Effect of Raphanus Sativus (Radish) Leaf Extract on Atorvastatin Induced Hepatotoxicity in Rabbits
DOI:
https://doi.org/10.51985/JBUMDC2018062Abstract
Objectives: To investigate hepato-protective effect of ethanolic leave extract of Raphanus sativus against atorvastatin
induced hepatotoxicity in albino rabbits.
Study design: Experimental study
Material and Method: This study conducted at department of Physiology and Pharmacology, University of Agriculture,
Faisalabad. The ethanolic extract of Raphanus sativus was prepared for hepatoprotective effect against hepatotoxicity
produced by atorvastatin.
Results: The results were compared with normal and experimental control. Serum was tested for ALT, AST, Alkaline
Phosphatase and Bilirubin along with histological studies. Ethanolic extract of Raphanus sativus with 100mg/kg. of body
weight dosage developed some changes representing hepatotoxicity but higher doses showed an increase in toxicity as
observed on histologic sections. A reduction in fibrosis and cholestasis was observed which needs further evaluation.
Conclusion: Ethanolic extract of raphanus sativus did not show any amelioration in the increased enzymes level however
a reduction in cholestasis was observed as represented by decreases in alkaline phosphatase levels also confirmed by
histological studies.
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Copyright (c) 2018 Obaid Anwar; Mazhar Iqbal, Sadia Chiragh, Owais bin Qadeer Gill, Muhammad Iqbal
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Journal of Bahria University Medical & Dental College is an open access journal and is licensed under CC BY-NC 4.0. which permits unrestricted non commercial use, distribution and reproduction in any medium, provided the original work is properly cited. To view a copy of this license, visit https://creativecommons.org/licenses/by-nc/4.0