Abstract:
Schizophrenia is a disorder of mental debility characterized by abnormal social behavior in which person is unable to
recognize reality. The sign and symptoms are variable and heterogeneous. Due to the diverse symptoms and variable
treatment response, it is challenging to treat. Recent advancements in genomic, epidemiology and neurosciences can
provide the appropriate medicines and treatments for minimizing symptoms and consequences of schizophrenia. This
literature review was highlights the etiology, pathophysiology, neurotransmitter system, novel treatment and management
of schizophrenia.The mainstay treatment of schizophrenic patients included antipsychotic drug with psychotherapy, social
rehabilitation and job training.