Evaluation Of Weight Changes On Wistar Rats Induced By Erythromycin And Aqueous Neem Leaves Extract
DOI:
https://doi.org/10.51985/JBUMDC2018088Keywords:
Erythromycin, Hepatotoxicity, Azadirachta indica (Neem).Abstract
Objective: To evaluate weight changes on the liver of male (albino wistar) rats induced by erythromycin. To assess the
outcome of aqueous Neem leaf extract on erythromycin induced hepatic injuries.
Methodology: Eighty male albino wistar rats were taken randomly and were divided into 4 groups of 20 animals each.
Group A as a control group. Group B rats were treated with erythromycin drug. Group C rats were treated with erythromycin
along with Aqueous Neem leaves extract. Group D were given only Aqueous Neem leaves extract. Body weight of animals
was recorded initially and also after experimentation. After 14 days animals were sacrificed, liver weight was also recorded.
Results: The liver of erythromycin treated animals group B were little bigger in size and more reddish. However erythromycin
plus Neem treated animals of group C livers were almost like liver of control group A and only Neem given group D
animals, liver were exactly same appearance like control group A.Rise in absolute and relative weight of liver was because
of drug toxicity.
Conclusion: Its established from this recent study that Aqueous Neem leaves extract being a powerful antioxidant, decreased
oxidative stress and hepatic injury caused by erythromycin
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