Fatty liver, Steatohepatitis, Metabolic Syndrome

Abstract

Objective: To evaluate whether high quantities of unsaturated fats such as corn oil can produce fatty liver in albino rats. Materials and Methods: This experimental study was carried out at BMSI, JPMC after obtaining ethical approval, from October to November 2008. Forty adult albino rats, weighing 200 to 240 grams were divided into 2 groups according to dietary regimen. Group A received control diet and Group B received high-corn oil diet (20 ml corn oil in 100 gm of diet).The groups were further divided into A1, A2 and B1, B2 on the basis of duration of treatment, that is 4 weeks and 8 weeks respectively. The rats were sacrificed, liver removed and processed for haematoxylin and eosin staining. Results: Haematoxylin and eosin stained sections revealed swollen hepatocytes having vesicular appearance with absent or pyknotic nuclei in high-corn oil group as compared to control animals. Conclusion: This study has proved that use of high quantities of unsaturated fats, such as corn oil can lead to fatty liver. 

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Published

2015-03-03

How to Cite

Qamar, A. ., Waqar, H. ., Siddiqui, A. ., Kumar, H. ., & Saeeduddin, . M. S. . (2015). Toxic Effects Of Corn Oil On Liver Histology In Albino Rats. Journal of Bahria University Medical and Dental College, 5(1), 25–28. Retrieved from https://jbumdc.bahria.edu.pk/index.php/ojs/article/view/99

Issue

Vol. 5 No. 1 (2015): Volume 5 issue 1

Section

Original Articles

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Copyright (c) 2015 Aisha Qamar, Humera Waqar, Asma Siddiqui, Hemant Kumar, Mohammad Saad Saeeduddin

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