Prevalence of Hypocalcemia in Infants of Mothers with Gestational Diabetes
DOI:
https://doi.org/10.51985/JBUMDC2024419Keywords:
Hypocalcemia, Infants, Gestational Diabetes, Maternal HyperglycemiaAbstract
Objective: To evaluate the prevalence of newborn hypocalcemia among infants of mothers with gestational diabetes. Study Design & Setting: This cross-sectional study was conducted at PNS Shifa Hospital, Karachi, from November 2023 to March 2024
Methodology: Each mother's fasting blood sugar level was evaluated by drawing 5 ml of blood. At 24 hours after delivery, sterile blood samples (2 cc) were taken to determine the neonate's calcium level; a serum calcium level below 7 mg/dl was regarded as hypocalcemia. All information was gathered using a research template that was created in-house. Serum calcium was measured using the Arsenazo III method, and serum albumin was assessed using the bromocresol green (BCG) method.
Results: The mean ± S.D. of the maternal age of the study participants was 26.83 ± 3.87 years. The mean ± S.D. of the gestational age of the study participants was 37.35 ± 0.86 weeks. The mean ± S.D. of fasting glucose levels of the study participants was 104.5 ± 15.1 mg/dl. A total of 27.5% of infants born to mothers with gestational diabetes had hypocalcemia. Infants' median Apgar scores at 1 and 5 minutes were 6 and 9, respectively. The prevalence of hypocalcemia in newborns was highest among mothers aged 21–30, though this difference was not statistically significant (p = 0.139).
Conclusion: The results showed that 27.5% of infants born to mothers with gestational diabetes had hypocalcemia. Maternal age did not have a statistically significant association with hypocalcemia in newborns.
References
1. Sabzehei MK, Otogara M, Ahmadi S, Daneshvar F, Shabani
M, Samavati S, et al. Prevalence of hypoglycemia and
hypocalcemia among high-risk infants in the neonatal ward
of Fatemieh Hospital of Hamadan in 2016-2017. Hormozgan
Med J. 2020;24(1).DOI: 10.5812/hmj.94453.
2. Awan NN, Abbas S, Naz M, Jameel M, Iftikhar S. Frequency
of Hypocalcemia in Infants of Diabetic Mothers within 24
Hours of Life. Pak J Med Health Sci. 2023;17(02):586. DOI:
10.53350/pjmhs2023172586.
3. Shah SB, Bawar S, Farooq N. Common Complications in
Infants Born to Diabetic Mothers: Complications in Infants
Born to Diabetic Mothers. Pak J Health Sci. 2024:84-9. DOI:
10.54393/pjhs.v5i1.973
4. Islam MM, Ahmmad BN, Karim MR, Islam MR, Uddin MB,
Hoque MS. Glucose and Calcium Profile in Infants of Diabetic
and Nondiabetic Mothers-A Comparative Study. TAJ: Journal
of Teachers Association. 2022;35(2):93-102. DOI:
10.3329/taj.v35i2.58600.
5. Kavitha R, Vanitha R. A Study of Incidence of Hypoglycaemia
and Hypocalcaemia in Infants Born to Diabetic Mothers and
a Correlation with Maternal Third Trimester Glycaemic
Control. J Clin Diagn Res. 2020;14(3). DOI: 10.7860/JCDR
/2020/42574.13589.
6. Suda-Ca³us M, D¹browska K, Gulczyñska E. Infant of a
diabetic mother: clinical presentation, diagnosis and treatment.
Pediatr Endocrinol Diabetes Metab. 2024;30(1):36-41. DOI:
10.5114/pedm.2024.127360.
7. Raghuveer G, BhanuPrakash BP, Reddy GC, Mahati M.
Morbidity Profile of Neonates Born to Diabetic Mothers in
a Rural Tertiary Care Hospital. Int J Acad Med Pharm.
2023;5(3):465-72. DOI: 10.46939/ijamp.v5i3.130.
8. Vuralli D. Clinical approach to hypocalcemia in newborn
period and infancy: who should be treated? Int J Pediatr.
2019;2019. DOI: 10.1155/2019/4318075.
9. Patra D, Jena PK, Murmu MC, Swain B, Bhat S. Outcome
of Infants Born to Diabetic Mother in a Tertiary Care Hospital.
DOI: (DOI not available).
10. Stewart A, Malhotra A. Gestational diabetes and the neonate:
challenges and solutions. Res Rep Neonatol. 2015;5:31-9.
DOI: 10.2147/RRN.S61559.
11. Toor KM, Wahid S, Azeem K. Frequency of Metabolic
Complications in Infants Born to Diabetic Mothers at KRL
Hospital, Islamabad. J Islamabad Med Dent Coll. 2015;4(1):23-
6. DOI: 10.35787/jimdc.v4i1.73.
12. Ostlund I, Hanson U, Bjorklund A, Hjertberg R, Eva N,
Nordlander E, et al. Maternal and fetal outcomes if gestational
impaired glucose tolerance is not treated. Diabetes Care. 2003;
26(7):2107-11. DOI: 10.2337/diacare.26.7.2107.
13. Peters S, Andrews C, Sen S. Care of infants born to women
with diabetes. Curr Diab Rep. 2020;20:1-4. DOI: 10.1007/
s11892-020-01321-5.
14. Bhavya SO, Ranitha R. Early predictors of early onset neonatal
hypocalcaemia in infants of diabetic mother. Int J Contemp
Pediatr. 2019;6:1325-9. DOI: 10.18203/2349-3291.ijcp2019
2739.
15. Ashokkumar H, Natesh S, Mohammed S. Cord blood HbA1c
and neonatal outcomes in infants of diabetic mothers in a
tertiary care hospital. Rom J Diabetes Nutr Metab Dis.
2024;31(1):928-41. DOI: 10.46389/rjd-2024-1389.
16. Sonia SF, Haque MF, Parvin R, Sultana A, Afroze S, Hassan
MS. Metabolic and haematological profile of infants born to
gestational and pregestational diabetic mothers. Bangladesh
J Child Health. 2020;44(2):82-6. DOI: 10.3329/bjch.v44i2.
52908.
17. Almhanna MG, Easa ZO, Alatwani SH. Morbidity and
mortality among infants of diabetic mothers admitted to a
neonatal care unit in Karbala pediatric teaching hospital. J
Med Life. 2022;15(8):994. DOI: 10.25122/jml-2022-0014.
18. Radwan MA, El Mansori NA, Elfergani MA, Halies FR,
Lawgali MA. Neonatal Morbidity Pattern among Infants Born
to Diabetic Mothers at Jamhouria Hospital, Benghazi-Libya.
Asian J Pediatr Res. 2021;7(4):38-55. DOI: 10.9734/ajpr/
2021/v7i430258.
19. Bhatta M, Aneja V. Morbidities and its Immediate Outcome
in Newborns Born Through Mothers with Gestational Diabetes
Mellitus. Nepal J Health Sci. 2022;2(1):72-9. DOI: 10.3126/
njhs.v2i1.47169.
20. Ðukiæ E, Milas D, Prutki A, Nað T, Arambašiæ M, Milas V.
Comparison of the Neonatal Outcome in Mothers with
Gestational Diabetes (GD) in Two Periods. Coll Antropol.
2020;44(1):29-36. DOI: 10.5671/ca.44.1.5.
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