Lipid Profile Abnormalities in ß-Thalassemia Patients with Multiple Blood Transfusions
DOI:
https://doi.org/10.51985/JBUMDC2022160Keywords:
Atherosclerosis, Blood transfusion, Iron overload, Lipid profile, ß-ThalassemiaAbstract
Objective: To determine lipid profile abnormalities in ß -thalassemia patients with multiple blood transfusions in tertiary care hospital.
Study design and setting: This cross-sectional study was conducted in Chemical Pathology section, Pathology department Sheikh Zayad Medical College and Hospital Rahim Yar Khan from 1st July 2022 to 31st October 2022.
Methodology: 110 patients aged 1 to 18 years from both genders enrolled in Thalassemia center of Sheikh Zayed Hospital with multiple blood transfusions were included in study using convenient sampling technique. Patients with cardiac disease, diabetes mellitus and family history of lipid disorders were excluded. Blood samples collected from thalassemia patients were subjected to estimation of serum total cholesterol, serum triglycerides, HDL-C, and LDL-C. Data was recorded on predesigned performa. Post stratification t test was applied and p value <0.05 was considered significant.
Results: Mean age of the patients was 7.77±3.846 years. Mean serum cholesterol, serum triglyceride, HDL-C and LDLC were 89.15±20.33mg/dl, 211.00±77.78mg/dl, 21.01±6.554mg/dl and 29.79±17.02 respectively. Mean triglyceride and LDL-C level was higher in patients with weekly transfusion than patients undergoing monthly transfusion with statistically significant difference of triglycerides and LDL-C between two groups with p=0.002 and 0.023 respectively. Conclusion: We found that frequent blood transfusion causes lipid profile abnormalities in thalassemia patients. Lipid profile abnormalities should be screened frequently in ß-thalassamia patients with multiple blood transfusions.
References
Ragab SM, Safan MA, Sherif AS. Lipid profiles in ß
thalassemic children. Menoufia Med J 2014; 27(1):66 DOI:
https://doi.org/10.4103/1110-2098.132749
Suman R, Sanadhya A, Meena P, Singh J, Jain R, Meena S.
Lipid profile in children of ß-thalassemia mayor and their
correlation with serum ferritin. Int J Contemp Pediatr 2017
Mar; 4(2):543-7
Origa R. ß-Thalassemia. Genet Med 2017 ;19(6):609-19 DOI:
https://doi.org/10.1038/gim.2016.173
Ali S, Mumtaz S, Shakir HA, Khan M, Tahir HM, Mumtaz
S, et al. Current status of beta-thalassemia and its treatment
strategies. Mol Genet Genomic Med 2021;9(12):e1788 DOI:
https://doi.org/10.1002/mgg3.1788
Akhtar S, Nasir JA, Hinde A. The prevalence of hepatitis C
virus infection in ß-thalassemia patients in Pakistan: a
systematic review and meta-analysis. BMC Public Health
; 20(1):1-9 DOI: https://doi.org/10.1186/s12889-020-
-5
Wibowo TS, Ashariati A, Bintoro S, Soeslistijo SA. Serum
Ferritin Levels and Lipid Profile in Patients with TransfusionDependent Beta and Beta/HbE Thalassemia. Int J Pharm Res
; 12(4)
Balcý YI, Ünak Þ, Gümrük F. Serum Lipids in Turkish Patients
with ß-Thalassemia Major and ß-Thalassemia Minor. Turk J
Hematol 2016; 33:71-83
Maira D, Cassinerio E, Marcon A, Mancarella M, Fraquelli
M, Pedrotti P, et al. Progression of liver fibrosis can be
controlled by adequate chelation in transfusion-dependent
thalassemia (TDT). Ann Hematol 2017;96:1931-6 DOI:
https://doi.org/10.1007/s00277-017-3120-9
Taher AT, Saliba AN. Iron overload in thalassemia: different
organs at different rates. Hematology Am Soc Hematol Educ
Program 2017; 2017(1):265-71 DOI: https://doi.org/10.1182
/asheducation-2017.1.265
Nandi S, Samanta S, Mondal T, Halder S. Study of lipid
profile in ß thalassemia major pediatric patients with multiple
blood transfusion and its correlation with serum ferritin level
in tertiary care hospital in Kolkata. Int J Community Med
Public Health 2021; 8(4):1778 DOI: https://dx.doi.org/
18203/ 2394-6040.ijcmph20211233
Jabbar HK, Hassan MK, Al-Naama LM. Lipids profile in
children and adolescents with ß-thalassemia major. Hematol
Transfus Cell Ther 2022 DOI: https://doi.org/10. 1016/
j.htct.2022.09.1277
Saleh KK, Abdullah SR, Mekha RE. Estimation of Serum
Homeostasis Model Assessment-Insulin Resistance and Lipid
Profile in Beta-thalassemia Major Patients and their Correlation
with Iron Overload in Koya City. Polytechnic J 2019; 9(2):125-
DOI: https://doi.org/10.25156/ptj.v9n2y2019.pp125-132
Daswani P, Garg K. Lipid profile in?-thalassemia major
children and its correlation with various parameters. Indian
J Child Health 2021; 8(1):26-31 DOI: https://doi.org/10.32677
/IJCH.2021.v08.i01.005
Kumar T, Basu S, Kundu R, Majumdar I, Mukherjee D. Lipid
profile in children with thalassemia: A prospective
observational study from eastern India. Indian pediatrics 2020
Nov; 57:1072-3 DOI: https://doi.org/10.1007/s13312-020-
-2
Dey A, Sandip C, Arya S. dkk. Correlation of serum lipid
profile with serum iron, TIBC & ferritin levels in beta
thalassemia major patients. Eur J Biol and Med Sci Res 2016;
:17-26
Mashaali JK, Obed FA, Thair NT. Lipid Profile in Iraqi
Children with ß-thalassemia Major. Iraqi J Hematol 2014;
(2):108
Ashar S, Sultan S, Irfan SM, Sheeraz A. Serum fasting lipid
profile in children and adolescents with ß-thalassaemia major
in southern Pakistan. Malay J Pathol 2015; 37(3)
Asif M, Rasheed A. Dyslipidemia in beta thalassemia major
patients. J Saidu Med Col 2015; 5(2):695-7
Inati A, Noureldine MA, Mansour A, Abbas HA. Endocrine
and bone complications in ß-thalassemia intermedia: current
understanding and treatment. BioMed Res Int 2015; 2015
DOI: https://doi.org/10.1155/2015/813098
Tamaddoni A, Nasseri E, Mohammadi E, Qujeq D, Zayeri
F, Zand H, et al. A double-blind randomized controlled trial
of curcumin for improvement in glycemic status, lipid profile
and systemic inflammation in ß-thalassemia major. J Herb
Med 2020;21:100324 DOI: https://doi.org/10.1016
/j.hermed.2019.100324
Setoodeh S, Khorsand M, Takhshid MA. The effects of iron
overload, insulin resistance and oxidative stress on metabolic
disorders in patients with ß-thalassemia major. J Diabetes
Metab Disord 2020; 19:767-74
Boudrahem-Addour N, Izem-Meziane M, Bouguerra K,
Nadjem N, Zidani N, Belhani M, et al. Oxidative status and
plasma lipid profile in ß-thalassemia patients. Hemoglobin
;39(1):36-41 DOI: https://doi.org/10.3109 /03630269.
979997
Casula M, Colpani O, Xie S, Catapano AL, Baragetti A. HDL
in atherosclerotic cardiovascular disease: in search of a role.
Cells 2021; 10(8):1869
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Syeda Sabahat Haidar, Mehvish Sana, Rukhsana Tumrani, Farwa Shafqat
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Journal of Bahria University Medical & Dental College is an open access journal and is licensed under CC BY-NC 4.0. which permits unrestricted non commercial use, distribution and reproduction in any medium, provided the original work is properly cited. To view a copy of this license, visit https://creativecommons.org/licenses/by-nc/4.0 
