Effect of Raphanus Sativus (Radish) Leaf Extract on Atorvastatin Induced Hepatotoxicity in Rabbits

Authors

  • Obaid Anwar
  • Mazhar Iqbal
  • Sadia Chiragh
  • Owais bin Qadeer Gill
  • Muhammad Iqbal

DOI:

https://doi.org/10.51985/JBUMDC2018062

Abstract

Objectives: To investigate hepato-protective effect of ethanolic leave extract of Raphanus sativus against atorvastatin
induced hepatotoxicity in albino rabbits.
Study design: Experimental study
Material and Method: This study conducted at department of Physiology and Pharmacology, University of Agriculture,
Faisalabad. The ethanolic extract of Raphanus sativus was prepared for hepatoprotective effect against hepatotoxicity
produced by atorvastatin.
Results: The results were compared with normal and experimental control. Serum was tested for ALT, AST, Alkaline
Phosphatase and Bilirubin along with histological studies. Ethanolic extract of Raphanus sativus with 100mg/kg. of body
weight dosage developed some changes representing hepatotoxicity but higher doses showed an increase in toxicity as
observed on histologic sections. A reduction in fibrosis and cholestasis was observed which needs further evaluation.
Conclusion: Ethanolic extract of raphanus sativus did not show any amelioration in the increased enzymes level however
a reduction in cholestasis was observed as represented by decreases in alkaline phosphatase levels also confirmed by
histological studies.

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Published

2021-03-22

How to Cite

Obaid Anwar, Mazhar Iqbal, Sadia Chiragh, Owais bin Qadeer Gill, & Muhammad Iqbal. (2021). Effect of Raphanus Sativus (Radish) Leaf Extract on Atorvastatin Induced Hepatotoxicity in Rabbits. Journal of Bahria University Medical and Dental College, 8(4), 204–209. https://doi.org/10.51985/JBUMDC2018062

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Original Articles